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ZK118182 isopropyl ester

CAS No.
154927-31-8
Chemical Name:
ZK118182 isopropyl ester
Synonyms
ZK118182 isopropyl ester;QLJUNFBXIBNQOL-LMJZMJOFSA-N;ZK118182 isopropyl ester Exclusive;ZK118182 isopropyl ester,ZK-118182 isopropyl ester;propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate;Acetic acid, [[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]-3-hydroxycyclopentyl]-2-butenyl]oxy]-, 1-methylethyl ester (9CI)
CBNumber:
CB22592893
Molecular Formula:
C23H37ClO5
Molecular Weight:
428.99
MDL Number:
MFCD00929952
MOL File:
154927-31-8.mol
Last updated:2025-04-17 18:22:24

ZK118182 isopropyl ester Properties

Boiling point 553.1±50.0 °C(Predicted)
Density 1.14±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
pka 14.22±0.70(Predicted)

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Risk and Safety Statements

ZK118182 isopropyl ester price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13673 ZK118182 isopropyl ester ≥98% 154927-31-8 100μg $208 2024-03-01 Buy
Cayman Chemical 13673 ZK118182 isopropyl ester ≥98% 154927-31-8 500μg $925 2024-03-01 Buy
TRC Z485905 ZK118182isopropylester 154927-31-8 250μg $450 2021-12-16 Buy
American Custom Chemicals Corporation HCH0068932 ((4-(5R-CHLORO-2Z-(3R-CYCLOHEXYL-3S-HYDROXY-1R-PROPENYL)-3S-HYDROXYCYCLOPENTYL)-2R-BUTENYL)OXY)-ACETIC ACID-1E-METHYLETHYL ESTER 95.00% 154927-31-8 5MG $499.16 2021-12-16 Buy
Product number Packaging Price Buy
13673 100μg $208 Buy
13673 500μg $925 Buy
Z485905 250μg $450 Buy
HCH0068932 5MG $499.16 Buy

ZK118182 isopropyl ester Chemical Properties,Uses,Production

Description

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.

Uses

ZK118182 Isopropyl ester is the isopropyl ester analog of ZK118182, a prostaglandin analog[1].

References

[1] Sharif N A, et al. Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes[J]. Journal of Ocular Pharmacology & Therapeutics, 2004, 20(6): 489-508.

ZK118182 isopropyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

ZK118182 isopropyl ester Suppliers

Global( 22)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38664 58
BOC Sciences 16314854226 info@bocsci.com United States 9923 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029 synstar518@163.com China 1990 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44813 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24865 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Cayman Chemical Company 800-364-9897 sales@caymanchem.com China 27736 58

View Lastest Price from ZK118182 isopropyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ZK118182 isopropyl ester pictures 2024-10-28 ZK118182 isopropyl ester
154927-31-8
US $2310.00 / μg 10g TargetMol Chemicals Inc.
ZK118182 isopropyl ester QLJUNFBXIBNQOL-LMJZMJOFSA-N ZK118182 isopropyl ester Exclusive propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate Acetic acid, [[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]-3-hydroxycyclopentyl]-2-butenyl]oxy]-, 1-methylethyl ester (9CI) ZK118182 isopropyl ester,ZK-118182 isopropyl ester 154927-31-8 C23H37ClO5