4-CHLORO-3-METHOXYBENZOIC ACID
- CAS No.
- 85740-98-3
- Chemical Name:
- 4-CHLORO-3-METHOXYBENZOIC ACID
- Synonyms
- TIMTEC-BB SBB008504;4-Chloro-m-anisic Acid;4-Chloro-3-Methoxybenzoic;3-methoxy-4-chlorobenzoic acid;4-CHLORO-3-METHOXYBENZOIC ACID;Benzoic acid,4-chloro-3-methoxy-;4-Chloro-3-methoxybenzoic acid, >=98%;4-CHLORO-3-METHOXYBENZOIC ACID ---POWDER---
- CBNumber:
- CB2240372
- Molecular Formula:
- C8H7ClO3
- Molecular Weight:
- 186.59
- MDL Number:
- MFCD00269640
- MOL File:
- 85740-98-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Chloro-3-methoxybenzoic acid AldrichCPR | ANV00031 | 1G | $172 |
| 4-Chloro-3-methoxybenzoic Acid >98.0%(GC)(T) | C3304 | 1g | $39 |
| 4-Chloro-3-methoxybenzoic Acid >98.0%(GC)(T) | C3304 | 5g | $112 |
| 4-Chloro-3-methoxybenzoic acid | FC55332 | 50g | $125 |
| 4-Chloro-3-methoxybenzoic acid | 2621-5-0A | 5G | $141 |
| More product size | |||
| Melting point | 217.0 to 221.0 °C |
|---|---|
| Boiling point | 325.4±22.0 °C(Predicted) |
| Density | 1.352±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.85±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| CAS DataBase Reference | 85740-98-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06, GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H400 | |||||||||
| Precautionary statements | P273-P301+P310 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 36/37/38-50-25 | |||||||||
| Safety Statements | 26-36/37/39-61-45 | |||||||||
| RIDADR | 3077 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2918999090 | |||||||||
| NFPA 704 |
|
4-CHLORO-3-METHOXYBENZOIC ACID price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ANV00031 | 4-Chloro-3-methoxybenzoic acid AldrichCPR | 85740-98-3 | 1G | $172 | 2023-01-07 | Buy |
| TCI Chemical | C3304 | 4-Chloro-3-methoxybenzoic Acid >98.0%(GC)(T) | 85740-98-3 | 1g | $39 | 2025-07-31 | Buy |
| TCI Chemical | C3304 | 4-Chloro-3-methoxybenzoic Acid >98.0%(GC)(T) | 85740-98-3 | 5g | $112 | 2025-07-31 | Buy |
| Biosynth Carbosynth | FC55332 | 4-Chloro-3-methoxybenzoic acid | 85740-98-3 | 50g | $125 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2621-5-0A | 4-Chloro-3-methoxybenzoic acid | 85740-98-3 | 5G | $141 | 2021-12-16 | Buy |
4-CHLORO-3-METHOXYBENZOIC ACID Chemical Properties,Uses,Production
Uses
4-Chloro-3-methoxybenzoic acid can be used to synthesize specific drug molecules, such as a key intermediate for the antiarrhythmic drug amiodarone.
Synthesis
73909-16-7
85740-98-3
B. Synthesis of 4-chloro-3-methoxybenzoic acid (0200) To crude 1-chloro-2-methoxy-4-methylbenzene (7.8 g, 50 mmol) was added an aqueous solution of potassium permanganate (KMnO4, 19.8 g, 125 mmol) (300 mL). The reaction mixture was stirred vigorously under reflux conditions for 17 h. After completion of the reaction, the filter was passed through diatomaceous earth and the filter cake was washed with hot water (200 mL). The clarified filtrate was washed with ether (2 x 150 mL) and then acidified with concentrated hydrochloric acid (HCl) to pH < 2. After addition of concentrated hydrochloric acid (9 mL), the precipitate was collected by filtration to give pure white solid 4-chloro-3-methoxybenzoic acid (5.36 g, 58% yield). Electrospray mass spectrometry (ES-MS) showed (M + H)+ peak located at m/z = 187.
References
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 23, p. 4408 - 4414
[2] European Journal of Medicinal Chemistry, 2011, vol. 46, # 12, p. 5754 - 5762
[3] Archiv der Pharmazie, 2011, vol. 344, # 11, p. 745 - 754
[4] Chemical Biology and Drug Design, 2013, vol. 82, # 3, p. 336 - 347
[5] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 315 - 322
4-CHLORO-3-METHOXYBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9983 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14343 | 58 |
View Lastest Price from 4-CHLORO-3-METHOXYBENZOIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-09 | 4-CHLORO-3-METHOXYBENZOIC ACID
85740-98-3
|
US $6.68 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- 4-CHLORO-3-METHOXYBENZOIC ACID
85740-98-3
- US $6.68 / KG
- 97%-99%
- Career Henan Chemical Co
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