2-Chloro-5-iodothiophene
- CAS No.
- 28712-49-4
- Chemical Name:
- 2-Chloro-5-iodothiophene
- Synonyms
- 2-Chloro-5-iodothiophene;Thiophene, 2-chloro-5-iodo-
- CBNumber:
- CB22487528
- Molecular Formula:
- C4H2ClIS
- Molecular Weight:
- 244.48
- MDL Number:
- MFCD18382465
- MOL File:
- 28712-49-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H312-H315-H335-H332-H302 |
| Precautionary statements | P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P |
2-Chloro-5-iodothiophene price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | DBA71249 | 2-chloro-5-iodothiophene | 28712-49-4 | 100mg | $363 | 2026-06-04 | Buy |
| Biosynth | DBA71249 | 2-chloro-5-iodothiophene | 28712-49-4 | 1g | $944 | 2026-06-04 | Buy |
| Activate Scientific | AS44889 | 2-Chloro-5-iodothiophene 95% | 28712-49-4 | 250mg | $254 | 2026-06-04 | Buy |
| Activate Scientific | AS44889 | 2-Chloro-5-iodothiophene 95% | 28712-49-4 | 1g | $830 | 2026-06-04 | Buy |
| Matrix Scientific | 096648 | 2-Chloro-5-iodothiophene | 28712-49-4 | 250.00mg | $545 | 2026-05-18 | Buy |
2-Chloro-5-iodothiophene Chemical Properties, Uses, Production
Synthesis
3437-95-4
28712-49-4
The general procedure for the synthesis of 2-chloro-5-iodothiophene from 2-iodothiophene is as follows: Example 1: Synthesis of 1-(5-chlorothiophen-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol 1. 2-Iodothiophene (2.5 g, 11.9 mmol) was dissolved in hexane (25 mL) and stirred until completely dissolved. 2. N-chlorosuccinimide (NCS; 1.58 g, 11.9 mmol) was added to the above solution. 3. A catalytic amount of perchloric acid (HClO4) was added and the reaction was stirred continuously for 24 hours (h) at room temperature (RT). 4. Upon completion of the reaction, the reaction mixture was filtered and the filtrate was collected. 5. The filtrate was washed sequentially with water (H2O) and brine and then dried with anhydrous sodium sulfate (Na2SO4). 6. The dried filtrate was concentrated under vacuum to give 2-chloro-5-iodothiophene in liquid form (1.7 g, 6.9 mmol, 58% yield). Product characterization: 1H NMR (200 MHz, CDCl3): δ 7.18 (d, J = 4.2 Hz, 1H), 6.69 (d, J = 4.2 Hz, 1H).
References
[1] Journal of Organic Chemistry, 1993, vol. 58, # 11, p. 3072 - 3075
[2] Patent: US2012/329802, 2012, A1. Location in patent: Page/Page column 18-19
2-Chloro-5-iodothiophene Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-5-iodothiophene Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| SuZhou Medinoah Co.,LTD. | 0512-69561983 13914027025 | zhang_q@medinoah.com | China | 3925 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Cool Pharm, Ltd | 021-58581007 18019463053 | sales@coolpharm.com | China | 9999 | 58 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 | sales@mreda.com.cn | China | 19323 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55055611 18137792234 | 3957071458@qq.com | China | 9973 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4011 | 58 |
| Zhejiang Lianshuo Biotechnology Co., Ltd. | 18616526224 | lianshuo@vip.126.com | China | 9605 | 58 |
| Changzhou Yinghao Technology Development Co., Ltd | 15151934985 | sales@yingsapharm.com | China | 5455 | 58 |
