2-chloro-6-iodobenzoic acid
- CAS No.
- 13420-63-8
- Chemical Name:
- 2-chloro-6-iodobenzoic acid
- Synonyms
- 2-chloro-6-iodobenzoic acid;Benzoic acid, 2-chloro-6-iodo-
- CBNumber:
- CB22686064
- Molecular Formula:
- C7H4ClIO2
- Molecular Weight:
- 282.46
- MDL Number:
- MFCD06808823
- MOL File:
- 13420-63-8.mol
- MSDS File:
- SDS
| Melting point | 147-149℃ (heptane ethyl acetate ) |
|---|---|
| Boiling point | 333.6±27.0 °C(Predicted) |
| Density | 2.077±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| form | solid |
| pka | 1.63±0.10(Predicted) |
| Appearance | Yellow to brown Solid |
| InChI | 1S/C7H4ClIO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,(H,10,11) |
| InChIKey | KNWHWEKCHWFXFZ-UHFFFAOYSA-N |
| SMILES | OC(C1=C(Cl)C=CC=C1I)=O |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H319 |
| Precautionary statements | P301+P310+P330-P305+P351+P338 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| HazardClass | 6.1 |
| PackingGroup | Ⅲ |
| HS Code | 2916399090 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 |
2-chloro-6-iodobenzoic acid price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ALD00400 | 2-Chloro-6-iodobenzoic acid 95% | 13420-63-8 | 1g | $122 | 2026-04-30 | Buy |
| Biosynth | NAA42063 | 2-Chloro-6-iodobenzoic acid | 13420-63-8 | 0.25g | $250 | 2026-06-04 | Buy |
| Biosynth | NAA42063 | 2-Chloro-6-iodobenzoic acid | 13420-63-8 | 2.5g | $855.5 | 2026-06-04 | Buy |
| Apolloscientific | OR400966 | 2-Chloro-6-iodobenzoic acid 98% | 13420-63-8 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR400966 | 2-Chloro-6-iodobenzoic acid 98% | 13420-63-8 | 5g | $35 | 2026-06-04 | Buy |
2-chloro-6-iodobenzoic acid Chemical Properties, Uses, Production
Uses
The following building block was synthesized via a C-H activation method developed by Yu and coworkers. The method was incorporated using the Yu-Wasa Auxiliary (Aldrich 791806) and I2 as the sole oxidant for ortho-iodination from the corresponding benzoic acid derivative.
reaction suitability
reagent type: ligand
reaction type: C-H Activation
Synthesis
118-91-2
13420-63-8
General procedure: In a flame-dried 100 mL round-bottomed flask, 2-chlorobenzoic acid (16.4 mmol, 1.0 eq.), palladium acetate (0.05 eq.), iodobenzene diacetate (1.5 eq.), and iodine (1.5 eq.) were added and dissolved in anhydrous DMF (40 mL), and the reaction system was kept at atmospheric conditions. After sealing the flask with a rubber septum, the reaction mixture was stirred at 100 °C for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate and subsequently washed with 0.5 N HCl solution (420 mL). The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate and finally concentrated in a rotary evaporator. The crude product was purified by silica gel column chromatography (eluent ratio 3:1 hexane/ethyl acetate) to afford the target product 2-chloro-6-iodobenzoic acid.
References
[1] ACS Catalysis, 2018, vol. 8, # 2, p. 920 - 925
[2] Australian Journal of Chemistry, 2015, vol. 68, # 6, p. 912 - 918
[3] Angewandte Chemie - International Edition, 2008, vol. 47, # 28, p. 5215 - 5219
[4] Synthetic Communications, 2005, vol. 35, # 6, p. 799 - 806
2-chloro-6-iodobenzoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Tianjin Yao Technology Development Co., Ltd. | 022-18902014291 18902014291 | byswxsb01@163.com | China | 98 | 58 |
| Nanjing ShengSai Chemical Co., Ltd. | 025-85205967 13951876367 | shengsaichem@163.com | China | 818 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4534 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
View Latest Price from 2-chloro-6-iodobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-05 | 2-chloro-6-iodobenzoic acid
13420-63-8
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 2-chloro-6-iodobenzoic acid
13420-63-8
- $9.80
- ≥99%
- Career Henan Chemical Co
