7-Chloro-1-hydroxyisoquinoline
- CAS No.
- 24188-74-7
- Chemical Name:
- 7-Chloro-1-hydroxyisoquinoline
- Synonyms
- 7-Chloroisoquinolin-1-ol;7-CHLORO-1(2H)-ISOQUINOLONE;7-Chloro-1(2H)-isoquinolinone;7-chloro-2H-isoquinolin-1-one;7-Chloro-1-hydroxyisoquinoline;1(2H)-Isoquinolinone, 7-chloro-;7-chloro-1,2-dihydroisoquinolin-1-one
- CBNumber:
- CB2284392
- Molecular Formula:
- C9H6ClNO
- Molecular Weight:
- 179.6
- MDL Number:
- MFCD08436984
- MOL File:
- 24188-74-7.mol
- MSDS File:
- SDS
| Melting point | 245-247 °C(Solv: methanol (67-56-1)) |
|---|---|
| Boiling point | 414.9±45.0 °C(Predicted) |
| Density | 1.339±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 11.99±0.20(Predicted) |
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C9H6ClNO/c10-7-2-1-6-3-4-11-9(12)8(6)5-7/h1-5H,(H,11,12) |
| InChIKey | YWUCOQGBXQHOJM-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=CC(Cl)=C2)C=CN1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| HS Code | 2933499090 |
| REACH Registrations | Inactive |
7-Chloro-1-hydroxyisoquinoline price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 439607 | 7-Chloroisoquinolin-1(2H)-one | 24188-74-7 | 250mg | $375 | 2026-06-03 | Buy |
| Usbiological | 439607 | 7-Chloroisoquinolin-1(2H)-one | 24188-74-7 | 1g | $623 | 2026-06-03 | Buy |
| Biosynth | ZAA18874 | 7-Chloroisoquinolin-1-ol | 24188-74-7 | 5g | $472 | 2026-06-05 | Buy |
| Apolloscientific | OR300118 | 7-Chloroisoquinolin-1-ol ≥95% | 24188-74-7 | 250mg | $41 | 2026-06-04 | Buy |
| Apolloscientific | OR300118 | 7-Chloroisoquinolin-1-ol ≥95% | 24188-74-7 | 1g | $122 | 2026-06-04 | Buy |
7-Chloro-1-hydroxyisoquinoline Chemical Properties,Uses,Production
Uses
7-Chloroisoquinolin-1(2H)-one acts as a reagent for the preparation, SAR of methoxyisoquinoline derivative and discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection. Synthesis and pharmacological evaluation of a series of 1,2-dihydro-1-[(5-methyl-1-imidazol-4-yl)methyl]-2-oxopyridine 5-HT3 antagonists.
Synthesis
1615-02-7
26386-88-9
24188-74-7
Step 1: Diphenyl phosphate azide (DPPA, 27.5 g, 0.1 mol) was added dropwise to a solution of (E)-3-(4-chlorophenyl)acrylic acid (18.3 g, 0.1 mol) and triethylamine (Et3N, 20.2 g, 0.2 mol) in benzene (100 mL). After stirring the reaction mixture for 2 h, the solution was concentrated and purified by fast chromatography (Biotage system, mobile phase 20/80 ethyl acetate/hexane) to give 16 g of the intermediate azide as a solid. The intermediate was dissolved in 100 mL of 1,2-dichloroethane and the resulting mixture was slowly heated to 90 °C over 30 min. The reaction mixture was then heated to reflux and held at this temperature for 3 hours. After cooling to room temperature, a solid was precipitated, collected by filtration and washed with toluene to give 9.5 g of 7-chloroisoquinolin-1(2H)-one in 53% yield. Product characterization data. 1H NMR (400 MHz, CD3OD) δ ppm: 6.66 (d, J = 7.05 Hz, 1H), 7.18 (d, J = 7.05 Hz, 1H), 7.66 (s, 1H), 7.67 (d, J = 2.01 Hz, 1H), 8.24 (d, J = 2.27 Hz, 1H). 13C NMR (101 MHz, DMSO-D6) δ ppm: 104.05, 125.62, 127.21, 128.54, 129.52, 130.77, 132.43, 136.55, 160.72. LC/MS, MS m/z (M + H)+: 180.
References
[1] Patent: WO2012/166459, 2012, A1. Location in patent: Page/Page column 23-24
7-Chloro-1-hydroxyisoquinoline Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Suifu Chemical Technology CO.,LTD. | 33738187 19945655289 | suifuchemical@163.com | China | 500 | 58 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai ChriChem Co., Ltd. | 021-54880687 | China | 510 | 55 | |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1784 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4545 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Bellen Chemistry Co., Ltd. | 010-60400365-8001 15910885229 | service@bellenchem.com | China | 4514 | 60 |
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