Tavapadon
- CAS No.
- 1643489-24-0
- Chemical Name:
- Tavapadon
- Synonyms
- CVL-751;Tavapadon;PF 6649751;Tavapadon (CVL-751);Tavapadon(PF-06649751;Tavapadon, 10 mM in DMSO;CVL751,CVL 751,inhibit,PF 06649751,Tavapadon,Inhibitor,PF-06649751,Dopamine Receptor,PF06649751;1,5-dimethyl-6-[2-methyl-4-[[3-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]-2,4(1H,3H)-pyrimidinedione;(-)-1,5-Dimethyl-6-(2-methyl-4-((3-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)pyrimidine-2,4(1H,3H)-dione;(-)-1,5-Dimethyl-6-[2-methyl-4-[[3-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]-2,4(1H,3H)-pyrimidinedione (ACI)
- CBNumber:
- CB94668591
- Molecular Formula:
- C19H16F3N3O3
- Molecular Weight:
- 391.35
- MDL Number:
- MFCD32669809
- MOL File:
- 1643489-24-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.332±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | -20°C |
| solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml,Ethanol: 2 mg/ml |
| form | A crystalline solid |
| pka | 9.54±0.40(Predicted) |
| color | White to light yellow |
| InChI | InChI=1S/C19H16F3N3O3/c1-10-9-12(28-17-14(19(20,21)22)5-4-8-23-17)6-7-13(10)15-11(2)16(26)24-18(27)25(15)3/h4-9H,1-3H3,(H,24,26,27) |
| InChIKey | AKQXQLUNFKDZBN-UHFFFAOYSA-N |
| SMILES | CC1C=C(OC2N=CC=CC=2C(F)(F)F)C=CC=1C1N(C(=O)NC(=O)C=1C)C |
| FDA UNII | PT4P8MJP8L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H311-H331 |
| Precautionary statements | P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501 |
Tavapadon price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 33556 | PF-06649751 ≥98% | 1643489-24-0 | 5mg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 33556 | PF-06649751 ≥98% | 1643489-24-0 | 10mg | $84 | 2026-04-30 | Buy |
| Cayman Chemical | 33556 | PF-06649751 ≥98% | 1643489-24-0 | 25mg | $185 | 2026-04-30 | Buy |
| Cayman Chemical | 33556 | PF-06649751 ≥98% | 1643489-24-0 | 50mg | $304 | 2026-04-30 | Buy |
| Biosynth | TQC48924 | Tavapadon | 1643489-24-0 | 5mg | $778.8 | 2026-06-05 | Buy |
Tavapadon Chemical Properties, Uses, Production
Uses
Tavapadon (PF-06649751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist. Tavapadon is effective in enabling movement and reducing disability and has the potential for Parkinson's disease[1].
in vivo
Tavapadon (PF-06649751; 0.02 and 0.04 mg/kg; s.c.) at the 0.04 mg/kg test dose increases locomotor activity, whereas the 0.02 mg/kg dose has little or no effect[1].
Tavapadon (0.04 mg/kg, s.c.) also improves parkinsonian disability scores with the maximal improvement observed at 110 min after drug administration[1].
Higher doses of Tavapadon (0.1 and 0.15 mg/kg; s.c.) leads to statistically significant improvement relative to vehicle in locomotor activity[1].
Tavapadon (0.1 mg/kg; s.c.) has the mean maximal unbound plasma concentration of 8 nM and achieves 3 hours after compound administration in captive-bred macaques[1].
References
[1] Young D, et al. D1 Agonist Improved Movement of Parkinsonian Nonhuman Primates with Limited DyskinesiaSide Effects. ACS Chem Neurosci. 2020 Feb 19;11(4):560-566. DOI:10.1021/acschemneuro.9b00589
Tavapadon Preparation Products And Raw materials
Raw materials
Preparation Products
Tavapadon Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Tengyi Biotechnology Co., Ltd | 17714337195 | sales@tybiochem.com | China | 683 | 58 |
| Taizhou Nanfeng Pharmaceutical Research Institute | nanfengpharma@126.co 18616377689 | nanfengpharma@126.com | China | 20008 | 58 |
| Changzhou Yongfeng Biomedicine Co. Ltd. | 15006117673 | 2973592490@qq.com | China | 270 | 58 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3980 | 55 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9711 | 58 |
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