Methyl 4,6-dihydroxypyridazine-3-carboxylate
- CAS No.
- 372118-00-8
- Chemical Name:
- Methyl 4,6-dihydroxypyridazine-3-carboxylate
- Synonyms
- Methyl 4,6-dihydroxypyridazine-3-carboxylate;methyl 4-hydroxy-6-oxo-1H-pyridazine-3-carboxylate;4,6-dihydroxy-pyridazine-3-carboxylic acid methyl ester;Methyl 1,6-dihydro-4-hydroxy-6-oxo-3-pyridazinecarboxylate;methyl 4-hydroxy-6-oxo-1H-pyridazine-3-carboxylate - [M86609];3-Pyridazinecarboxylic acid, 1,6-dihydro-4-hydroxy-6-oxo-, methyl ester;3-Pyridazinecarboxylicacid,1,6-dihydro-4-hydroxy-6-oxo-,methylester(9CI)
- CBNumber:
- CB91302610
- Molecular Formula:
- C6H6N2O4
- Molecular Weight:
- 170.12
- MDL Number:
- MFCD09953611
- MOL File:
- 372118-00-8.mol
- MSDS File:
- SDS
| Density | 1.58±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.50±1.00(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C6H6N2O4/c1-12-6(11)5-3(9)2-4(10)7-8-5/h2H,1H3,(H2,7,9,10) |
| InChIKey | SHJHUIKJFYHTDY-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)=NNC(=O)C=C1O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302-H315 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
Methyl 4,6-dihydroxypyridazine-3-carboxylate price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | M86609 | methyl 4-hydroxy-6-oxo-1H-pyridazine-3-carboxylate 95% | 372118-00-8 | 100mg | $17 | 2026-05-06 | Buy |
| Synthonix | M86609 | methyl 4-hydroxy-6-oxo-1H-pyridazine-3-carboxylate 95% | 372118-00-8 | 250mg | $23 | 2026-05-06 | Buy |
| Synthonix | M86609 | methyl 4-hydroxy-6-oxo-1H-pyridazine-3-carboxylate 95% | 372118-00-8 | 1g | $60 | 2026-05-06 | Buy |
| Synthonix | M86609 | methyl 4-hydroxy-6-oxo-1H-pyridazine-3-carboxylate 95% | 372118-00-8 | 5g | $300 | 2026-05-06 | Buy |
| aablocks | AA00CIPZ | Methyl 4,6-dihydroxypyridazine-3-carboxylate 97% | 372118-00-8 | 100mg | $10 | 2026-05-28 | Buy |
Methyl 4,6-dihydroxypyridazine-3-carboxylate Chemical Properties, Uses, Production
Synthesis
83878-89-1
372118-00-8
Step 2 Synthesis of methyl 4,6-dihydroxypyridazine-3-carboxylate: dimethyl 2-diazo-3-oxoglutarate (50.0 g, 249.8 mmol) and triphenylphosphine (65.5 g, 249.8 mmol) were dissolved in ethyl ether (500 mL) and stirred at room temperature for 24 hours. After the reaction was completed, the organic solvent was removed under vacuum. Acetic acid (500 mL) and water (50 mL) were added to the residue and the reaction was refluxed for 10 hours. The reaction mixture was concentrated under reduced pressure to give a viscous residue. The residue was ground with ethyl acetate to give a yellow solid. The solid was purified by silica gel column chromatography (100-200 mesh, eluent: dichloromethane solution of 1-5% methanol) to give methyl 4,6-dihydroxypyridazine-3-carboxylate (12.8 g, 30% yield) as a yellow solid.LC-MS: m/z 169.2 [M + H]+.
References
[1] Patent: US2013/178478, 2013, A1. Location in patent: Paragraph 0299;0300
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2683 - 2691
[3] Patent: US2004/77653, 2004, A1. Location in patent: Page 18
Methyl 4,6-dihydroxypyridazine-3-carboxylate Preparation Products And Raw materials
Methyl 4,6-dihydroxypyridazine-3-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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