alpha-Hydroxyalprazolam
- CAS No.
- 37115-43-8
- Chemical Name:
- alpha-Hydroxyalprazolam
- Synonyms
- 8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-1-methanol;α-Hydroxyalprazolam;A-HYDROXYALPRAZOLAM;α-hydroxy Alprazolam;Piraxostat Impurity 27;alpha-Hydroxyalprazolam;-hydroxy Alprazolam (CRM);α-hydroxy Alprazolam (CRM);alpha-Hydroxyalprazolam solution;α-hydroxyalprazolam Solution, 100ppm
- CBNumber:
- CB2313681
- Molecular Formula:
- C17H13ClN4O
- Molecular Weight:
- 324.76
- MDL Number:
- MFCD00171226
- MOL File:
- 37115-43-8.mol
- MSDS File:
- SDS
| Melting point | 129-134°C |
|---|---|
| Flash point | 9℃ |
| storage temp. | -20°C Freezer |
| solubility | methylene chloride: ~20 mg/mL, clear, colorless to faintly yellow |
| form | powder |
| color | white to off-white |
| Major Application | clinical testing |
| InChI | 1S/C17H13ClN4O/c18-12-6-7-14-13(8-12)17(11-4-2-1-3-5-11)19-9-15-20-21-16(10-23)22(14)15/h1-8,23H,9-10H2 |
| InChIKey | ZURUZYHEEMDQBU-UHFFFAOYSA-N |
| SMILES | OCc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4-n12 |
| FDA UNII | V7J2Z5Y50U |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| target organs | Eyes,Central nervous system | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 20/21/22-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 36-45-36/37-16-7 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1 |
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| NFPA 704 |
|
alpha-Hydroxyalprazolam price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A-907 | alpha-Hydroxyalprazolam solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 37115-43-8 | 1mL | $118 | 2026-04-30 | Buy |
| Cayman Chemical | 25517 | α-hydroxy Alprazolam (CRM) | 37115-43-8 | 1mg | $87 | 2026-04-30 | Buy |
| Cayman Chemical | 15287 | α-hydroxy Alprazolam ≥98% | 37115-43-8 | 1mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 15287 | α-hydroxy Alprazolam ≥98% | 37115-43-8 | 5mg | $391 | 2026-04-30 | Buy |
| ChemScene | CS-0068299 | α-Hydroxy alprazolam 98% | 37115-43-8 | 1mg | $282 | 2026-06-04 | Buy |
alpha-Hydroxyalprazolam Chemical Properties, Uses, Production
Description
α-hydroxy Alprazolam (Item No. 15287) is an analytical reference material categorized as a benzodiazepine. It is a major active metabolite of alprazolam (CRM) that has a higher urinary recovery than 4-hydroxy alprazolam , another major metabolite. α-hydroxy Alprazolam has a lower binding affinity than alprazolam for the GABAA receptor. It is also a metabolite of adinazolam . This product is intended for research and forensic applications.
Chemical Properties
Yellow solid
Uses
A metabolite of Alprazolam, an anxiolytic
Definition
ChEBI: Alpha-Hydroxyalprazolam is a triazolobenzodiazepine.
General Description
A major urinary metabolite of the benzodiazepine alprazolam. Alprazolam, commonly sold under the trade name Xanax, is a short-acting anxiolytic approved to treat panic and other anxiety disorders including generalized or social anxiety disorder. This certified Snap-N-Spike solution standard is suitable for use in LC/MS or GC/MS applications such as forensic analysis, clinical toxicology, urine drug testing, or pain prescription monitoring.
References
[1] D J GREENBLATT C E W. Clinical pharmacokinetics of alprazolam. Therapeutic implications.[J]. Clinical Pharmacokinetics, 1993, 24 6: 453-471. DOI: 10.2165/00003088-199324060-00003
[2] MIOK SHIN. Screening of multiple drugs of abuse and metabolites in urine using LC/MS/MS with polarity switching electrospray ionization[J]. Archives of Pharmacal Research, 2013, 37 6: 760-772. DOI: 10.1007/s12272-013-0225-0
[3] ANNIKA ALLQVIST. Simultaneous quantification of alprazolam, 4- and α-hydroxyalprazolam in plasma samples using liquid chromatography mass spectrometry[J]. Journal of Chromatography B, 2005, 814 1: Pages 127-131. DOI: 10.1016/j.jchromb.2004.10.012
[4] A D FRASER W B A F Isner. Urinary screening for adinazolam and its major metabolites by the Emit d.a.u. and FPIA benzodiazepine assays with confirmation by HPLC.[J]. Journal of analytical toxicology, 1993, 17 7: 427-431. DOI: 10.1093/jat/17.7.427
alpha-Hydroxyalprazolam Preparation Products And Raw materials
Raw materials
Preparation Products
alpha-Hydroxyalprazolam Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | offer.de@lgcgroup.com | China | 19036 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12577 | 58 |
| Shanghai Weiyite Biotechnology Co., Ltd | 15317051735 | zhaojing@wytsci.com | China | 10000 | 58 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
