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4-Amino-3-nitrobenzotrifluoride

4-Amino-3-nitrobenzotrifluoride structure

CAS No.: 400-98-6

Chemical Name:: 4-Amino-3-nitrobenzotrifluoride

Synonyms: 2-NITRO-4-(TRIFLUOROMETHYL)ANILINE;2-Nitro-4-trifluoromethyl-phenylamine;BUTTPARK 75\04-39;TIMTEC-BB SBB003488;2-NITRO-ALPHA,ALPHA,A;3-NITRO-4-AMINOBENZOTRIFLUORIDE;4-AMINO-3-NITROBENZOTRIFLUORIDE;3-nitro-4-aminotrifluorotoluene;4-TRIFLUOROMETHYL 2-NITROANILINE;4-Amino-3-nitrobenzotrifluoride98%

CBNumber:: CB7735576

Molecular Formula:: C7H5F3N2O2

Molecular Weight:: 206.12

MDL Number:: MFCD00007155

MOL File:: 400-98-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:09:08

Product description	Number	Pack Size	Price
4-Amino-3-nitrobenzotrifluoride >99.0%(GC)	A0376	25g	$152
4-Amino-3-nitrobenzotrifluoride	FA103166	1g	$233.04
4-Amino-3-nitrobenzotrifluoride	FA103166	5g	$990.4
4-Amino-3-nitrobenzotrifluoride	FA103166	10g	$1584.7
4-Amino-3-nitrobenzotrifluoride >98%	PC1090	25g	$21
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4-Amino-3-nitrobenzotrifluoride Properties

Melting point	105-106 °C(lit.)
Boiling point	265.6±40.0 °C(Predicted)
Density	1.4711 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in Methanol,Toluene
pka	-2.54±0.10(Predicted)
form	Crystals or Crystalline Powder
color	Yellow to golden
BRN	650808
InChI	InChI=1S/C7H5F3N2O2/c8-7(9,10)4-1-2-5(11)6(3-4)12(13)14/h1-3H,11H2
InChIKey	ATXBGHLILIABGX-UHFFFAOYSA-N
SMILES	C1(N)=CC=C(C(F)(F)F)C=C1[N+]([O-])=O
CAS DataBase Reference	400-98-6(CAS DataBase Reference)
FDA UNII	JCH7KWT394
NIST Chemistry Reference	Aniline, 2-nitro-4-trifluoromethyl-(400-98-6)
EPA Substance Registry System	Benzenamine, 2-nitro-4-(trifluoromethyl)- (400-98-6)
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS06

Signal word

Warning

Hazard statements

H311-H301+H311+H331-H302-H312-H315-H319-H332-H335

Precautionary statements

P264-P270-P271-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P305+P351+P338+P337+P313-P403+P233-P405-P501-P280h-P309-P310-P261-P280-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38

Safety Statements

26-36/37

RIDADR

UN2811

WGK Germany

Hazard Note

Irritant

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

III

HS Code

29214300

Storage Class

13 - Non Combustible Solids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

4-Amino-3-nitrobenzotrifluoride price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A0376	4-Amino-3-nitrobenzotrifluoride >99.0%(GC)	400-98-6	25g	$152	2026-04-30	Buy
Biosynth	FA103166	4-Amino-3-nitrobenzotrifluoride	400-98-6	1g	$233.04	2026-06-04	Buy
Biosynth	FA103166	4-Amino-3-nitrobenzotrifluoride	400-98-6	5g	$990.4	2026-06-04	Buy
Biosynth	FA103166	4-Amino-3-nitrobenzotrifluoride	400-98-6	10g	$1584.7	2026-06-04	Buy
Apolloscientific	PC1090	4-Amino-3-nitrobenzotrifluoride >98%	400-98-6	25g	$21	2026-06-04	Buy

Product number	Packaging	Price	Buy
A0376	25g	$152	Buy
FA103166	1g	$233.04	Buy
FA103166	5g	$990.4	Buy
FA103166	10g	$1584.7	Buy
PC1090	25g	$21	Buy

4-Amino-3-nitrobenzotrifluoride Chemical Properties,Uses,Production

Chemical Properties

White to yellow crystal powder

Uses

4-Amino-3-nitrobenzotrifluoride can be used as pharmaceutical and pesticide intermediates.

Synthesis

Acetamide, N-[2-nitro-4-(trifluoromethyl)phenyl]-

396-12-3

400-98-6

N-(2-nitro-4-(trifluoromethyl)phenyl)acetamide (109.5 g, 0.5 mol) was used as a raw material and was mixed with 94% sulfuric acid solution (171.5 g) at a stirring rate of 550 rpm, and the reaction temperature was controlled to be 28 °C. Subsequently, 98% nitric acid solution (32.5 g, 0.51 mol) was added dropwise to the mixture at a dropwise acceleration rate of 40 g/min. After the dropwise addition, the nitrification reaction was continued for 2 hours. After completion of the reaction, the reaction system was heated to 80°C and the deacetylation reaction was carried out for 5 hours to obtain the deacetylated product. The deacetylation product was cooled to below 45°C and slowly added to ice water to precipitate the solid. The resulting solid was filtered and washed, followed by alkaline washing with 10% aqueous sodium hydroxide solution until the pH of the filtrate reached 7, terminating the alkaline washing process. The alkali washed solid was dried at 55 °C for 4.5 h. 104 g of 4-trifluoromethoxy-2-nitroaniline was finally obtained, which was analyzed by GC with a purity of 98.5% and a yield of 94%.

