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4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine structure

CAS No.: 23000-43-3

Chemical Name:: 4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

Synonyms: AKOS BBS-00002108;BUTTPARK 75\18-20;4-CHLORO-1-METHYLPYRAZOLO[3,4-D]PYRIMIDINE;4-Chloro-1-methyl-1H-pyrazol[3,4-d]pyrimidine;4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE;1-Methyl-4-chloro-1H-pyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyrimidine, 4-chloro-1-methyl-

CBNumber:: CB2226813

Molecular Formula:: C6H5ClN4

Molecular Weight:: 168.58

MDL Number:: MFCD00661967

MOL File:: 23000-43-3.mol

MSDS File:: SDS

Last updated:2026-05-28 00:13:58

Request For Quotation

4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Properties

Melting point	102-104
Boiling point	294.6±20.0 °C(Predicted)
Density	1.59±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
pka	1.46±0.10(Predicted)
Appearance	White to yellow Solid
InChI	InChI=1S/C6H5ClN4/c1-11-6-4(2-10-11)5(7)8-3-9-6/h2-3H,1H3
InChIKey	AVFLNALVPBLGEV-UHFFFAOYSA-N
SMILES	C1=NC(Cl)=C2C=NN(C)C2=N1
CAS DataBase Reference	23000-43-3
FDA UNII	EAD5BMA4P6

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H332-H335

Precautionary statements

P261-P280-P305+P351+P338

Hazard Note

Harmful

HS Code

2933998090

NFPA 704

	1
2		0

4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR019232	4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine 95%	23000-43-3	250mg	$30	2026-06-04	Buy
Apolloscientific	OR019232	4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine 95%	23000-43-3	500mg	$36	2026-06-04	Buy
Apolloscientific	OR019232	4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine 95%	23000-43-3	1g	$40	2026-06-04	Buy
Matrix Scientific	076239	4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine	23000-43-3	1.00g	$347	2026-05-18	Buy
Matrix Scientific	076239	4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine	23000-43-3	5.00g	$899	2026-05-18	Buy

Product number	Packaging	Price	Buy
OR019232	250mg	$30	Buy
OR019232	500mg	$36	Buy
OR019232	1g	$40	Buy
076239	1.00g	$347	Buy
076239	5.00g	$899	Buy

4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Chemical Properties, Uses, Production

Uses

4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine is a chlorine-substituted organic compound. It is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

5399-92-8

74-88-4

4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

23000-43-3

General procedure for the synthesis of 1-methyl-4-chloropyrazolo[3,4-d]pyrimidines from 4-chloro-1H-pyrazolo[3,4-d]pyrimidines (1.88 g, 0.012 mol) and iodomethane (2.56 g, 0.018 mol): 4-chloro-1H-pyrazolo[3,4-d]pyrimidines and NaH (0.864 g, 0.036 mol) suspension in anhydrous DMF (10 mL) was stirred for 30 min. Subsequently, iodomethane was added and the reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the reaction was quenched with 100 mL of water and extracted with EtOAc (60 mL x 3). The organic layers were combined and concentrated under reduced pressure to afford the target product 1-methyl-4-chloropyrazolo[3,4-d]pyrimidine. Yield: 70.8%; 1H-NMR (400 MHz, DMSO-d6) δ 8.85 (s, 1H), 8.44 (s, 1H), 4.08 (s, 3H).

References

[1] Comptes Rendus Chimie, 2017, vol. 20, # 9-10, p. 927 - 933
[2] Molecules, 2017, vol. 22, # 4,
[3] Patent: CN107383014, 2017, A. Location in patent: Paragraph 0079; 0080; 0081; 0082
[4] European Journal of Medicinal Chemistry, 2018, vol. 155, p. 210 - 228

4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

1-Methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine 4,6-Dichloropyrimidine-5-carbaldehyde Methylhydrazine Iodomethane

N,N-Dimethylformamide Sodium hydride

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Preparation Products

1-Methyl-{N}-propyl-1{H}-pyrazolo[3,4-{d}]pyrimidin-4-amine (9-methyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraen-5-yl)hydrazine

4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Suppliers

Global Suppliers ( 110)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai yuanzuo medical technology co., LTD	021-31775309; 15221510662	yi_shiyan@yuanzuopharm.com	China	139	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Shanghai civi chemical technology co.,Ltd	86-21-34053660	sale@labgogo.com	China	9853	52
Thermo Fisher Scientific	800-810-5118	cnchemical@thermofisher.com	China	17752	75
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58
Nantong Ayeschem Co., Ltd	+86-513-86760116	sales@ayeschem.com	China	99	58
9ding chemical ( Shanghai) Limited	4009209199	sales@9dingchem.com	China	22497	55
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29977	65

Supplier	Advantage
Shanghai yuanzuo medical technology co., LTD	58
J & K SCIENTIFIC LTD.	76
Capot Chemical Co., Ltd	66
Pure Chemistry Scientific Inc.	62
Shanghai civi chemical technology co.,Ltd	52
Thermo Fisher Scientific	75
Shanghai Topbiochem Technology Co., Ltd	58
Nantong Ayeschem Co., Ltd	58
9ding chemical ( Shanghai) Limited	55
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65

View Latest Price from 4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-05-15	4-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine 23000-43-3	$1.00	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd

4-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
23000-43-3
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Spectrum

4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE(23000-43-3)¹HNMR

23000-43-3 (4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine) Related Search:

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BUTTPARK 75\18-20 AKOS BBS-00002108 4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-METHYLPYRAZOLO[3,4-D]PYRIMIDINE 4-Chloro-1-methyl-1H-pyrazol[3,4-d]pyrimidine 1-Methyl-4-chloro-1H-pyrazolo[3,4-d]pyrimidine 1H-Pyrazolo[3,4-d]pyrimidine, 4-chloro-1-methyl- 23000-43-3 Heterocycle-Pyrimidine series