NVP-BEZ 235
- CAS No.
- 915019-65-7
- Chemical Name:
- NVP-BEZ 235
- Synonyms
- Dactolisib;104794;CS-381;BEZ-235;RTB-101;NVP-BEZ 235;BEZ235 0.6G;BEZ235, >=98%;NVP-BEZ235-NX;NVP-BEZ235-ANA
- CBNumber:
- CB01872365
- Molecular Formula:
- C30H23N5O
- Molecular Weight:
- 469.55
- MDL Number:
- MFCD10565944
- MOL File:
- 915019-65-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 288-289°C |
|---|---|
| Boiling point | 701.0±70.0 °C(Predicted) |
| Density | 1.299 |
| storage temp. | Refrigerator |
| solubility | Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75C). |
| form | White powder. |
| pka | 6.41±0.20(Predicted) |
| color | White or off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month. |
| InChI | InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3 |
| InChIKey | JOGKUKXHTYWRGZ-UHFFFAOYSA-N |
| SMILES | O=C1N(C2C=NC3=CC=C(C4C=NC5C=CC=CC=5C=4)C=C3C=2N1C1C=CC(C(C)(C)C#N)=CC=1)C |
| CAS DataBase Reference | 915019-65-7 |
| FDA UNII | RUJ6Z9Y0DT |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| NFPA 704 |
|
NVP-BEZ 235 price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10565 | NVP-BEZ235 ≥98% | 915019-65-7 | 25mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 10565 | NVP-BEZ235 ≥98% | 915019-65-7 | 50mg | $86 | 2026-04-30 | Buy |
| Cayman Chemical | 10565 | NVP-BEZ235 ≥98% | 915019-65-7 | 100mg | $152 | 2026-04-30 | Buy |
| Cayman Chemical | 10565 | NVP-BEZ235 ≥98% | 915019-65-7 | 250mg | $259 | 2026-04-30 | Buy |
| TRC | TRC-N925750-50MG | NVP-BEZ 235 | 915019-65-7 | 50mg | $84 | 2026-06-03 | Buy |
NVP-BEZ 235 Chemical Properties, Uses, Production
Description
NVP-BEZ235 (915019-65-7) is a dual PI3K and mTOR kinase inhibitor.1It inhibits VEGF-induced proliferation and angiogenesis.2Reverses lapatinib resistance.3It induces G1 arrest and reduces cyclin D1 expression in melanoma cells with negligible apoptosis.4NVP-BEZ235 inhibits the growth of cancer cells with activating PI3K mutations.5The ability of NVP-BEZ235 to inhibit PI3K has come into question. This study also shows it to be a potent inhibitor of PRKDC (IC50 = 29 nM), ATM (IC50 = 13 nM), and ATR (IC50 = 8 nM).6Active in vivo.
Chemical Properties
Light Beige Solid
Uses
A dual ATP-competitive inhibitor of PI3K and mTOR. p110α, IC50=4 nM; p110β, IC50=75 nM; p110δ, IC50=7 nM; p110γ, IC50=5 nM.
Uses
Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. NVP-BEZ235 is a potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies. It inhibits PI3K isoforms and mutants with low nanomolar IC50 values, leading to growth arrest in the G1 phase. Through its effects on PI3K, NVP-BEZ235 inhibits VEGF-induced angiogenesis. By directly blocking cell growth and indirectly inhibiting angiogenesis, it has potential in both solid tumors and in metastatic melanoma therapy.[Cayman Chemical]
Uses
Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR.
Definition
ChEBI: An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.
in vivo
BEZ235 induced tumor regression (69%) without a statistically significant effect on weight gain. Taken together, these preliminary in vivo efficacy findings suggest that BEZ235 blocks disease progression when administered orally alone and enhances efficacy when combined with other anticancer drugs.
target
p110α
Background
NVP-BEZ235 is a selective and potent dual inhibitor of PI3 kinase and mTOR Ser/Thr protein kinase. Research studies show that NVP-BEZ235 reversibly inhibits the catalytic activity of these kinases by competing with ATP at the ATP-binding site. Studies demonstrate that NVP-BEZ235 has anti-proliferative characteristics and induces cell cycle arrest during G0/G1 phase through inhibition of CDK4 and cyclin D3.
References
[1] SAUVEUR-MICHEL MAIRA. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity.[J]. Molecular Cancer Therapeutics, 2008, 7 7: 1851-1863. DOI:10.1158/1535-7163.mct-08-0017
[2] CHRISTIAN R SCHNELL. Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging.[J]. Cancer research, 2008: 6598-6607. DOI:10.1158/0008-5472.can-08-1044
[3] PIETER J A EICHHORN. Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.[J]. Cancer research, 2008, 68 22: 9221-9230. DOI:10.1158/0008-5472.can-08-1740
[4] ROMINA MARONE. Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors.[J]. Molecular Cancer Research, 2009, 7 4: 601-613. DOI:10.1158/1541-7786.mcr-08-0366
[5] VIOLETA SERRA. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.[J]. Cancer research, 2008: 8022-8030. DOI:10.1158/0008-5472.can-08-1385
[6] MARIA REINECKE. Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors[J]. ACS Chemical Biology, 2019, 14 4: 655-664. DOI:10.1021/acschembio.8b01020
NVP-BEZ 235 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Luofa Biochemical Technology Co., Ltd. | 021-51111890 15317326293 | sales@molnova.com | China | 4183 | 58 |
| Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | 1276242629@qq.com | China | 9977 | 58 |
| Jinan shenlikang chemical technology co. LTD | 0531-86092839 15318817273 | 2425815073@qq.com | China | 250 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
View Latest Price from NVP-BEZ 235 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-30 | Dactolisib
915019-65-7
|
$52.00-108.00 | 99.85% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-02 | NVP-BEZ 235
915019-65-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | NVP-BEZ 235
915019-65-7
|
$1.00 | 1G | 98% | 100KG | Career Henan Chemical Co |
-
- Dactolisib
915019-65-7
- $52.00-108.00
- 99.85%
- TargetMol Chemicals Inc.
-
- NVP-BEZ 235
915019-65-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- NVP-BEZ 235
915019-65-7
- $1.00
- 98%
- Career Henan Chemical Co
