4-Chloro-3-methoxybenzoic acid
- CAS No.
- 85740-98-3
- Chemical Name:
- 4-Chloro-3-methoxybenzoic acid
- Synonyms
- TIMTEC-BB SBB008504;4-Chloro-m-anisic Acid;4-Chloro-3-Methoxybenzoic;4-Chloro-3-methoxybenzoic acid;3-methoxy-4-chlorobenzoic acid;Benzoic acid,4-chloro-3-methoxy-;4-Chloro-3-methoxybenzoic acid, >=98%;4-CHLORO-3-METHOXYBENZOIC ACID ---POWDER---
- CBNumber:
- CB2240372
- Molecular Formula:
- C8H7ClO3
- Molecular Weight:
- 186.59
- MDL Number:
- MFCD00269640
- MOL File:
- 85740-98-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 217.0 to 221.0 °C |
|---|---|
| Boiling point | 325.4±22.0 °C(Predicted) |
| Density | 1.352±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 3.85±0.10(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 85740-98-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06, GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H400 | |||||||||
| Precautionary statements | P273-P301+P310 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 36/37/38-50-25 | |||||||||
| Safety Statements | 26-36/37/39-61-45 | |||||||||
| RIDADR | 3077 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2918999090 | |||||||||
| NFPA 704 |
|
4-Chloro-3-methoxybenzoic acid price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ANV00031 | 4-Chloro-3-methoxybenzoic acid AldrichCPR | 85740-98-3 | 1G | $172 | 2023-01-07 | Buy |
| TCI Chemical | C3304 | 4-Chloro-3-methoxybenzoic Acid >98.0%(GC)(T) | 85740-98-3 | 1g | $31 | 2026-04-30 | Buy |
| TCI Chemical | C3304 | 4-Chloro-3-methoxybenzoic Acid >98.0%(GC)(T) | 85740-98-3 | 5g | $90 | 2026-04-30 | Buy |
| Usbiological | 270288 | 4-Chloro-3-methoxybenzoic acid Asreported | 85740-98-3 | 1g | $349 | 2026-06-03 | Buy |
| Usbiological | 270288 | 4-Chloro-3-methoxybenzoic acid Asreported | 85740-98-3 | 2g | $482 | 2026-06-03 | Buy |
4-Chloro-3-methoxybenzoic acid Chemical Properties,Uses,Production
Uses
4-Chloro-3-methoxybenzoic acid can be used to synthesize specific drug molecules, such as a key intermediate for the antiarrhythmic drug amiodarone.
Synthesis
73909-16-7
85740-98-3
B. Synthesis of 4-chloro-3-methoxybenzoic acid (0200) To crude 1-chloro-2-methoxy-4-methylbenzene (7.8 g, 50 mmol) was added an aqueous solution of potassium permanganate (KMnO4, 19.8 g, 125 mmol) (300 mL). The reaction mixture was stirred vigorously under reflux conditions for 17 h. After completion of the reaction, the filter was passed through diatomaceous earth and the filter cake was washed with hot water (200 mL). The clarified filtrate was washed with ether (2 x 150 mL) and then acidified with concentrated hydrochloric acid (HCl) to pH < 2. After addition of concentrated hydrochloric acid (9 mL), the precipitate was collected by filtration to give pure white solid 4-chloro-3-methoxybenzoic acid (5.36 g, 58% yield). Electrospray mass spectrometry (ES-MS) showed (M + H)+ peak located at m/z = 187.
References
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 23, p. 4408 - 4414
[2] European Journal of Medicinal Chemistry, 2011, vol. 46, # 12, p. 5754 - 5762
[3] Archiv der Pharmazie, 2011, vol. 344, # 11, p. 745 - 754
[4] Chemical Biology and Drug Design, 2013, vol. 82, # 3, p. 336 - 347
[5] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 315 - 322
4-Chloro-3-methoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Wuhan Haizheng Industry & Trade Development Co. Ltd | 027-8866 0053/88660577/88660578 | China | 1070 | 55 | |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3993 | 55 |
View Lastest Price from 4-Chloro-3-methoxybenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 4-CHLORO-3-METHOXYBENZOIC ACID
85740-98-3
|
$6.68 | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- 4-CHLORO-3-METHOXYBENZOIC ACID
85740-98-3
- $6.68
- 97%-99%
- Career Henan Chemical Co
85740-98-3(4-Chloro-3-methoxybenzoic acid)Related Search:
1of4
