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2-Chloro-4-methoxybenzoic acid

2-Chloro-4-methoxybenzoic acid Structure
2-Chloro-4-methoxybenzoic acid structure
CAS No.
21971-21-1
Chemical Name:
2-Chloro-4-methoxybenzoic acid
Synonyms
MIF-IN-2 Impurity 3;Dotinurad Impurity 162;2-Chloro-p-anisic Acid;2-Chloro-4-metxybenzoic acid;2-Chloro-4-methoxybenzoic acid;2-Chloro-4-methoxybenzoicacid,98%;Benzoic acid, 2-chloro-4-methoxy-;2-CHLORO-4-(METHYLOXY)BENZOIC ACID;2-Chloro-4-methoxybenzoic Acid >2-Chloro-4-Methoxybenzoic acid, 97%+
CBNumber:
CB0947022
Molecular Formula:
C8H7ClO3
Molecular Weight:
186.59
MDL Number:
MFCD00085943
MOL File:
21971-21-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:58:57
Product description Number Pack Size Price
2-Chloro-4-methoxybenzoic Acid >98.0%(GC)(T) C3077 1g $35
2-Chloro-4-methoxybenzoic Acid >98.0%(GC)(T) C3077 5g $113
2-Chloro-4-methoxybenzoic acid Asreported 270271 1g $349
2-Chloro-4-methoxybenzoic acid Asreported 270271 2g $482
2-Chloro-4-methoxybenzoic acid Asreported 270271 5g $704
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2-Chloro-4-methoxybenzoic acid Properties

Melting point 210.0 to 214.0 °C
Boiling point 303.0±22.0 °C(Predicted)
Density 1.352±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated)
form Solid
pka 3.32±0.25(Predicted)
color White to Off-White
CAS DataBase Reference 21971-21-1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
HS Code  2916399090
NFPA 704
0
2 0

2-Chloro-4-methoxybenzoic acid price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C3077 2-Chloro-4-methoxybenzoic Acid >98.0%(GC)(T) 21971-21-1 1g $35 2026-04-30 Buy
TCI Chemical C3077 2-Chloro-4-methoxybenzoic Acid >98.0%(GC)(T) 21971-21-1 5g $113 2026-04-30 Buy
Usbiological 270271 2-Chloro-4-methoxybenzoic acid Asreported 21971-21-1 1g $349 2026-06-03 Buy
Usbiological 270271 2-Chloro-4-methoxybenzoic acid Asreported 21971-21-1 2g $482 2026-06-03 Buy
Usbiological 270271 2-Chloro-4-methoxybenzoic acid Asreported 21971-21-1 5g $704 2026-06-03 Buy
Product number Packaging Price Buy
C3077 1g $35 Buy
C3077 5g $113 Buy
270271 1g $349 Buy
270271 2g $482 Buy
270271 5g $704 Buy

2-Chloro-4-methoxybenzoic acid Chemical Properties,Uses,Production

Chemical Properties

White to pale yellow powder

Uses

2-Chloro-4-Methoxybenzoic Acid has been used as a reactant for the preparation of benzamidochromenone carboxylic acids as selective agonists for orphan G protein-coupled receptor GPR35

Synthesis

METHYL 2-CHLORO-4-METHOXYBENZOATE

104253-45-4

2-Chloro-4-methoxybenzoic acid

21971-21-1

2-Chloro-4-methoxybenzoic acid was synthesized as follows: methyl 2-chloro-4-methoxybenzoate (1.1 g) was dissolved in a mixed solvent of THF/MeOH/water (12 mL/3 mL/3 mL) at room temperature. Subsequently, LiOH (461 mg) dissolved in water was added. After the reaction was carried out for 2 h, the pH of the reaction mixture was adjusted to 4 with 1 N HCl. Next, the reaction mixture was partitioned between ethyl acetate and water. The organic layer was separated, washed with brine and dried over MgSO4. Finally, the resulting solid was ground in ether to give 1.0 g (98% yield) of 2-chloro-4-methoxybenzoic acid. Mass spectrometry (MS) analysis showed 187 (MH+) and high performance liquid chromatography (HPLC) retention time (tR): 2.04 min.

References

[1] Patent: US2004/102435, 2004, A1

2-Chloro-4-methoxybenzoic acid Preparation Products And Raw materials

Raw materials

METHYL 2-CHLORO-4-METHOXYBENZOATE Methanol Tetrahydrofuran Water

Preparation Products

METHYL 2-CHLORO-4-METHOXYBENZOATE

2-Chloro-4-methoxybenzoic acid Suppliers

Global( 165)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15350571055 Sibel@chuanghaibio.com China 8737 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-15225627621 +86-13213167925 jiuyitime@fdachem.com China 16505 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3004 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2971 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63645 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10817 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
career henan chemical co 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58

View Lastest Price from 2-Chloro-4-methoxybenzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-4-methoxybenzoic acid pictures 2026-07-02 2-Chloro-4-methoxybenzoic acid
21971-21-1
 $2.20-8.80 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2-Chloro-4-methoxybenzoic acid pictures 2026-03-20 2-Chloro-4-methoxybenzoic acid
21971-21-1
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Chloro-4-methoxybenzoic acid pictures 2019-07-10 2-Chloro-4-methoxybenzoic acid
21971-21-1
 $3.00 1KG 99% 100kg Career Henan Chemical Co

2-Chloro-4-methoxybenzoic acid Spectrum

2-Chloro-4-methoxybenzoic acid(21971-21-1)1HNMR

21971-21-1(2-Chloro-4-methoxybenzoic acid)Related Search:

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2-CHLORO-4-(METHYLOXY)BENZOIC ACID 2-Chloro-4-metxybenzoic acid 2-Chloro-4-methoxybenzoic acid 2-Chloro-4-Methoxybenzoic acid, 97%+ 2-Chloro-4-methoxybenzoic Acid > Benzoic acid, 2-chloro-4-methoxy- 2-Chloro-4-methoxybenzoicacid,98% 2-Chloro-p-anisic Acid Dotinurad Impurity 162 MIF-IN-2 Impurity 3 21971-21-1 Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts