5-Formyl-2-methoxy-4-picoline
- CAS No.
- 123506-66-1
- Chemical Name:
- 5-Formyl-2-methoxy-4-picoline
- Synonyms
- CML-015;5-Formyl-2-methoxy-4-picoline;2-Fluoro-37-(methylthio)pyridine;6-methoxy-4-methylnicotinaldehyde;6-Methoxy-4-methyl-3-pyridinecarboxaldehyde;3-Pyridinecarboxaldehyde, 6-methoxy-4-methyl-;3-Pyridinecarboxaldehyde, 6-methoxy-4-methyl- (9CI)
- CBNumber:
- CB2284615
- Molecular Formula:
- C8H9NO2
- Molecular Weight:
- 151.16
- MDL Number:
- MFCD07368879
- MOL File:
- 123506-66-1.mol
- MSDS File:
- SDS
5-Formyl-2-methoxy-4-picoline price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | YEA50666 | 5-Formyl-2-methoxy-4-picoline | 123506-66-1 | 5g | $413 | 2026-06-05 | Buy |
| ACHEMBLOCK | Q66658 | 6-methoxy-4-methylnicotinaldehyde 97% | 123506-66-1 | 25G | $270 | 2026-05-27 | Buy |
| Crysdot | CD11319793 | 6-Methoxy-4-methylnicotinaldehyde 95% | 123506-66-1 | 5g | $594 | 2026-05-27 | Buy |
| AOBChem | A14129 | 5-Formyl-2-methoxy-4-picoline ≥97% | 123506-66-1 | 500mg | $30 | 2026-05-26 | Buy |
| AOBChem | A14129 | 5-Formyl-2-methoxy-4-picoline ≥97% | 123506-66-1 | 1g | $42 | 2026-05-26 | Buy |
5-Formyl-2-methoxy-4-picoline Chemical Properties,Uses,Production
Synthesis
68-12-2
164513-39-7
123506-66-1
General procedure for the synthesis of 5-formyl-2-methoxy-4-methyl-4-methylpyridine from 2-methoxy-4-methyl-5-bromopyridine and N,N-dimethylformamide: 5-bromo-2-methoxy-4-methylpyridine (2.6 g, 13 mmol) was dissolved in anhydrous THF (40 mL) and cooled to -70 °C under argon protection. A hexane solution of 1.6 M n-butyllithium (8.1 mL, 14 mmol) was slowly added over 10 min with stirring. The reaction temperature was maintained at -70 °C and stirring was continued for 30 min. Subsequently, anhydrous DMF (1.2 mL, 15 mmol) was added in batches, keeping the temperature constant. After addition, stirring was continued at -70 °C for 30 min, then brought to room temperature and stirred overnight. Upon completion of the reaction, the reaction was quenched with 1 M hydrochloric acid (40 mL) and subsequently extracted three times with tert-butyl methyl ether (TBME). The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. Purification by column chromatography using tert-butyl methyl ether-light petroleum ether (1:1) as eluent afforded 1.8 g (91% yield) of 5-formyl-2-methoxy-4-methylpyridine as a light yellow solid.LC-MS m/z 152 (M + 1); 1H NMR (CDCl3) δ 10.1 (s, 1H), 8.55 (s, 1H), 6.61 ( s, 1H), 4.05 (s, 3H), 2.60 (s, 3H) ppm.
References
[1] Patent: WO2006/65215, 2006, A1. Location in patent: Page/Page column 19; 35
[2] Synthetic Communications, 2009, vol. 39, # 17, p. 3060 - 3068
[3] Patent: WO2015/158427, 2015, A1. Location in patent: Page/Page column 84; 85
5-Formyl-2-methoxy-4-picoline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7882 | 64 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Anichem Inc. | 0512-69369885 | sales@anichem.com.cn | China | 493 | 55 |
| Shanghai Hong-chuang Pharma Tech Co., Ltd. | 18151128828 | hc-sales@foxmail.com | China | 2635 | 55 |
| Porse Fine Chemical Co.,LTD | 20-66003216 18666003216 | info@porsefinechemical.com | China | 1964 | 62 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Hangzhou Milestone Pharmtech Co., Ltd. | 0571-82896630 18969958410 | sales_hz@milestonepharmtech.com | China | 4906 | 55 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4975 | 55 |
| Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. | 027-65388397 18164111589 | 3321478047@qq.com | China | 2002 | 55 |
| ShangHai Siyan Biological Technology Co., Ltd. | 021-50908862，442785678，326799392 18721037013 | siyansales@126.com | China | 9612 | 58 |
View Lastest Price from 5-Formyl-2-methoxy-4-picoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-24 | 5-Formyl-2-methoxy-4-picoline
123506-66-1
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2020-01-14 | 5-FORMYL-2-METHOXY-4-PICOLINE
123506-66-1
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 5-Formyl-2-methoxy-4-picoline
123506-66-1
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-FORMYL-2-METHOXY-4-PICOLINE
123506-66-1
- $9.80
- ≥99%
- Career Henan Chemical Co
