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ChemicalBook >> CAS DataBase List >>(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone

(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone

(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Structure
(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone structure
CAS No.
73903-17-0
Chemical Name:
(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Synonyms
JNJ 10191584;6-chloro-2-(4-methylpiperazine-1-carbonyl)-1H-1,3-benzodiazole;PIPERAZINE, 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYL-;Methanone, (6-chloro-1H-benzimidazol-2-yl)(4-methyl-1-piperazinyl)-;(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone;(5-Chloro-1H-benzo[d]imidazol-2-yl)(4-methylpiperazin-1-yl)methanone
CBNumber:
CB22454098
Molecular Formula:
C13H15ClN4O
Molecular Weight:
278.74
MDL Number:
MFCD10565946
MOL File:
73903-17-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:50:34
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(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Properties

form Solid
color White to off-white
FDA UNII 7EE5T3WL8P

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth YCA90317 JNJ 10191584 73903-17-0 100mg $985 2026-06-05 Buy
Biosynth YCA90317 JNJ 10191584 73903-17-0 250mg $1607.5 2026-06-05 Buy
ChemScene CS-0082926 JNJ10191584 99.95% 73903-17-0 5mg $100 2026-06-04 Buy
ChemScene CS-0082926 JNJ10191584 99.95% 73903-17-0 10mg $166 2026-06-04 Buy
ChemScene CS-0082926 JNJ10191584 99.95% 73903-17-0 25mg $333 2026-06-04 Buy
Product number Packaging Price Buy
YCA90317 100mg $985 Buy
YCA90317 250mg $1607.5 Buy
CS-0082926 5mg $100 Buy
CS-0082926 10mg $166 Buy
CS-0082926 25mg $333 Buy

(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Chemical Properties,Uses,Production

Uses

JNJ10191584 (VUF6002) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM. JNJ10191584 shows 540-fold selectivity to H4 receptor over H3 receptor with a Ki value of 14.1 μM. JNJ10191584 inhibits chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively[1][2].

Definition

ChEBI: (6-chloro-1H-benzimidazol-2-yl)-(4-methyl-1-piperazinyl)methanone is a member of benzimidazoles.

in vivo

JNJ10191584 (10 μg/μL; intra locus coeruleus (LC) administration; once) abolishs VUF-induced anti-allodynic effect in spared nerve injury (SNI) mice[1]. JNJ10191584 (10 μg/μL; intra LC administration; once) prevents the anti-allodynic effect of VUF 8430 in SNI mice[1]. JNJ10191584 (6 μg/mouse; intrathecal administration; pretreat once) prevents VUF 8430-induced anti-allodynic effect in SNI mice[1].

IC 50

Human H4 Receptor: 26 nM (Ki); human H3 receptor: 14.1 μM (Ki)

References

[1] Venable JD, et al. Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. J Med Chem. 2005 Dec 29;48(26):8289-98. DOI:10.1021/jm0502081
[2] Sanna MD, et al. Histamine H4 receptor stimulation in the locus coeruleus attenuates neuropathic pain by promoting the coeruleospinal noradrenergic inhibitory pathway. Eur J Pharmacol. 2020 Feb 5;868:172859. DOI:10.1016/j.ejphar.2019.172859

(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Preparation Products And Raw materials

Raw materials

Preparation Products

(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4860 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977 wj520wjxby@126.com China 1940 55
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 sales@sarms4muscle.com China 10378 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 5000 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Supplier Advantage
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Chuzhou KeMail Chemical Technology Co., Ltd 55
BOC Sciences 58
Zhejiang J&C Biological Technology Co.,Limited 58
TargetMol Chemicals Inc. 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

View Lastest Price from (6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JNJ-10191584 pictures 2026-07-15 JNJ-10191584
73903-17-0
 $1520.00-2500.00 10g TargetMol Chemicals Inc.
  • JNJ-10191584 pictures
  • JNJ-10191584
    73903-17-0
  • $1520.00-2500.00
  • TargetMol Chemicals Inc.

73903-17-0((6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone)Related Search:

1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate 1H-Benzimidazole-2-carboxaldehyde, 5-chloro- (6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone 1H-Benzimidazole-2-carboxamide,N-ethyl-(9CI) 1H-Benzimidazole-2-carboxamide,N,N-dimethyl-(9CI)
Mecamylamine hydrochloride

1of2

JNJ 10191584 PIPERAZINE, 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYL- Methanone, (6-chloro-1H-benzimidazol-2-yl)(4-methyl-1-piperazinyl)- 6-chloro-2-(4-methylpiperazine-1-carbonyl)-1H-1,3-benzodiazole (5-Chloro-1H-benzo[d]imidazol-2-yl)(4-methylpiperazin-1-yl)methanone (6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone 73903-17-0