SRPK inhibitor
- CAS No.
- 218156-96-8
- Chemical Name:
- SRPK inhibitor
- Synonyms
- CS-910;SRPIN340;SRPIN 340;SRPIN-340;SRPK inhibitor;SRPIN340, >=98%;SRPIN340 >=98% (HPLC);SRPIN340, 10 mM in DMSO;SRPK Inhibitor(SRPIN340);SRPIN340 (SRPK inhibitor)
- CBNumber:
- CB22668305
- Molecular Formula:
- C18H18F3N3O
- Molecular Weight:
- 349.35
- MDL Number:
- MFCD00116244
- MOL File:
- 218156-96-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| SRPIN340 ≥98% (HPLC) | SML1088 | 5mg | $129 |
| SRPIN340 ≥98% (HPLC) | SML1088 | 25mg | $489 |
| SRPK Inhibitor, SRPIN340 - CAS 281856-96-8 - Calbiochem | 5.04293 | 10mg | $204 |
| SRPIN340 ≥95% | 16284 | 1mg | $36 |
| SRPIN340 ≥95% | 16284 | 5mg | $95 |
| More product size | |||
| Boiling point | 395.9±42.0 °C(Predicted) |
|---|---|
| Density | 1.306±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | 11.09±0.70(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| InChI | 1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25) |
| InChIKey | DWFGGOFPIISJIT-UHFFFAOYSA-N |
| SMILES | O=C(C1=CC=NC=C1)NC2=C(N3CCCCC3)C=CC(C(F)(F)F)=C2 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
SRPK inhibitor price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1088 | SRPIN340 ≥98% (HPLC) | 218156-96-8 | 5mg | $129 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1088 | SRPIN340 ≥98% (HPLC) | 218156-96-8 | 25mg | $489 | 2025-07-31 | Buy |
| Sigma-Aldrich | 5.04293 | SRPK Inhibitor, SRPIN340 - CAS 281856-96-8 - Calbiochem | 218156-96-8 | 10mg | $204 | 2023-01-07 | Buy |
| Cayman Chemical | 16284 | SRPIN340 ≥95% | 218156-96-8 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 16284 | SRPIN340 ≥95% | 218156-96-8 | 5mg | $95 | 2026-04-30 | Buy |
SRPK inhibitor Chemical Properties,Uses,Production
Description
Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-
Uses
SRPIN340 is a SRPK1 kinase inhibitor, which shows potential novel targeted therapeutic strategy in prostate cancer.
Synthesis
1496-40-8
39178-35-3
218156-96-8
The general procedure for the synthesis of N-(2-(1-piperidinyl)-5-(trifluoromethyl)phenyl)isonicotinamide from 2-piperidin-1-yl-5-(trifluoromethyl)aniline and isocyanidinium chloride is as follows: isonicotinic acid chloride hydrochloride (6.48 g, 36.4 mmol, commercially available) and triethylamine (5.57 ml, 54.6 mmol) are sequentially added at 0°C to the 2-(1-piperidinyl)-5-(trifluoromethyl)aniline (4.45 g, 18.2 mmol, prepared as described in Reference Examples 1-2B) to a solution of methylene chloride (10 ml). The reaction mixture was stirred for 30 minutes. Subsequently, water was added to the mixture and extracted three times with ethyl acetate. The organic layers were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (200 g silica gel, eluent ratio hexane/ethyl acetate = 1/1) and recrystallized. The final N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide (SRPIN-1, GIF-0340) (5.49 g, 86.3% yield) was obtained as a colorless solid.
Background
Serine/arginine-rich protein-specific kinases 1 and 2 phosphorylate and regulate serine/arginine-rich proteins that bind and regulate mRNA splicing, playing an important role in post-transcriptional regulation. The small-molecule SRPIN340 is an SRPK inhibitor that is highly selective for SRPK1 and SRPK2. SRPK dysregulation can alter SR protein activity and promote expression of splicing isoforms, leading to increased viral infection or tumorigenic processes. Inhibition of SRPK1 and SRPK2 by SRPIN340 reduces SRp75 protein phosphorylation, leading to suppressed Sindbis virus propagation and reduced HIV production. Dose-dependent suppression of hepatitis C virus replication by the inhibitor SRPIN340 has been seen in vitro. SRPIN340 treatment of leukemia cells triggered early and late events of apoptosis, and reduced myeloid and lymphoid leukemia cell viability. Suppression of VEGF by SRPIN340 inhibited choroidal neovascularization formation in a mouse model, suggesting a possible role for SRPIN340 in treating neovascular age-related macular degeneration.
References
[1] TAKESHI FUKUHARA. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006: 11329-11333. DOI:10.1073/pnas.0604616103
[2] MELISSA V R GAMMONS. SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity.[J]. ACS Applied Materials & Interfaces, 2013: 5797-5806. DOI:10.1167/iovs.13-11634
[3] M V GAMMONS. Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma[J]. British Journal of Cancer, 2014, 111 3: 477-485. DOI:10.1038/bjc.2014.342
SRPK inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 | contact@trustwe.com | China | 5742 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 | sales@shengdapharm.com | CHINA | 310 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9976 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11674 | 58 |
View Lastest Price from SRPK inhibitor manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | SRPIN340
218156-96-8
|
$39.00-107.00 | 99.87% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | SRPK inhibitor
218156-96-8
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-09-06 | SRPK inhibitor
218156-96-8
|
$1.00 | 1KG | 98% | 20kg | Career Henan Chemical Co |
-
- SRPIN340
218156-96-8
- $39.00-107.00
- 99.87%
- TargetMol Chemicals Inc.
-
- SRPK inhibitor
218156-96-8
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- SRPK inhibitor
218156-96-8
- $1.00
- 98%
- Career Henan Chemical Co