References

[1] Kogyo Kagaku Zasshi, 1959, vol. 62, p. 706,708
[2] Chem. Zentralbl., 1960, vol. 131, p. 7854
[3] Journal of Medicinal Chemistry, 1995, vol. 38, # 10, p. 1786 - 1792
[4] Organic and Biomolecular Chemistry, 2016, vol. 14, # 9, p. 2645 - 2650
[5] Patent: CN107032965, 2017, A. Location in patent: Paragraph 0081; 0084; 0085; 0095; 0099; 0100; 0111; 0112

4-Amino-3-nitrobenzotrifluoride Preparation Products And Raw materials

Raw materials

Acetamide, N-[2-nitro-4-(trifluoromethyl)phenyl]-

Preparation Products

2-NITRO-4-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE 2-amino-alpha,alpha,alpha-trifluoro-p-creso 2-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID 4-Hydroxy-3-nitrobenzotrifluoride (2-Nitro-4-trifluoroMethyl-phenyl)-carbaMic acid tert-butyl ester

N-[2-Nitro-4-(trifluoroMethyl)phenyl]benzenesulfonaMide, 97% 1H-BENZIMIDAZOLE, 2-PHENYL-5-(TRIFLUOROMETHYL)- N1-[2-AMINO-4-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE 6-trifluoroMethyl-8-quinolinaMine

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4-Amino-3-nitrobenzotrifluoride Suppliers

Global( 301)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 17389186172	1077@dideu.com	China	3999	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1444	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114	sales@amoychem.com	China	6339	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1056@dideu.com	China	3970	58
Fuxin Pharmaceutical	+86-021-021-50872116	contact@fuxinpharm.com	China	9976	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Capot Chemical Co.,Ltd.	60
Fluoropharm Co., Ltd.	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Xiamen AmoyChem Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Fuxin Pharmaceutical	58
SIMAGCHEM CORP	58

View Lastest Price from 4-Amino-3-nitrobenzotrifluoride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-07	4-Amino-3-nitrobenzotrifluoride 400-98-6	$1.00-12.00	1KG	99%	1000KG	Shaanxi Dideu Medichem Co. Ltd
2026-06-30	4-Amino-3-nitrobenzotrifluoride 400-98-6		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-02-02	4-Amino-3-nitrobenzotrifluoride 400-98-6		50mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd

4-Amino-3-nitrobenzotrifluoride
400-98-6
$1.00-12.00
99%
Shaanxi Dideu Medichem Co. Ltd

4-Amino-3-nitrobenzotrifluoride
400-98-6
98.0%
Shaanxi Dideu New Materials Co. Ltd

4-Amino-3-nitrobenzotrifluoride
400-98-6
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

4-Amino-3-nitrobenzotrifluoride Spectrum

4-Amino-3-nitrobenzotrifluoride(400-98-6)MS 4-Amino-3-nitrobenzotrifluoride(400-98-6)¹HNMR 4-Amino-3-nitrobenzotrifluoride(400-98-6)¹³CNMR 4-Amino-3-nitrobenzotrifluoride(400-98-6)IR1 4-Amino-3-nitrobenzotrifluoride(400-98-6)IR2

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2-Nitro-α,α,α-trifluoro-p-toluidine, 4-Amino-3-nitrobenzotrifluoride α,α,α-Trifluoro-2-nitro-p-toluidine 2-Nitro-4-(trifluoromethyl)benzenamine 2-NITRO-ALPHA,ALPHA,A 4-AMino-3-nitrobenzotrifluoride, 98% 25GR 2-Nitro-4-(trifluoromethyl)aniline, 2-Amino-5-(trifluoromethyl)nitrobenzene 2-Nitro-4-trifluoromethyl-phenylamine alpha,alpha,alpha-Trifluoro-2-nitro-p-toluidine Benzenamine, 2-nitro-4-(trifluoromethyl)- p-Toluidine, alpha,alpha,alpha-trifluoro-2-nitro- 4-TRIFLUOROMETHYL 2-NITROANILINE TIMTEC-BB SBB003488 2-NITRO-A,A,A-TRIFLUORO-P-TOLUIDINE 2-NITRO-ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLUIDINE 3-NITRO-4-AMINOBENZOTRIFLUORIDE 3-NITRO-4-AMINOTRIFLUOROMETHYLBENZENE 3-NITRO-A,A,A-TRIFLUORO-P-TOLUIDINE A,A,A-TRIFLUORO-2-NITRO-P-TOLUIDINE 4-AMINO-3-NITROBENZOTRIFLUORIDE BUTTPARK 75\04-39 4-Amino-3-nitrobenzotrifluoride, 98% (2-Nitro-4-trifluoromethylaniline) 4-Amino-3-nitro-1-(trifluoromethyl)benzene 2-nitro-α,α,α-trifluoro-p-toluidine 4-Amino-3-nitrobenzotrifluoride 98% 4-Amino-3-nitrobenzotrifluoride98% 2-NITRO-4-(TRIFLUOROMETHYL)BENZAMINE 4-Amino-3-nitrobenzotrifluoride > ?,?,?-trifluoro-2-nitro-p-toluidine 3-nitro-4-aminotrifluorotoluene 2-NITRO-4-(TRIFLUOROMETHYL)ANILINE 400-98-6 Nitrogen Compounds Organic Building Blocks C7 Building Blocks Amines Amines Anilines, Aromatic Amines and Nitro Compounds Aniline Trifluoromethylbenzene serise