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ChemicalBook >> CAS DataBase List >>Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]-

Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]-

Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- Structure
Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- structure
CAS No.
862281-92-3
Chemical Name:
Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]-
Synonyms
PF00446687,PF 00446687;[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[(3S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl]methanone;Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]-
CBNumber:
CB22628095
Molecular Formula:
C28H36F2N2O2
Molecular Weight:
470.59
MDL Number:
MFCD18251471
MOL File:
862281-92-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-11 19:39:08
Request For Quotation

Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- Properties

Boiling point 571.9±50.0 °C(Predicted)
Density 1.167±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 62.5 mg/mL (132.81 mM)
form Solid
pka 13.86±0.60(Predicted)
color White to off-white
FDA UNII 63P236Z73I

Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 41739 PF-00446687 ≥98% 862281-92-3 1mg $164 2026-04-30 Buy
Cayman Chemical 41739 PF-00446687 ≥98% 862281-92-3 5mg $656 2026-04-30 Buy
Biosynth MJB28192 PF-00446687 862281-92-3 5mg $985.2 2026-06-04 Buy
Biosynth MJB28192 PF-00446687 862281-92-3 10mg $1395.7 2026-06-04 Buy
Biosynth MJB28192 PF-00446687 862281-92-3 25mg $1784.75 2026-06-04 Buy
Product number Packaging Price Buy
41739 1mg $164 Buy
41739 5mg $656 Buy
MJB28192 5mg $985.2 Buy
MJB28192 10mg $1395.7 Buy
MJB28192 25mg $1784.75 Buy

Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- Chemical Properties, Uses, Production

Uses

PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12±1 nM[1]. Pf-446687 is brain penetrant[2].

in vivo

Pf-446687 is highly selective for MC4R and is both brain penetrant and stable in vivo. Peripheral administration of the brain penetrant MC3/4R receptor peptide agonist, Melanotan II (MTII), and the highly selective, small molecule MC4R agonist, Pf-446687, enhances partner preference formation in the prairie vole, but not in the non-monogamous meadow vole[2].

IC 50

MC4R

References

[1] Lansdell MI, et al. Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans. J Med Chem. 2010 Apr 22;53(8):3183-97. DOI:10.1021/jm9017866
[2] Modi ME, et al. Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole. Neuropsychopharmacology. 2015 Jul;40(8):1856-65. DOI:10.1038/npp.2015.35

Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- Suppliers

Global Suppliers ( 18)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 28150 68
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Kaifeng Mingren Pharmaceutical Co.,LTD 0371-65741762 sales@hasunny.com China 2377 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2934 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Supplier Advantage
BOC Sciences 65
Shanghai YuanYe Biotechnology Co., Ltd. 60
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Fan De(Beijing) Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Kaifeng Mingren Pharmaceutical Co.,LTD 58
TargetMol Chemicals Inc. 58
Shanghai Tachizaki Biomedical Research Center 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Latest Price from Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PF-00446687 pictures 2026-05-11 PF-00446687
862281-92-3
 $297.00-1360.00 10g TargetMol Chemicals Inc.
  • PF-00446687 pictures
  • PF-00446687
    862281-92-3
  • $297.00-1360.00
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862281-92-3 (Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]-) Related Search:

PF-5190457 PF-04995274 PF-3274167 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile Tavapadon
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Methanone, [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-diMethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-diMethyl-4-phenyl-1-piperidinyl]- [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[(3S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl]methanone PF00446687,PF 00446687 862281-92-3 C28H36F2N2O2