ChemicalBook >> CAS DataBase List >>1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile structure

CAS No.: 517918-95-5

Chemical Name:: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile

Synonyms: 5-CYANO-7-AZAINDOLE;7-Azaindole-5-carbonitrile;7-Azaindole-5-carbonitrile,97%;5-canyo-1H-Pyrrolo[2,3-b]pyridine;5-Cyano-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile;1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile(9CI);1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE ISO 9001：2015 REACH;7-Azaindole-5-carbonitrile,1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile

CBNumber:: CB2271691

Molecular Formula:: C8H5N3

Molecular Weight:: 143.15

MDL Number:: MFCD06659684

MOL File:: 517918-95-5.mol

MSDS File:: SDS

Last updated:2026-09-12 18:50:36

Request For Quotation

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile Properties

Melting point	225.1-225.2°C
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	solid
pka	12.50±0.40(Predicted)
Appearance	Off-white to light brown Solid
InChI	InChI=1S/C8H5N3/c9-4-6-3-7-1-2-10-8(7)11-5-6/h1-3,5H,(H,10,11)
InChIKey	DRAQIXNADYAISI-UHFFFAOYSA-N
SMILES	C12NC=CC1=CC(C#N)=CN=2
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

NFPA 704

	1
2		0

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	ADE000896	1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile Aldrich	517918-95-5	1g	$870	2026-04-30	Buy
Apolloscientific	OR953815	1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile >97%	517918-95-5	250mg	$21	2026-06-04	Buy
Apolloscientific	OR953815	1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile >97%	517918-95-5	1g	$24	2026-06-04	Buy
Apolloscientific	OR953815	1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile >97%	517918-95-5	5g	$58	2026-06-04	Buy
Apolloscientific	OR953815	1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile >97%	517918-95-5	25g	$217	2026-06-04	Buy

Product number	Packaging	Price	Buy
ADE000896	1g	$870	Buy
OR953815	250mg	$21	Buy
OR953815	1g	$24	Buy
OR953815	5g	$58	Buy
OR953815	25g	$217	Buy

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile Chemical Properties, Uses, Production

Chemical Properties

Yellow fine crystalline powder

Uses

5-Cyano-7-azaindole is a commonly used intermediate in the synthesis of new anti-tumor drug protease inhibitors, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

557-21-1

183208-35-7

1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE

517918-95-5

1. 5-Bromo-1H-pyrrolo[2,3-b]pyridine (5.0 g, 25.0 mmol, 1.0 eq.) and zinc cyanide (3.6 g, 20.0 mmol, 0.8 eq.) were dissolved in anhydrous DMF (65 mL) and deoxygenated for 30 min under argon protection. 2. tetrakis(triphenylphosphine)palladium (1.7 g, 1.5 mmol, 0.06 eq.) was added and the reaction mixture was heated at 80 °C for 36 hours. 3. After completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate (EtOAc). 4. The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated to dryness under reduced pressure. 5. The residue was treated with a small amount of dichloromethane (CH2Cl2) and the precipitate was collected by filtration. 6. The precipitate was washed with dichloromethane and dried over air to give 1H-pyrrolo[2,3-b]pyridine-5-carbonitrile (Intermediate 2a) as a white solid (3.0 g; yield: 83%; UPLC purity: 100%).

References

[1] Patent: US2018/179199, 2018, A1. Location in patent: Paragraph 0451-0452
[2] Patent: WO2004/78756, 2004, A2. Location in patent: Page 120-121
[3] Patent: EP1782811, 2007, A1. Location in patent: Page/Page column 63
[4] Patent: WO2014/73904, 2014, A1. Location in patent: Paragraph 1425-1427

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile Preparation Products And Raw materials

Raw materials

Sodium cyanide ZINC CYANIDE 5-Bromo-7-azaindole Tetrakis(triphenylphosphine)palladium N,N-Dimethylformamide

Preparation Products

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile Suppliers

Global Suppliers ( 188)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Arbor Chemical Co., Ltd.	021-60451683 15021268886	sales@arborchemical.com	China	765	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Ark Pharm, Inc.	847-367-3680	sales@arkpharminc.com	United States	1669	56
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
Shanghai Arbor Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Ark Pharm, Inc.	56
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62
Shanghai Hanhong Scientific Co.,Ltd.	64

View Latest Price from 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE 517918-95-5	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-04-04	1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile 517918-95-5		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-12-26	1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE 517918-95-5	$1.00	1KG	99%	500kg	Career Henan Chemical Co

1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE
517918-95-5
$1.10
99.00%
Dideu Industries Group Limited

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile
517918-95-5
98%
Henan Aochuang Chemical Co.,Ltd.

1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE
517918-95-5
$1.00
99%
Career Henan Chemical Co

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile Spectrum

1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE(517918-95-5)¹HNMR

517918-95-5 (1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile) Related Search:

1H-Pyrrolo[3,2-b]pyridine-5-carbonitrile(9CI) 4-Cyano-7-azaindole 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 3-formyl- 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 6-bromo- 1H-Pyrrolo[2,3-c]pyridine-7-carbonitrile,4-methoxy-(9CI) 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 4-chloro-1-(phenylsulfonyl)- 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 3-bromo- 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 6-methyl-

1H-Pyrrolo[2,3-c]pyridine-7-carbonitrile,2,3-dihydro-5-methoxy-(9CI) 1H-Pyrrolo[3,2-c]pyridine-4-carbonitrile 3-Iodo-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile 3-Iodo-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile 1-Benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile 5-Cyano-6-methyl-7-azaindole 5-Chloro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile

1of4

1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile(9CI) 5-CYANO-7-AZAINDOLE 5-canyo-1H-Pyrrolo[2,3-b]pyridine 7-Azaindole-5-carbonitrile 7-Azaindole-5-carbonitrile,1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile 5-Cyano-1H-pyrrolo[2,3-b]pyridine 7-Azaindole-5-carbonitrile,97% 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE ISO 9001：2015 REACH 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile 517918-95-5 PYRIDINE Boron, Nitrile, Thio,& TM-Cpds Heterocycles Heterocycle-Pyridine series