2-Chloro-4-methoxybenzoic acid
- CAS No.
- 21971-21-1
- Chemical Name:
- 2-Chloro-4-methoxybenzoic acid
- Synonyms
- MIF-IN-2 Impurity 3;Dotinurad Impurity 162;2-Chloro-p-anisic Acid;2-Chloro-4-metxybenzoic acid;2-Chloro-4-methoxybenzoic acid;2-Chloro-4-methoxybenzoicacid,98%;Benzoic acid, 2-chloro-4-methoxy-;2-CHLORO-4-(METHYLOXY)BENZOIC ACID;2-Chloro-4-methoxybenzoic Acid >2-Chloro-4-Methoxybenzoic acid, 97%+
- CBNumber:
- CB0947022
- Molecular Formula:
- C8H7ClO3
- Molecular Weight:
- 186.59
- MDL Number:
- MFCD00085943
- MOL File:
- 21971-21-1.mol
| Product description | Number | Pack Size | Price |
| 2-Chloro-4-methoxybenzoic Acid >98.0%(GC)(T) | C3077 | 1g | $33 |
| 2-Chloro-4-methoxybenzoic Acid >98.0%(GC)(T) | C3077 | 5g | $106 |
| 2-Chloro-4-methoxybenzoic Acid | C367880 | 2.5g | $140 |
| 2-CHLORO-4-METHOXYBENZOIC ACID 95.00% | HCH0027735 | 1G | $852.55 |
| 2-CHLORO-4-METHOXYBENZOIC ACID 95.00% | HCH0027735 | 2.5G | $1227.82 |
| More product size | |||
| Melting point | 210.0 to 214.0 °C |
|---|---|
| Boiling point | 303.0±22.0 °C(Predicted) |
| Density | 1.352±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated) |
| pka | 3.32±0.25(Predicted) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 21971-21-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
2-Chloro-4-methoxybenzoic acid price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3077 | 2-Chloro-4-methoxybenzoic Acid >98.0%(GC)(T) | 21971-21-1 | 1g | $33 | 2025-07-31 | Buy |
| TCI Chemical | C3077 | 2-Chloro-4-methoxybenzoic Acid >98.0%(GC)(T) | 21971-21-1 | 5g | $106 | 2025-07-31 | Buy |
| TRC | C367880 | 2-Chloro-4-methoxybenzoic Acid | 21971-21-1 | 2.5g | $140 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0027735 | 2-CHLORO-4-METHOXYBENZOIC ACID 95.00% | 21971-21-1 | 1G | $852.55 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0027735 | 2-CHLORO-4-METHOXYBENZOIC ACID 95.00% | 21971-21-1 | 2.5G | $1227.82 | 2021-12-16 | Buy |
2-Chloro-4-methoxybenzoic acid Chemical Properties,Uses,Production
Chemical Properties
White to pale yellow powder
Uses
2-Chloro-4-Methoxybenzoic Acid has been used as a reactant for the preparation of benzamidochromenone carboxylic acids as selective agonists for orphan G protein-coupled receptor GPR35
Synthesis
104253-45-4
21971-21-1
2-Chloro-4-methoxybenzoic acid was synthesized as follows: methyl 2-chloro-4-methoxybenzoate (1.1 g) was dissolved in a mixed solvent of THF/MeOH/water (12 mL/3 mL/3 mL) at room temperature. Subsequently, LiOH (461 mg) dissolved in water was added. After the reaction was carried out for 2 h, the pH of the reaction mixture was adjusted to 4 with 1 N HCl. Next, the reaction mixture was partitioned between ethyl acetate and water. The organic layer was separated, washed with brine and dried over MgSO4. Finally, the resulting solid was ground in ether to give 1.0 g (98% yield) of 2-chloro-4-methoxybenzoic acid. Mass spectrometry (MS) analysis showed 187 (MH+) and high performance liquid chromatography (HPLC) retention time (tR): 2.04 min.
References
[1] Patent: US2004/102435, 2004, A1
2-Chloro-4-methoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8753 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29833 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
View Lastest Price from 2-Chloro-4-methoxybenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-30 | 2-Chloro-4-methoxybenzoic acid
21971-21-1
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-10-13 | 2-Chloro-4-methoxybenzoic acid
21971-21-1
|
US $2.20-8.80 / kg | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2019-07-10 | 2-Chloro-4-methoxybenzoic acid
21971-21-1
|
US $3.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 2-Chloro-4-methoxybenzoic acid
21971-21-1
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Chloro-4-methoxybenzoic acid
21971-21-1
- US $2.20-8.80 / kg
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2-Chloro-4-methoxybenzoic acid
21971-21-1
- US $3.00 / KG
- 99%
- Career Henan Chemical Co
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