CAL 130
- CAS No.
- 1431697-74-3
- Chemical Name:
- CAL 130
- Synonyms
- CAL130; CAL 130;4(3H)-Quinazolinone, 2-[(1S)-1-[(2-amino-9H-purin-6-yl)amino]ethyl]-5-methyl-3-(2-methylphenyl)-;2-?[(1S)?-?1-?[(2-?Amino-?9H-?purin-?6-?yl)?amino]?ethyl]?-?5-?methyl-?3-?(2-?methylphenyl)?-4(3H)?-?quinazolinone
- CBNumber:
- CB22666604
- Molecular Formula:
- C23H22N8O
- Molecular Weight:
- 426.47
- MDL Number:
- MFCD25372030
- MOL File:
- 1431697-74-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
CAL 130 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | GHC69774 | 2-[(1S)-1-[(2-Amino-9H-purin-6-yl)amino]ethyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone | 1431697-74-3 | 25mg | $1361.5 | 2026-06-04 | Buy |
| Biosynth | GHC69774 | 2-[(1S)-1-[(2-Amino-9H-purin-6-yl)amino]ethyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone | 1431697-74-3 | 50mg | $1893.5 | 2026-06-04 | Buy |
| Crysdot | CD31003510 | CAL-130 98+% | 1431697-74-3 | 5mg | $186 | 2026-05-27 | Buy |
| Crysdot | CD31003510 | CAL-130 98+% | 1431697-74-3 | 10mg | $240 | 2026-05-27 | Buy |
| Crysdot | CD31003510 | CAL-130 98+% | 1431697-74-3 | 50mg | $648 | 2026-05-27 | Buy |
CAL 130 Chemical Properties, Uses, Production
Uses
CAL-130 is a PI3Kδ and PI3Kγ inhibitor with IC50s of 1.3 and 6.1 nM, respectively.
in vivo
The clinical significance of interfering with the combined activities of PI3Kγ and PI3Kδ is determined by administering CAL-130 to Lck/Ptenfl/fl mice with established T cell acute lymphoblastic leukemia (T-ALL). Candidate animals for survival studies are ill appearing, have a white blood cell (WBC) count above 45,000 μL-1, evidence of blasts on peripheral smear, and a majority of circulation cells (>75%) staining double positive for Thy1.2 and Ki-67. Mice receive an oral dose (10 mg/kg) of CAL-130 every 8 hr for a period of 7 days and are then followed until moribund. Despite the limited duration of therapy, CAL-130 is highly effective in extending the median survival for treated animals to 45 days as compared 7.5 days for the control group[1].
IC 50
p110δ: 1.3 nM (IC50); p110γ: 6.1 nM (IC50); p110β: 56 nM (IC50); p110α: 115 nM (IC50)
References
[1] Subramaniam Prem S, et al. Targeting nonclassical oncogenes for therapy in T-ALL. Cancer cell (2012), 21(4), 459-72. DOI:10.1016/j.ccr.2012.02.029
CAL 130 Preparation Products And Raw materials
Raw materials
Preparation Products
CAL 130 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| Chengdu Huachun Technology Co., Ltd | 400-1166-196 15982826727 | cdhxsj@163.com | China | 14571 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4648 | 60 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Beijing xinyanhui pharmaceutical research and development co., LTD | 13969155946 | 1461866103@qq.com | China | 16103 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
View Latest Price from CAL 130 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | CAL-130
1431697-74-3
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2026-07-27 | CAL-130
1431697-74-3
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-08-22 | CAL-130
1431697-74-3
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
