2-Methoxyestradiol
- CAS No.
- 362-07-2
- Chemical Name:
- 2-Methoxyestradiol
- Synonyms
- 2-MeOE2;2-Methoxy-β-estradiol;2-Methoxy 17β-Estradiol;2-ME2;Panzem;NSC 659853;Methoxy estradiol;7-Methoxyestradiol;2-Methoxyestradiol;2-METHOXYOESTRADIOL
- CBNumber:
- CB5268052
- Molecular Formula:
- C19H26O3
- Molecular Weight:
- 302.41
- MDL Number:
- MFCD00010489
- MOL File:
- 362-07-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 188-190°C |
|---|---|
| Boiling point | 464.4±45.0 °C(Predicted) |
| Density | 1.178±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO: 10 mg/mL |
| form | crystalline |
| pka | 10.29±0.60(Predicted) |
| color | light yellow |
| λmax | 286nm(EtOH)(lit.) |
| InChI | InChI=1/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/s3 |
| InChIKey | CQOQDQWUFQDJMK-SSTWWWIQSA-N |
| SMILES | C[C@@]12[C@H](CC[C@@]1([H])[C@]1([H])CCC3C=C(O)C(OC)=CC=3[C@@]1([H])CC2)O |&1:1,2,5,7,20,r| |
| CAS DataBase Reference | 362-07-2(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | 2-methoxyestradiol |
| FDA UNII | 6I2QW73SR5 |
| NCI Drug Dictionary | 2-methoxyestradiol |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331-H315-H319-H335-H350-H360-H372-H410 | |||||||||
| Precautionary statements | P273-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | T,Xi,N | |||||||||
| Risk Statements | 23/24/25-36/37/38-48-61-60-46-45-51/53 | |||||||||
| Safety Statements | 22-26-36/37/39-45-53-36-61 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KG7537500 | |||||||||
| HS Code | 2937.23.5050 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 Carc. 1B Eye Irrit. 2 Repr. 1B Skin Irrit. 2 STOT RE 1 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Methoxyestradiol price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 454180 | 2-Methoxyestradiol | 362-07-2 | 10mg | $105 | 2026-04-30 | Buy |
| Sigma-Aldrich | 454180 | 2-Methoxyestradiol | 362-07-2 | 50mg | $391 | 2026-04-30 | Buy |
| TCI Chemical | M2530 | 2-Methoxy-β-estradiol >97.0%(GC) | 362-07-2 | 25mg | $32 | 2026-04-30 | Buy |
| TCI Chemical | M2530 | 2-Methoxy-β-estradiol >97.0%(GC) | 362-07-2 | 100mg | $85 | 2026-04-30 | Buy |
| Cayman Chemical | 13021 | 2-Methoxyestradiol ≥95% | 362-07-2 | 5mg | $35 | 2026-04-30 | Buy |
2-Methoxyestradiol Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
A natural metabolite of 17Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a
Uses
A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly
Uses
2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.
Uses
2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.
Uses
2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.
Definition
ChEBI: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.
Biological Activity
Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.
in vivo
To investigate the effect of 2-Methoxyestradiol (2-ME2) on uveitis development, C57BL/6 mice are randomly assigned into two groups and immunized with IRBP peptide. 2ME2 group starts 2-Methoxyestradiol (15 mg/kg) intraperitoneally from day 0 to day 13 while control group is given with vehicle. The disease score of 2-Methoxyestradiol (2ME2) group is 0.30±0.30, significantly lower than that of control group 2.09±0.28 (p<0.05), each group containing 5 mice[3].
Treatment with 2-Methoxyestradiol (60-600 mg/kg/d) results in a dose-dependent inhibition of tumor growth. The percentage of cells with strong pimonidazole-positive staining (+++) is significantly decreased in the 2-Methoxyestradiol-treated group (36.0% for 60 mg/kg/d and 0% for 200 and 600 mg/kg/d) compare with the vehicle-treated group (86.5%). This may be attributed to the dramatic inhibition of tumor growth in a dose-dependent manner following 2-Methoxyestradiol treatment[4].
IC 50
Human Endogenous Metabolite
2-Methoxyestradiol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CHONGQING CHENCHENG PHARMACEUTICAL CO.，LTD. | 15310426561 | lf19823605252@163.com | China | 145 | 58 |
| Changsha Qisheng Heyan Medical Technology Co., LTD | 18684929597 | 527907673@qq.com | China | 127 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6746 | 52 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 |
View Lastest Price from 2-Methoxyestradiol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 2-Methoxyestradiol
362-07-2
|
1kg | 0.99 | 1000kg | Shaanxi Xianhe Biotech Co., Ltd | ||
 |
2026-01-19 | 2-Methoxyestradiol
362-07-2
|
1KG | 99% | 20 | CHONGQING CHENCHENG PHARMACEUTICAL CO.，LTD. | ||
 |
2025-12-25 | 2-Methoxyestradiol
362-07-2
|
1kg | 99% | 650KG | Wuhan Biocar Pharmacy CO.,Ltd. |
-
- 2-Methoxyestradiol
362-07-2
- $0.00
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
-
- 2-Methoxyestradiol
362-07-2
- 99%
- CHONGQING CHENCHENG PHARMACEUTICAL CO.，LTD.
-
- 2-Methoxyestradiol
362-07-2
- 99%
- Wuhan Biocar Pharmacy CO.,Ltd.
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