ANTISAUVAGINE-30
- CAS No.
- 220673-95-0
- Chemical Name:
- ANTISAUVAGINE-30
- Synonyms
- ANTISAUVAGINE-30;PubChem ID: 90471086;M.W. 3650.29 C161H274N48O46S;(D-Phe??,His??)-Sauvagine (11-40);(D-PHE11,HIS12)-SAUVAGINE (11-40);11-D-Phenylalanine-12-L-histidine-11-40-sauvagin;(D-PHE11,HIS12)-SAUVAGINE (11-40) TRIFLUOROACETATE SALT;D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2;H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THE-ILE-OH;H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2
- CBNumber:
- CB2314057
- Molecular Formula:
- C161H273N47O47S
- Molecular Weight:
- 3651.24
- MDL Number:
- MFCD04115623
- MOL File:
- 220673-95-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
ANTISAUVAGINE-30 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FP109630 | (D-Phe11,His12)-Sauvagine (11-40) trifluoroacetate salt | 220673-95-0 | 500ug | $900 | 2026-06-04 | Buy |
| Biosynth | FP109630 | (D-Phe11,His12)-Sauvagine (11-40) trifluoroacetate salt | 220673-95-0 | 1000ug | $900 | 2026-06-04 | Buy |
| Biosynth | FP109630 | (D-Phe11,His12)-Sauvagine (11-40) trifluoroacetate salt | 220673-95-0 | 250ug | $900 | 2026-06-04 | Buy |
| Biosynth | FP109630 | (D-Phe11,His12)-Sauvagine (11-40) trifluoroacetate salt | 220673-95-0 | 2000ug | $1520 | 2026-06-04 | Buy |
| Biosynth | FP109630 | (D-Phe11,His12)-Sauvagine (11-40) trifluoroacetate salt | 220673-95-0 | 5000ug | $3250 | 2026-06-04 | Buy |
ANTISAUVAGINE-30 Chemical Properties, Uses, Production
Uses
Antisauvagine-30 (aSvg-30) is a potent, competitive and selective CRF2 receptor antagonist with Kd values of 1.4 nM and 153.6 nM for mouse CRF2βand rat CRF1receptors, respectively[1].
Enzyme inhibitor
This highly selective CRF2 antagonist (MW = 3650.29 g/mol; CAS 220673-95-0; Sequence: D-Phe-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile- Glu-Lys-Gln-Glu-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2; Solubility: 5 mg/mL H2O; Alternate Name: [D-Phe 11 ,His 12 ]-Sauvagine (11- 40)) targets human Corticotropin-Releasing hormone (CRH) Receptor-2 subtypes CRF2β (Ki = 1.4 nM), with a much higher value of 154 nM for CRF1. (See also Astressin; K41448) Type-2 GPCRs reside in plasma membranes of hormone-sensitive cells and bind CRH, a peptide hormone and neurotransmitter involved in stress responses. Antisauvagine-30 blocks (pA2 = 8.49) sauvagine-stimulated accumulation of cAMP in HEK-mCRF2β cells. It also prevents stress-enhanced fear conditioning and MEK1/2- dependent activation of ERK1/2 in mice and suggesting a role for protein kinase signaling in the hippocampus and its modulation by CRF2 as a possible link between stress and fear memory.
References
[1] O Brauns, et al. Pharmacological and chemical properties of astressin, antisauvagine-30 and alpha-helCRF: significance for behavioral experiments. Neuropharmacology. 2001 Sep;41(4):507-16. DOI:10.1016/s0028-3908(01)00094-6
[2] Farahnaz Sananbenesi, et al. Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory. J Neurosci DOI:10.1523/JNEUROSCI.23-36-11436.2003
ANTISAUVAGINE-30 Preparation Products And Raw materials
Raw materials
Preparation Products
ANTISAUVAGINE-30 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1010 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4725 | 58 |
