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4-Bromo-2-methylpyridine

4-Bromo-2-methylpyridine structure

CAS No.: 22282-99-1

Chemical Name:: 4-Bromo-2-methylpyridine

Synonyms: -4-bromopyridine;4-BROMO-2-PICOLINE;CHEMBRDG-BB 4014101;4-BROMO-2-PICOLINE HCL;4-BROMO-METHYL-PYRIDINE;4-Bromo-2-methylpyridie;4-BROMO-2-METHYLPYRIDINE;2-METHYL-4-BROMOPYRIDINE;4-bormo-2-methylpyridine;4-BroMo-2-Methylpyridine0

CBNumber:: CB9425671

Molecular Formula:: C6H6BrN

Molecular Weight:: 172.02

MDL Number:: MFCD03788196

MOL File:: 22282-99-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:25:48

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4-Bromo-2-methylpyridine Properties

Melting point	26-27°
Boiling point	76 °C / 14mmHg
Density	1.450 g/mL at 25 °C
refractive index	n 20/D 1.556
Flash point	174 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Dichloromethane
form	Pale Yellow Liquid
pka	4.38±0.10(Predicted)
color	Colorless to Light yellow to Light orange
Water Solubility	Miscible with dichloromethane. Immiscible with water.
InChI	InChI=1S/C6H6BrN/c1-5-4-6(7)2-3-8-5/h2-4H,1H3
InChIKey	JFBMFWHEXBLFCR-UHFFFAOYSA-N
SMILES	C1(C)=NC=CC(Br)=C1
CAS DataBase Reference	22282-99-1(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P261-P264-P280-P301+P312-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,Xi

Risk Statements

22-37/38-41-36/37/38-20/21/22

Safety Statements

26-36/39-36

RIDADR

NA 1993 / PGIII

WGK Germany

HazardClass

IRRITANT

HS Code

29333990

Storage Class

10 - Combustible liquids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

NFPA 704

	2
2		0

4-Bromo-2-methylpyridine price More Price(89)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	662739	4-Bromo-2-methylpyridine 96%	22282-99-1	1g	$64.4	2026-04-30	Buy
Sigma-Aldrich	662739	4-Bromo-2-methylpyridine 96%	22282-99-1	250mg	$54.7	2023-06-20	Buy
TCI Chemical	B3279	4-Bromo-2-methylpyridine >98.0%(GC)(T)	22282-99-1	1g	$31	2026-04-30	Buy
TCI Chemical	B3279	4-Bromo-2-methylpyridine >98.0%(GC)(T)	22282-99-1	5g	$92	2026-04-30	Buy
TRC	TRC-B685560-500MG	4-Bromo-2-picoline	22282-99-1	500mg	$84	2026-06-03	Buy

Product number	Packaging	Price	Buy
662739	1g	$64.4	Buy
662739	250mg	$54.7	Buy
B3279	1g	$31	Buy
B3279	5g	$92	Buy
TRC-B685560-500MG	500mg	$84	Buy

4-Bromo-2-methylpyridine Chemical Properties, Uses, Production

Chemical Properties

Light yellow liquid

Uses

4-Bromo-2-methylpyridine is a starting material used in a synthesis of crown-ester-bipyridines and viologens via sodium or nickel reductive coupling, side chain oxidation and esterification.

Uses

Used in the preparation of phenyloxadiazolyl pyridines as immunomodulating agents.

Uses

4-Bromo-2-methylpyridine is used as a starting material in the preparation of crown-ester-bipyridines and viologens through sodium or nickel reductive coupling, side chain oxidation and esterification. Further, it serves as an important raw material and intermediate in organic synthesis, pharmaceuticals, agrochemicals and in dyes.

Synthesis

18437-58-6

22282-99-1

2-Methyl-4-aminopyridine (152) (10.1 g, 93.4 mmol) was used as a raw material, which was dissolved in 48% aqueous hydrobromic acid (165 mL) at -10°C and stirred to form a solution. An aqueous solution of sodium nitrite (7.04 g, 0.102 mol) pre-cooled to 0°C (165 mL) was added dropwise to this solution over a period of 0.5 hours. After the dropwise addition, the reaction mixture was slowly warmed to room temperature and stirring was continued for 16 hours. Upon completion of the reaction, the reaction mixture was diluted with 4 M sodium hydroxide solution (400 mL) and subsequently extracted with tert-butyl methyl ether (TBME). All TBME phases were combined, dried with anhydrous magnesium sulfate and finally concentrated under vacuum to give the target product 4-bromo-2-methylpyridine (153). Yield: 14.8 g (92% yield).LC/MS analysis: retention time 0.57 min, mass spectrum (ES+) m/z 172, 174 ([M+H]+).

