Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile

4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile

4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile Structure
4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile structure
CAS No.
675126-26-8
Chemical Name:
4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile
Synonyms
Gefitinib PI-1;Gefitinib Impurity 44;-nitro-4-methoxy-5-(3-morpholinopropoxy)benzonitrile;5-(2-morpholinoethoxy)-4-methoxy-2-nitrobenzonitrile;4-Methoxy-2-nitro-5-(3-Morpholinopropoxy)benzonitrile;2-Nitro-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile;4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile;3-methoxy-4-(3-morpholinopropoxy)-2-nitrobenzonitrile;4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile;4-Methoxy-5-(3-morpholin-4-yl-propoxy)-2-nitro-benzonitriLE
CBNumber:
CB22469920
Molecular Formula:
C15H19N3O5
Molecular Weight:
321.33
MDL Number:
MFCD11110477
MOL File:
675126-26-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-06 09:30:50
Request For Quotation

4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile Properties

Melting point 127℃
Boiling point 522.3±50.0 °C(Predicted)
Density 1.29
storage temp. Sealed in dry,Room Temperature
pka 6.96±0.10(Predicted)
form Solid
color Light yellow to yellow
InChI InChI=1S/C15H19N3O5/c1-21-14-10-13(18(19)20)12(11-16)9-15(14)23-6-2-3-17-4-7-22-8-5-17/h9-10H,2-8H2,1H3
InChIKey FYCDMKYKGPHRFW-UHFFFAOYSA-N
SMILES C(#N)C1=CC(OCCCN2CCOCC2)=C(OC)C=C1[N+]([O-])=O

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2934999090

4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0131908 Gefitinib impurity 1 99.59% 675126-26-8 500mg $27 2026-06-04 Buy
Apolloscientific OR345594 4-Methoxy-5-(3-morpholin-4-yl-propoxy)-2-nitro-benzonitrile >98% 675126-26-8 1g $21 2026-06-04 Buy
Apolloscientific OR345594 4-Methoxy-5-(3-morpholin-4-yl-propoxy)-2-nitro-benzonitrile >98% 675126-26-8 5g $25 2026-06-04 Buy
Apolloscientific OR345594 4-Methoxy-5-(3-morpholin-4-yl-propoxy)-2-nitro-benzonitrile >98% 675126-26-8 25g $73 2026-06-04 Buy
Apolloscientific OR345594 4-Methoxy-5-(3-morpholin-4-yl-propoxy)-2-nitro-benzonitrile >98% 675126-26-8 100g $233 2026-06-04 Buy
Product number Packaging Price Buy
CS-0131908 500mg $27 Buy
OR345594 1g $21 Buy
OR345594 5g $25 Buy
OR345594 25g $73 Buy
OR345594 100g $233 Buy

4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile Chemical Properties, Uses, Production

Uses

4-Methoxy-5-[3-(morpholin-4-yl)propoxy]-2-nitrobenzonitrile is a useful research chemical compound used in the preparation of carbon-11 iressa as PET cancer imaging agent for epidermal growth factor receptor tyrosine kinase.

General Description

4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile is a gefitinib intermediate.

Synthesis

3-(3-morpholinylpropoxy)-4-methoxybenzonitrile

675126-28-0

2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile

675126-26-8

General procedure for the synthesis of 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile from 4-methoxy-3-(3-morpholinopropoxy)benzonitrile: In a 250 mL single-necked flask, 13.0 g (47.0 mmol) of 4-methoxy-3-(3-morpholinopropoxy)benzonitrile and 17 mL of concentrated nitric acid (65%, 376 mmol) were added followed by 17 mL of glacial acetic acid was added. The mixture was stirred at room temperature for about 2 hours until a large amount of solid precipitated, and stirring was continued for 1 hour. Upon completion of the reaction, 52 g of ice water was added to the reaction mixture and stirring was continued for 30 minutes. The solid product was collected by diafiltration and the filter cake was washed with ice water to a pH of about 7. After drying, 14.4 g of white solid product was obtained in 95.3% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 15, p. 4102 - 4106
[2] Patent: CN107586279, 2018, A. Location in patent: Paragraph 0008; 0017
[3] Patent: CN105503749, 2016, A. Location in patent: Paragraph 0051; 0052
[4] Molecules, 2017, vol. 22, # 10,
[5] Heterocycles, 2007, vol. 71, # 1, p. 39 - 48

