2,3,4,9-Tetrahydro-1H-beta-carboline-3-carboxylic acid
- CAS No.
- 6052-68-2
- Chemical Name:
- 2,3,4,9-Tetrahydro-1H-beta-carboline-3-carboxylic acid
- Synonyms
- 2,3,4,9-Tetrahydro-1H-β-carboline-3-carboxylic acid;1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid;2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid;H-TPI-OH;1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylic acid;DL-Tpi-OH;AKOS BC-1280;AKOS BBS-00007515;Tryptophan Impurity H;Tryptophan Impurity 8
- CBNumber:
- CB2283522
- Molecular Formula:
- C12H12N2O2
- Molecular Weight:
- 216.24
- MDL Number:
- MFCD00204332
- MOL File:
- 6052-68-2.mol
- MSDS File:
- SDS
| Melting point | 289 °C (dec.)(lit.) |
|---|---|
| Boiling point | 485.0±45.0 °C(Predicted) |
| Density | 1.377±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 2.28±0.20(Predicted) |
| Appearance | Light brown to brown Solid |
| InChI | InChI=1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16) |
| InChIKey | FSNCEEGOMTYXKY-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2)C2CC(C(O)=O)NCC1=2 |
| FDA UNII | CK2W5X3J2K |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H226 | |||||||||
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
2,3,4,9-Tetrahydro-1H-beta-carboline-3-carboxylic acid price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S277886 | 2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-3-CARBOXYLIC ACID AldrichCPR | 6052-68-2 | 1 unit | $121 | 2026-04-30 | Buy |
| Sigma-Aldrich | S277886 | 2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-3-CARBOXYLIC ACID AldrichCPR | 6052-68-2 | 10MG | $110 | 2024-03-01 | Buy |
| Biosynth | GAA05268 | 2,3,4,9-Tetrahydro-1H-pyrido[3,4-β]indole-3-carboxylic acid | 6052-68-2 | 10g | $472 | 2026-06-04 | Buy |
| Synthonix | T60868 | 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid >98% | 6052-68-2 | 1g | $88 | 2026-05-06 | Buy |
| Synthonix | T60868 | 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid >98% | 6052-68-2 | 5g | $100 | 2026-05-06 | Buy |
2,3,4,9-Tetrahydro-1H-beta-carboline-3-carboxylic acid Chemical Properties,Uses,Production
Definition
ChEBI: A member of the class of beta-carbolines that is 1,2,3,4-tetrahydro-beta-carboline substituted at position 3 by a carboxy group.
Synthesis
50-00-0
73-22-3
6052-68-2
The general procedure for the synthesis of 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid from formaldehyde and L-tryptophan was as follows: first, 1-propanesulfonic acid (817 mg, 4 mmol) was mixed with 2.5 M NaOH solution (1.6 mL), and the mixture was stirred at room temperature until it became clear. Subsequently, 37% formalin (4.87 mL) was added to the mixture. The reaction mixture was stirred at room temperature for 2 hours and then refluxed for 3 hours. Upon completion of the reaction, it was neutralized with 2 M HCl solution to pH 5. The precipitate precipitated was filtered, washed sequentially with water and methanol and finally dried under vacuum to afford the target product 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid. The yield of this step was 99% and the product was a colorless solid with a melting point of 302.2-304.6 °C. Mass spectrometry (FAB) analysis showed m/z 217 (M+1, 100%).
References
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 2, p. 636 - 646
[2] Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1994, vol. 48, # 5, p. 434 - 438
[3] Patent: CN106432235, 2017, A. Location in patent: Paragraph 0217; 0218
[4] Patent: US2013/178629, 2013, A1. Location in patent: Paragraph 0109
[5] Molecules, 2010, vol. 15, # 11, p. 7775 - 7791
2,3,4,9-Tetrahydro-1H-beta-carboline-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Acme Chemical Co., Ltd. | 0371-0371-55629727 13323845623 | 2885676761@qq.com | China | 9948 | 58 |
| Shanghai HC Biotech Co., Ltd | 021-20227858 | sale@hcbiotech.com.cn | China | 1173 | 55 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shanghai Tombiopharma Chemical Co. Ltd. | 13391076197 | tombiopharma@163.com | China | 4986 | 55 |
| Zhengzhou Gecko Scientific Inc. | 0371-63336364 17344886665 | 209932355@qq.com | China | 535 | 55 |
| Shenzhen Chim Biotech Co., Ltd. | 13692196024 | sales@chimchem.com | China | 500 | 55 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9609 | 60 |
View Lastest Price from 2,3,4,9-Tetrahydro-1H-beta-carboline-3-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-3-CARBOXYLIC ACID
6052-68-2
|
$1.00 | 1KG | 97% | 200KG | Career Henan Chemical Co |
-
- 2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-3-CARBOXYLIC ACID
6052-68-2
- $1.00
- 97%
- Career Henan Chemical Co
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