References

[1] Patent: WO2008/57497, 2008, A2. Location in patent: Page/Page column 292
[2] Patent: WO2007/89669, 2007, A2. Location in patent: Page/Page column 203-204
[3] Patent: WO2008/57469, 2008, A1. Location in patent: Page/Page column 292
[4] Patent: WO2008/57468, 2008, A1. Location in patent: Page/Page column 292
[5] Patent: WO2004/14913, 2004, A2. Location in patent: Page 81-82

4-Bromo-2-methylpyridine synthesis

Synthesis of 4-Bromo-2-methylpyridine from 4-Amino-2-picoline

4-Bromo-2-methylpyridine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Acetyl bromide Chloroform Phosphorus trichloride Diethyl ether

4-Nitro-2-picoline N-oxide Sodium carbonate 4-Bromopyridine-2-carbaldehyde 2-Picoline-N-oxide 2-Chloro-4-nitropyridine

2-Methyl-4-nitropyridine Methylmagnesium Bromide 2,4-Dibromopyridine

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Preparation Products

(4-Methoxy-pyridin-2-yl)-methanol 4-Methoxypicolinaldehyde 4-Bromo-pyridine-2-carboxylic acid methyl ester tert-Butyl 4-bromopyridin-2-ylcarbamate 2-Methylpyridine-4-boronic acid pinacol ester

4-Bromo-2-pyridinemethanol

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4-Bromo-2-methylpyridine Suppliers

Global Suppliers ( 494)

Supplier	Tel	Email	Country	ProdList	Advantage
JIANGYIN RUISHIPHARM CO.,LIMITED	0510-0510-66227179 18921203887	sales@ruishipharm.com	China	747	58
Jinan Dexinjia Bio&Tech Co., Ltd	0531-82375880 15098789112	3845379039@qq.com	China	1457	58
Jinan Shunyichang new material Co., LTD	18865936198	limin9361@163.com	China	89	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 13582355795	master@sjzsdyn.com	China	2776	65

Supplier	Advantage
JIANGYIN RUISHIPHARM CO.,LIMITED	58
Jinan Dexinjia Bio&Tech Co., Ltd	58
Jinan Shunyichang new material Co., LTD	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65

View Latest Price from 4-Bromo-2-methylpyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	4-Bromo-2-methylpyridine 22282-99-1	$5.00	1KG	98%		Henan Fengda Chemical Co., Ltd
2026-08-20	4-Bromo-2-methylpyridine 22282-99-1	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2026-07-22	4-Bromo-2-methylpyridine 22282-99-1		1kg	99%	100KG	Watson Biotechnology Co.,Ltd

4-Bromo-2-methylpyridine
22282-99-1
$5.00
98%
Henan Fengda Chemical Co., Ltd

4-Bromo-2-methylpyridine
22282-99-1
$1.10
99.00%
Dideu Industries Group Limited

4-Bromo-2-methylpyridine
22282-99-1
99%
Watson Biotechnology Co.,Ltd

4-Bromo-2-methylpyridine Spectrum

4-Bromo-2-methylpyridine(22282-99-1)¹HNMR

22282-99-1 (4-Bromo-2-methylpyridine) Related Search:

1-Hexadecylpyridinium bromide 2,6-Lutidine Azamethiphos 4-Methylpyridine 2-Picoline

2-Bromo-5-nitropyridine 4-Bromopyridine 2,4,6-Collidine 4-Bromo-2,6-dimethylpyridine 2-BROMO-6-METHYLPYRIDINE

3-BROMO-4-METHYLPYRIDINE 4-Bromo-2,6-dimethylaniline 4-Bromo-3-fluorobenzonitrile 4-Bromo-3-fluorobenzaldehyde 4-Bromo-2-chlorobenzonitrile

4-Bromo-3-methylphenol 4-Bromo-3-fluorobenzoic acid 4-Bromo-1-methoxy-2-methylbenzene

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CHEMBRDG-BB 4014101 2-METHYL-4-BROMOPYRIDINE 4-BROMO-2-METHYLPYRIDINE 4-BROMO-2-METHYL-PYRIDINE HYDROCHLORIDE 4-BROMO-2-METHYL-PYRIDINIUM, CHLORIDE 4-BROMO-2-PICOLINE 4-BROMO-2-PICOLINE HCL 4-BROMO-METHYL-PYRIDINE 4-BROMO-2-PICOLINE 4-BROMO-2-METHYLPYRIDINE 4-BROMO-2-METHYLPYRIDINE (4-BROMO-2-PICOLINE) 2-Methyl-4-Bromopyridine HCl 4-BROMO-2-METHYLPYRIDINE 98% 4-bormo-2-methylpyridine 4-Bromo-2-methylpyridie 2-Picoline, 4-bromo- (6CI,8CI) Pyridine, 4-bromo-2-methyl- 4-bromo-2-methylpyridine(SALTDATA: 0.95HBr 0.35H2O) 2 - Methyl - 4 - broMide pyridine 4-BroMo-2-Methylpyridine0 2-Methyl-4-broMopyridine, 97+% 4-Bromo-2-methylpyridine > -4-bromopyridine 4-Bromo-2-methylpyridine ISO 9001：2015 REACH 4-Bromo-2-picoline hydrochloride 4-Bromo-2-methylpyridine, 95% 22282-99-1 22287-99-1 C6H6BrNHCl Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridines Building Blocks C5 to C6 C6 to C7 Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks Bromopyridines Halopyridines pharmacetical Aromatics Boronic Acid Pyridine Series Halides Heterocycles Pyridine Pyridines, Pyrimidines, Purines and Pteredines Heterocyclic Series Pyridines Organohalides Aromatics Compounds