2-METHOXYESTRADIOL
- CAS No.
- 362-07-2
- Chemical Name:
- 2-METHOXYESTRADIOL
- Synonyms
- 2-Methoxy 17β-Estradiol;2-ME2;Panzem;2-MeOE2;NSC 659853;Methoxy estradiol;7-Methoxyestradiol;2-METHOXYESTRADIOL;2-METHOXYOESTRADIOL;2-Methoxy-β-estradiol
- CBNumber:
- CB5268052
- Molecular Formula:
- C19H26O3
- Molecular Weight:
- 302.41
- MDL Number:
- MFCD00010489
- MOL File:
- 362-07-2.mol
| Product description | Number | Pack Size | Price |
| 2-Methoxyestradiol | 454180 | 10mg | $98.6 |
| 2-Methoxyestradiol | 454180 | 50mg | $365 |
| 2-Methoxy-β-estradiol >97.0%(GC) | M2530 | 25mg | $40 |
| 2-Methoxy-β-estradiol >97.0%(GC) | M2530 | 100mg | $106 |
| 2-Methoxyestradiol ≥95% | 13021 | 5mg | $31 |
| More product size | |||
| Melting point | 188-190°C |
|---|---|
| Boiling point | 464.4±45.0 °C(Predicted) |
| Density | 1.178±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO: 10 mg/mL |
| pka | 10.29±0.60(Predicted) |
| form | crystalline |
| color | light yellow |
| λmax | 286nm(EtOH)(lit.) |
| InChI | InChI=1/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/s3 |
| InChIKey | CQOQDQWUFQDJMK-SSTWWWIQSA-N |
| SMILES | C[C@@]12[C@H](CC[C@@]1([H])[C@]1([H])CCC3C=C(O)C(OC)=CC=3[C@@]1([H])CC2)O |&1:1,2,5,7,20,r| |
| CAS DataBase Reference | 362-07-2(CAS DataBase Reference) |
| FDA UNII | 6I2QW73SR5 |
| NCI Dictionary of Cancer Terms | 2-methoxyestradiol |
| NCI Drug Dictionary | 2-methoxyestradiol |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331-H315-H319-H335-H350-H360-H372-H410 | |||||||||
| Precautionary statements | P273-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | T,Xi,N | |||||||||
| Risk Statements | 23/24/25-36/37/38-48-61-60-46-45-51/53 | |||||||||
| Safety Statements | 22-26-36/37/39-45-53-36-61 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KG7537500 | |||||||||
| HS Code | 2937.23.5050 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 Carc. 1B Eye Irrit. 2 Repr. 1B Skin Irrit. 2 STOT RE 1 STOT SE 3 |
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| NFPA 704 |
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2-METHOXYESTRADIOL price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 454180 | 2-Methoxyestradiol | 362-07-2 | 10mg | $98.6 | 2025-07-31 | Buy |
| Sigma-Aldrich | 454180 | 2-Methoxyestradiol | 362-07-2 | 50mg | $365 | 2025-07-31 | Buy |
| TCI Chemical | M2530 | 2-Methoxy-β-estradiol >97.0%(GC) | 362-07-2 | 25mg | $40 | 2025-07-31 | Buy |
| TCI Chemical | M2530 | 2-Methoxy-β-estradiol >97.0%(GC) | 362-07-2 | 100mg | $106 | 2025-07-31 | Buy |
| Cayman Chemical | 13021 | 2-Methoxyestradiol ≥95% | 362-07-2 | 5mg | $31 | 2024-03-01 | Buy |
2-METHOXYESTRADIOL Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
A natural metabolite of 17Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a
Uses
A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly
Uses
2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.
Uses
2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.
Uses
2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.
Definition
ChEBI: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.
Biological Activity
Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.
in vivo
To investigate the effect of 2-Methoxyestradiol (2-ME2) on uveitis development, C57BL/6 mice are randomly assigned into two groups and immunized with IRBP peptide. 2ME2 group starts 2-Methoxyestradiol (15 mg/kg) intraperitoneally from day 0 to day 13 while control group is given with vehicle. The disease score of 2-Methoxyestradiol (2ME2) group is 0.30±0.30, significantly lower than that of control group 2.09±0.28 (p<0.05), each group containing 5 mice[3].
Treatment with 2-Methoxyestradiol (60-600 mg/kg/d) results in a dose-dependent inhibition of tumor growth. The percentage of cells with strong pimonidazole-positive staining (+++) is significantly decreased in the 2-Methoxyestradiol-treated group (36.0% for 60 mg/kg/d and 0% for 200 and 600 mg/kg/d) compare with the vehicle-treated group (86.5%). This may be attributed to the dramatic inhibition of tumor growth in a dose-dependent manner following 2-Methoxyestradiol treatment[4].
IC 50
Human Endogenous Metabolite
2-METHOXYESTRADIOL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CHONGQING CHENCHENG PHARMACEUTICAL CO.，LTD. | 15923947264 | lf19823605252@163.com | China | 121 | 58 |
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 | Nancy@kangcang.com.cn | China | 341 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +86-17709210191; +8617709210191 | Jerry@xhobio.com | China | 870 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21596 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 | sean.lv@synzest.com | China | 323 | 58 |
| Hebei Runbin Biotechnology Co. LTD | 13180553332 | 2179877681@qq.com | CHINA | 990 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from 2-METHOXYESTRADIOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-25 | 2-Methoxyestradiol
362-07-2
|
US $0.00 / kg | 1kg | 0.99 | 1000kg | Shaanxi Xianhe Biotech Co., Ltd | |
 |
2026-01-19 | 2-Methoxyestradiol
362-07-2
|
US $0.00-0.00 / KG | 1KG | 99% | 20 | CHONGQING CHENCHENG PHARMACEUTICAL CO.，LTD. | |
 |
2025-12-25 | 2-Methoxyestradiol
362-07-2
|
US $0.00-0.00 / kg | 1kg | 99% | 650KG | Wuhan Biocar Pharmacy CO.,Ltd. |
-
- 2-Methoxyestradiol
362-07-2
- US $0.00 / kg
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
-
- 2-Methoxyestradiol
362-07-2
- US $0.00-0.00 / KG
- 99%
- CHONGQING CHENCHENG PHARMACEUTICAL CO.，LTD.
-
- 2-Methoxyestradiol
362-07-2
- US $0.00-0.00 / kg
- 99%
- Wuhan Biocar Pharmacy CO.,Ltd.
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