MTEP
- CAS No.
- 1186195-60-7
- Chemical Name:
- MTEP
- Synonyms
- MTEP HCl;3-((2-Methyl-1;MTEP hydrochloride, mGlu5 antagonist;MTEP hydrochloride (mM/ml), mGlu5 antagonist;3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride;2-Methyl-4-(pyridin-3-ylethynyl)thiazole hydrochloride;3-[2-(2-Methyl-4-thiazolyl)ethynyl]pyridine hydrochloride (1:1);3-((2-METHYL-1;3-THIAZOL-4-YL)ETHYN-YL)PYRIDINE HYDROCHLORIDE;MTEP;Metabotropic glutamate receptors,mGluR,inhibit,Inhibitor,MTEP hydrochloride;3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine, 3-[(2-Methyl-4-thiazolyl)ethynyl]pyridine
- CBNumber:
- CB22628565
- Molecular Formula:
- C11H9ClN2S
- Molecular Weight:
- 236.72056
- MDL Number:
- MFCD08458895
- MOL File:
- 1186195-60-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 154-156℃ (isopropanol ) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | crystalline solid |
| color | Light cream |
| Water Solubility | H2O: 30mg/mL, clear |
| InChI | 1S/C11H8N2S.ClH/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10;/h2-3,6-8H,1H3;1H |
| InChIKey | YCIOJDKGCWAHLR-UHFFFAOYSA-N |
| SMILES | Cl.Cc1nc(cs1)C#Cc2cccnc2 |
| FDA UNII | PW4B4S8XAB |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
MTEP price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M4699 | MTEP hydrochloride ≥98% (HPLC) | 1186195-60-7 | 5 mg | $162 | 2026-04-30 | Buy |
| Sigma-Aldrich | M4699 | MTEP hydrochloride ≥98% (HPLC) | 1186195-60-7 | 25 mg | $642 | 2026-04-30 | Buy |
| Cayman Chemical | 14961 | MTEP (hydrochloride) ≥98% | 1186195-60-7 | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 14961 | MTEP (hydrochloride) ≥98% | 1186195-60-7 | 5mg | $73 | 2024-03-01 | Buy |
| TRC | TRC-M759900-50MG | MTEP Hydrochloride | 1186195-60-7 | 50mg | $359 | 2026-06-03 | Buy |
MTEP Chemical Properties, Uses, Production
Description
Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-
Uses
MTEP Hydrochloride is a potent mGlu5 receptor antagonist, acting as a negative allosteric modulator.
in vitro
like mpep, mtep showed a nanomolar affinity for mglur5, but seemed to be superior to mpep in term of specificity. mtep did not influence mglur2, mglur7, nmda, ampa or kainate receptors, while inhibited maoa at a concentration three times higher than mpep. moreover, recent study indicated that mtep was five times stronger that mpep as an anxiolytic compound [1].
in vivo
mtep with doses between 0.5 and 3 mg/kg was found to decrease the haloperidol-induced muscle rigidity, which was measured as an increased muscle resistance of the rat hind leg. the longest and strongest effect was observed with the dose of 1 mg/kg. mtep was also found to reduce the haloperidol-induced increase in electromyographic activity recorded in the tibialis anterior and gastrocnemius muscles. 3 and 5 mg/kg of mtep could inhibit the haloperidol- induced catalepsy [1].
IC 50
5 nm
storage
+4°C (desiccate)
References
[1] ossowska k,konieczny j,wolfarth s,pilc a. mtep, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mglur5), produces antiparkinsonian-like effects in rats. neuropharmacology.2005 sep;49(4):447-55.
MTEP Preparation Products And Raw materials
Raw materials
Preparation Products
MTEP Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 1999 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4975 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3853 | 58 |
View Latest Price from MTEP manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | MTEP hydrochloride
1186195-60-7
|
$35.00-90.00 | 99.58% | 10g | TargetMol Chemicals Inc. |
-
- MTEP hydrochloride
1186195-60-7
- $35.00-90.00
- 99.58%
- TargetMol Chemicals Inc.
