Diethyl 2-fluoro-2-methyl-malonate
- CAS No.
- 16519-02-1
- Chemical Name:
- Diethyl 2-fluoro-2-methyl-malonate
- Synonyms
- 131916;Diethyl 2-fluoro-2-methyl-malonate;diethyl 2-fluoro-2-methylpropanedioate;2-fluoro-2-methylpropyldiacidiethyl ester;Propanedioic acid,2-fluoro-2-methyl-, 1,3-diethyl ester
- CBNumber:
- CB2274546
- Molecular Formula:
- C8H13FO4
- Molecular Weight:
- 192.18
- MDL Number:
- MFCD03844748
- MOL File:
- 16519-02-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501 |
| Risk Statements | 34-36/37/38 |
| Safety Statements | 26-36/37/39 |
| RIDADR | 1760 |
Diethyl 2-fluoro-2-methyl-malonate price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | D47071 | Diethyl 2-fluoro-2-methylmalonate 95+% | 16519-02-1 | 250mg | $61 | 2026-05-06 | Buy |
| Synthonix | D47071 | Diethyl 2-fluoro-2-methylmalonate 95+% | 16519-02-1 | 1g | $140 | 2026-05-06 | Buy |
| Synthonix | D47071 | Diethyl 2-fluoro-2-methylmalonate 95+% | 16519-02-1 | 5g | $410 | 2026-05-06 | Buy |
| Synthonix | D47071 | Diethyl 2-fluoro-2-methylmalonate 95+% | 16519-02-1 | 10g | $820 | 2026-05-06 | Buy |
| aablocks | AA001VX0 | Diethyl 2-fluoro-2-methylmalonate 95% | 16519-02-1 | 250mg | $45 | 2026-05-28 | Buy |
Diethyl 2-fluoro-2-methyl-malonate Chemical Properties, Uses, Production
Synthesis Reference(s)
Journal of the American Chemical Society, 109, p. 7194, 1987 DOI: 10.1021/ja00257a051
Synthesis
609-08-5
16519-02-1
In a test tube fitted with a stir bar, N-fluorobis(methylsulfonyl)imide (38.2 mg, 0.2 mmol) and 1,2-dichloroethane (1.0 mL) were added and stirred at room temperature until completely dissolved. Subsequently, diethyl 2-methylmalonate (17.4 mg, 0.1 mmol) and tetraisopropoxy prototitanate (0.016 mL, 0.05 mmol) were added to this solution and the reaction was carried out for 12 hours at room temperature. After completion of the reaction, water was added, extracted with dichloromethane (3 times), the organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was analyzed by 19F-NMR and the yield of the target product diethyl 2-fluoro-2-methylmalonate was quantified using hexafluorobenzene as an internal standard. Finally, the product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane = 10/90, v/v) to afford the purified diethyl 2-fluoro-2-methylmalonate (7) as a colorless and transparent liquid (18.7 mg, 0.097 mmol, 97% yield).
References
[1] Patent: JP2016/23178, 2016, A. Location in patent: Paragraph 0031-0033
[2] Green Chemistry, 2016, vol. 18, # 7, p. 1864 - 1868
[3] Patent: WO2017/49069, 2017, A1. Location in patent: Paragraph 00160
[4] Journal of the American Chemical Society, 1984, vol. 106, # 2, p. 452 - 454
[5] Canadian Journal of Chemistry, 1965, vol. 43, p. 1700 - 1713
Diethyl 2-fluoro-2-methyl-malonate Preparation Products And Raw materials
Raw materials
Preparation Products
Diethyl 2-fluoro-2-methyl-malonate Suppliers
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