2-(Bromomethyl)-1,3-benzothiazole
- CAS No.
- 106086-78-6
- Chemical Name:
- 2-(Bromomethyl)-1,3-benzothiazole
- Synonyms
- 2-BroMoMethyl benzothizaole;2-(BROMOMETHYL)BENZOTHIAZOLE;Benzothiazole,2-(broMoMethyl)-;2-(bromomethyl)benzo[d]thiazole;2-(Bromomethyl)-1,3-benzothiazol;2-(Bromomethyl)-1,3-benzothiazole;2-(bromethyl)benzenebenzothiazole;2-(Bromomethyl)benzothiazole, 98+%;[(Benzo[d]thiazol-2-yl)methyl]bromide;2-(Bromomethyl)-1,3-benzothiazole ,95%
- CBNumber:
- CB2225922
- Molecular Formula:
- C8H6BrNS
- Molecular Weight:
- 228.11
- MDL Number:
- MFCD00461195
- MOL File:
- 106086-78-6.mol
- MSDS File:
- SDS
| Melting point | 47 °C |
|---|---|
| Boiling point | 288℃ |
| Density | 1.680 |
| Flash point | 128℃ |
| storage temp. | Inert atmosphere,2-8°C |
| pka | 0.38±0.10(Predicted) |
| form | crystalline powder |
| color | Pale yellow |
| CAS DataBase Reference | 106086-78-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H302-H315-H318-H335 | |||||||||
| Precautionary statements | P260h-P301+P330+P331-P303+P361+P353-P405-P501a-P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,C,Xn | |||||||||
| Risk Statements | 34-41-37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-36/37/3945-39 | |||||||||
| RIDADR | 3261 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2934208090 | |||||||||
| NFPA 704 |
|
2-(Bromomethyl)-1,3-benzothiazole price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B6226 | 2-(Bromomethyl)-1,3-benzothiazole min. 98.0 % | 106086-78-6 | 1G | $112 | 2026-04-30 | Buy |
| TCI Chemical | B6226 | 2-(Bromomethyl)-1,3-benzothiazole min. 98.0 % | 106086-78-6 | 5G | $445 | 2026-04-30 | Buy |
| Apolloscientific | OR23090 | 2-(Bromomethyl)-1,3-benzothiazole ≥95% | 106086-78-6 | 50mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR23090 | 2-(Bromomethyl)-1,3-benzothiazole ≥95% | 106086-78-6 | 1g | $62 | 2026-06-04 | Buy |
| Apolloscientific | OR23090 | 2-(Bromomethyl)-1,3-benzothiazole ≥95% | 106086-78-6 | 5g | $245 | 2026-06-04 | Buy |
2-(Bromomethyl)-1,3-benzothiazole Chemical Properties, Uses, Production
Synthesis
37859-42-0
106086-78-6
The general procedure for the synthesis of 2-(bromomethyl)benzothiazole using 2-hydroxymethylbenzothiazole as starting material was as follows: 2-hydroxymethylbenzothiazole (1.00 g, 6.05 mmol) was dissolved in an appropriate amount of CH2Cl2 according to Attardo's method 1. Phosphorus tribromide (1.15 mL, 12.1 mmol) was slowly added dropwise to the above solution under argon protection. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent ratio hexane:ethyl acetate = 5:1) to afford 2-(bromomethyl)benzothiazole (786 mg, 57% yield) as a brown solid. The structure of the product was confirmed by the following characterization data: 1H NMR (300 MHz, CDCl3) δ 4.81 (s, 2H), 7.42 (td, 1H, J = 8.1 Hz, 1.1 Hz), 7.50 (td, 1H, J = 8.1 Hz, 1.1 Hz), 7.87 (dd, 1H, J = 8.1 Hz, 1.1 Hz), 8.02 ( dd, 1H, J = 8.1 Hz, 1.1 Hz); 13C NMR (75 MHz, CDCl3) δ 27.1, 121.8, 123.5, 125.9, 126.5, 136.2, 152.8, 166.2; mass spectrometry (EI) showed molecular ion peaks at m/z 227, 229 (M+); and thin-layer chromatography (TLC) showed Rf value of 0.60 (unfolding agent ratio of hexane:ethyl acetate=5:1).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 1, p. 43 - 45
[2] Patent: WO2017/66606, 2017, A1. Location in patent: Page/Page column 95; 96
[3] Journal of the American Chemical Society, 2017, vol. 139, # 21, p. 7318 - 7334
[4] Patent: WO2018/191394, 2018, A1. Location in patent: Page/Page column 135-136
[5] Zhurnal Obshchei Khimii, 1951, vol. 21, p. 2055,2056, 2061; engl. Ausg. S. 2295, 2301
2-(Bromomethyl)-1,3-benzothiazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Zhengzhou GranLen pharmaceutical Technology Co., Ltd. | 0371-85513397 | info@granlen.com | China | 497 | 55 |
View Latest Price from 2-(Bromomethyl)-1,3-benzothiazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | 2-bromomethyl benzothizaole
106086-78-6
|
10g | TargetMol Chemicals Inc. | ||||
 |
2019-07-06 | 5-BROMO-2,1,3-BENZOTHIADIAZOLE
106086-78-6
|
$2.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 2-bromomethyl benzothizaole
106086-78-6
- TargetMol Chemicals Inc.
-
- 5-BROMO-2,1,3-BENZOTHIADIAZOLE
106086-78-6
- $2.00
- 99%
- Career Henan Chemical Co
