(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone

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(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone manufacturers

  • JNJ-10191584
  • JNJ-10191584 pictures
  • $1980.00
  • 2026-07-15
  • CAS:73903-17-0
  • Purity:
  • Supply Ability: 10g
(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Basic information
Product Name:(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
Synonyms:JNJ 10191584;PIPERAZINE, 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYL-;Methanone, (6-chloro-1H-benzimidazol-2-yl)(4-methyl-1-piperazinyl)-;6-chloro-2-(4-methylpiperazine-1-carbonyl)-1H-1,3-benzodiazole;(5-Chloro-1H-benzo[d]imidazol-2-yl)(4-methylpiperazin-1-yl)methanone;(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
CAS:73903-17-0
MF:C13H15ClN4O
MW:278.74
EINECS:
Product Categories:
Mol File:73903-17-0.mol
(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Structure
(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Chemical Properties
form Solid
color White to off-white
Safety Information
MSDS Information
(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Usage And Synthesis
UsesJNJ10191584 (VUF6002) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM. JNJ10191584 shows 540-fold selectivity to H4 receptor over H3 receptor with a Ki value of 14.1 μM. JNJ10191584 inhibits chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively[1][2].
DefinitionChEBI: (6-chloro-1H-benzimidazol-2-yl)-(4-methyl-1-piperazinyl)methanone is a member of benzimidazoles.
in vivo

JNJ10191584 (10 μg/μL; intra locus coeruleus (LC) administration; once) abolishs VUF-induced anti-allodynic effect in spared nerve injury (SNI) mice[1]. JNJ10191584 (10 μg/μL; intra LC administration; once) prevents the anti-allodynic effect of VUF 8430 in SNI mice[1]. JNJ10191584 (6 μg/mouse; intrathecal administration; pretreat once) prevents VUF 8430-induced anti-allodynic effect in SNI mice[1].

IC 50Human H4 Receptor: 26 nM (Ki); human H3 receptor: 14.1 μM (Ki)
References[1] Venable JD, et al. Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. J Med Chem. 2005 Dec 29;48(26):8289-98. DOI:10.1021/jm0502081
[2] Sanna MD, et al. Histamine H4 receptor stimulation in the locus coeruleus attenuates neuropathic pain by promoting the coeruleospinal noradrenergic inhibitory pathway. Eur J Pharmacol. 2020 Feb 5;868:172859. DOI:10.1016/j.ejphar.2019.172859
(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone Preparation Products And Raw materials
Tag:(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone(73903-17-0) Related Product Information
(6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone 1H-BENZIMIDAZOLE-2-CARBOXALDEHYDE, 5-CHLORO- 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE 1H-Benzimidazole-2-carboxamide,N-ethyl-(9CI) 1H-Benzimidazole-2-carboxamide,N,N-dimethyl-(9CI) Mecamylamine hydrochloride