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2-Chloro-5-iodothiophene

2-Chloro-5-iodothiophene Structure
2-Chloro-5-iodothiophene structure
CAS No.
28712-49-4
Chemical Name:
2-Chloro-5-iodothiophene
Synonyms
2-Chloro-5-iodothiophene;Thiophene, 2-chloro-5-iodo-
CBNumber:
CB22487528
Molecular Formula:
C4H2ClIS
Molecular Weight:
244.48
MDL Number:
MFCD18382465
MOL File:
28712-49-4.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:46
Product description Number Pack Size Price
2-Chloro-5-iodothiophene 096648 250.00mg $545
2-Chloro-5-iodothiophene 096648 1.00g $1210
2-CHLORO-5-IODOTHIOPHENE 95.00% HCH0363552 5MG $496.11
2-Chloro-5-iodothiophene 95+% 096648 250mg $545
2-Chloro-5-iodothiophene 95+% 096648 1g $1210
Request For Quotation

2-Chloro-5-iodothiophene Properties

Melting point -25--24 °C
Boiling point 95-96 °C(Press: 14 Torr)
Density 2.164±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H312-H315-H335-H332-H302
Precautionary statements  P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P

2-Chloro-5-iodothiophene price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 096648 2-Chloro-5-iodothiophene 28712-49-4 250.00mg $545 2026-05-18 Buy
Matrix Scientific 096648 2-Chloro-5-iodothiophene 28712-49-4 1.00g $1210 2026-05-18 Buy
American Custom Chemicals Corporation HCH0363552 2-CHLORO-5-IODOTHIOPHENE 95.00% 28712-49-4 5MG $496.11 2021-12-16 Buy
Matrix Scientific 096648 2-Chloro-5-iodothiophene 95+% 28712-49-4 250mg $545 2021-12-16 Buy
Matrix Scientific 096648 2-Chloro-5-iodothiophene 95+% 28712-49-4 1g $1210 2021-12-16 Buy
Product number Packaging Price Buy
096648 250.00mg $545 Buy
096648 1.00g $1210 Buy
HCH0363552 5MG $496.11 Buy
096648 250mg $545 Buy
096648 1g $1210 Buy

2-Chloro-5-iodothiophene Chemical Properties,Uses,Production

Synthesis

2-Iodothiophene

3437-95-4

2-Chloro-5-iodothiophene

28712-49-4

The general procedure for the synthesis of 2-chloro-5-iodothiophene from 2-iodothiophene is as follows: Example 1: Synthesis of 1-(5-chlorothiophen-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol 1. 2-Iodothiophene (2.5 g, 11.9 mmol) was dissolved in hexane (25 mL) and stirred until completely dissolved. 2. N-chlorosuccinimide (NCS; 1.58 g, 11.9 mmol) was added to the above solution. 3. A catalytic amount of perchloric acid (HClO4) was added and the reaction was stirred continuously for 24 hours (h) at room temperature (RT). 4. Upon completion of the reaction, the reaction mixture was filtered and the filtrate was collected. 5. The filtrate was washed sequentially with water (H2O) and brine and then dried with anhydrous sodium sulfate (Na2SO4). 6. The dried filtrate was concentrated under vacuum to give 2-chloro-5-iodothiophene in liquid form (1.7 g, 6.9 mmol, 58% yield). Product characterization: 1H NMR (200 MHz, CDCl3): δ 7.18 (d, J = 4.2 Hz, 1H), 6.69 (d, J = 4.2 Hz, 1H).

References

[1] Journal of Organic Chemistry, 1993, vol. 58, # 11, p. 3072 - 3075
[2] Patent: US2012/329802, 2012, A1. Location in patent: Page/Page column 18-19

2-Chloro-5-iodothiophene synthesis

96-43-5
28712-49-4
Synthesis of 2-Chloro-5-iodothiophene from 2-Chlorothiophene

2-Chloro-5-iodothiophene Preparation Products And Raw materials

Raw materials

2-Iodothiophene 2-Chlorothiophene Hexane N-Chlorosuccinimide

Preparation Products

2-Chlorothiophene

2-Chloro-5-iodothiophene Suppliers

Global( 26)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4017 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9984 58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd 		+8618235132063 sales@tihondan.com China 3767 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15812 58
SuZhou Medinoah Co.,LTD. 0512-69561983 13914027025 zhang_q@medinoah.com China 3893 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 021-4009004166/18616739031 18616739031 3007523370@qq.com China 52678 58
Cool Pharm, Ltd 021-58581007 18019463053 sales@coolpharm.com China 10000 58
Supplier Advantage
Alchem Pharmtech,Inc. 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58
Coresyn Pharmatech Co., Ltd. 		58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Amadis Chemical Company Limited 		58
Aikon International Limited 58
SuZhou Medinoah Co.,LTD. 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 58
Cool Pharm, Ltd 58

28712-49-4(2-Chloro-5-iodothiophene)Related Search:

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2-Chloro-5-iodothiophene Thiophene, 2-chloro-5-iodo- 28712-49-4 C4H2ClIS