4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile Preparation Products And Raw materials

Raw materials

3-(3-morpholinylpropoxy)-4-methoxybenzonitrile

Preparation Products

4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile Suppliers

Global Suppliers ( 159)
Supplier Tel Email Country ProdList Advantage
Biocompounds Pharmaceutical Inc. 21-57687675 yanjie@biocompounds.com China 74 62
Hebei Mingji Chemical Technology Co., Ltd 13731109507 1581841507@qq.com China 491 58
Shanghai Yuzhicheng Pharmaceutical Technology Co., Ltd. 13361818591 2415195517@qq.com China 45 58
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai XueEr Pharmaceutical Technology Co., Ltd 021-34622192 13917187091 1021708276@qq.com China 81 57
BioBioPha Co., Ltd. 0871-65217109 y.liu@mail.biobiopha.com China 5641 65
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9510 58
SynAsst Chemical. 021-60343070 China 12731 55
Supplier Advantage
Biocompounds Pharmaceutical Inc. 62
Hebei Mingji Chemical Technology Co., Ltd 58
Shanghai Yuzhicheng Pharmaceutical Technology Co., Ltd. 58
Energy Chemical 61
Adamas Reagent, Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai XueEr Pharmaceutical Technology Co., Ltd 57
BioBioPha Co., Ltd. 65
Shanghai Topbiochem Technology Co., Ltd 58
SynAsst Chemical. 55

View Latest Price from 4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile pictures 2026-08-03 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile
675126-26-8
 1kg 0.98 1000 Henan Boweixin Biotechnology Co., Ltd.
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile pictures 2025-12-24 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
675126-26-8
 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
2-Nitro-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile pictures 2020-02-26 2-Nitro-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile
675126-26-8
 100g 99%+ 200 tons Shaanxi Dideu Medichem Co. Ltd

675126-26-8 (4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile) Related Search:

4,4'-(propane-1,3-diyl)bismorpholine 4-Defluoro-4-hydroxy Gefitinib 4-Methoxy-5-(3-Morpholinopropoxy)-2-nitrobenzaMide Gefitinib-d6 4-methoxy-3-(3-morpholinopropoxy)-2-nitrobenzonitrile
Gefitinib N-Oxide Gefitinib Impurity 35 N-(3-chloro-4-fluorophenyl)-7 -methoxy-6-(3-morpholinopropoxy)-N-(3-morpholinopropyl)quinazolin-4-amine Gefitinib 3,4-Difluoro Impurity HCl 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one
Gefitinib Impurity 8 Gefitinib Chloro Impurity Gefitinib Impurity 11 Gefitinib 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one
O-Desmorpholinopropyl Gefitinib 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate

1of4

4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile 2-Nitro-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile 4-Methoxy-2-nitro-5-(3-Morpholinopropoxy)benzonitrile 4-METHOXY-5-(3-MORPHOLINOPROPOXY) -2-NITROBENZONITRILE _675126-26-8 Gefitinib PI-1 4-Methoxy-5-(3-Morpholinopropoxy)-2-Nitrobenzonitrile Gefitinib HCL InterMediates G4 Benzonitrile,4-Methoxy-5-[3-(4-Morpholinyl)propoxy]-2-nitro- -nitro-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 4-Methoxy-5-(3-morpholin-4-yl-propoxy)-2-nitro-benzonitriLE 5-(2-morpholinoethoxy)-4-methoxy-2-nitrobenzonitrile Gefitinib Impurity 44 4-methoxy-5-[3-(morpholin-4-yl)propoxy]-2- nitro benzonitrile (GFT-III) 3-methoxy-4-(3-morpholinopropoxy)-2-nitrobenzonitrile 4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile 675126-26-8