Phenibut

Phenibut Properties

Melting point	252.5°C (rough estimate)
Boiling point	311.75°C (rough estimate)
Density	1.1248 (rough estimate)
refractive index	1.5710 (estimate)
solubility	Free base: 35 mg/mL in DMSO (195.29 mM) at 25 °C (SellekChem, 2019).Hydrochloride salt (Cayman, 2016): 25 mg/ml in DMF; 20 mg/ml in DMSO; 14 mg/ml in ethanol; 10 mg/mL in PBS (pH 7.2).
pka	4.10±0.10(Predicted)
form	solid
color	White
InChI	InChI=1S/C10H13NO2/c11-7-9(6-10(12)13)8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13)
InChIKey	DAFOCGYVTAOKAJ-UHFFFAOYSA-N
SMILES	C(O)(=O)CC(C1=CC=CC=C1)CN
CAS DataBase Reference	1078-21-3(CAS DataBase Reference)
FDA UNII	T2M58D6LA8
EPA Substance Registry System	Benzenepropanoic acid, .beta.-(aminomethyl)- (1078-21-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P280-P302+P352-P305+P351+P338
Hazard Codes	Xi
TSCA	TSCA listed
HazardClass	IRRITANT
HS Code	2922498590
Toxicity	TDLo orl-hmn: 5 mg/kg:CNS BEXBAN 57,52,64

Phenibut price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	P2974	Phenibut	1078-21-3	5G	$63	2026-04-30	Buy
TCI Chemical	P2974	Phenibut	1078-21-3	25G	$221	2026-04-30	Buy
Cayman Chemical	43389	Phenibut (CRM)	1078-21-3	1mg	$126	2026-04-30	Buy
Biosynth	FA130469	4-Amino-3-phenylbutanoic acid	1078-21-3	5g	$162.25	2026-06-04	Buy
Biosynth	FA130469	4-Amino-3-phenylbutanoic acid	1078-21-3	10g	$259.6	2026-06-04	Buy

Product number	Packaging	Price	Buy
P2974	5G	$63	Buy
P2974	25G	$221	Buy
43389	1mg	$126	Buy
FA130469	5g	$162.25	Buy
FA130469	10g	$259.6	Buy

Phenibut Chemical Properties, Uses, Production

Description

Phenibut, also known as fenibut, phenigamma, and beta-phenyl-gamma-aminobutyric acid, is a derivative of the neurotransmitter GABA. It was developed in Russia,and there it has been used clinically since the 1960s to treat anxiety and related conditions，including insomnia(Lapin，2001). Phenibut has anxiolytic properties and is commonlycompared to benzodiazepines and baclofen.Structurally，phenibut issimilar to GABA, with the addition of the phenyl ring. This allows thecompound to more easily cross the blood-brain barrier, but also changesits activity profile (Shulgina,1986). Scientific studies demonstrate that phenibut can be safely used to treat anxiety, depression,epilepsy, speech disorders, and insomnia.

Uses

4-amino-3-phenylbutanoic acid (cas# 1078-21-3) is a GABAA receptor agonist, used for treatment of disorders influenced by dysfunction of pancreatic β cells and also used in combination with other agents.

Preparation

Phenibut was synthesized by Perekalin and his associates at the Department of Organic Chemistry of the Herzen Pedagogic Institute in St. Petersburg, the Russian Federation. In initial publications phenibut was known as phenigamma (Lapin, 2001, V. V. Perekalin, 1954).
Fenibut synthesis: from benzoyl chloride and ethyl acetoacetate as raw materials, through condensation and hydrolysis of ethyl benzoyl acetate, and then condensation of benzaldehyde and nitromethane to generate trans-nitrostyrene, and then the two are combined. Micheal addition, the adduct is then catalytically hydrogenated with Raney nickel, and finally hydrolyzed in concentrated hydrochloric acid to produce phenibate.

Synthesis of Phenibut (16) and Baclofen (17).

Application

Phenibut is an anxiolytic and nootropic drug, discovered in the Soviet Union used to treat several psychiatric disorders. It can be used in the treatment of anxiety, depression, asthenia, post-traumatic stress disorder, stuttering, and vestibular disorders.

Definition

ChEBI: Phenibut is an organonitrogen compound and an organooxygen compound. It is functionally related to a gamma-amino acid.

Side effects

When taken by mouth: Phenibut is likely unsafe. Phenibut can cause many side effects, including reduced consciousness, dizziness, nausea, poor balance, and fatigue. Taking large doses can cause trouble breathing, unconsciousness, and death.
Phenibut can cause dependence. People who use phenibut for 3 days or more and then stop taking it might experience withdrawal symptoms. These symptoms can include decreased appetite, nausea, muscle aches, fast heart rate, anxiety, agitation, trouble sleeping, and seizures.

Safety Profile

Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: somnolence, hallucinations, distorted perception. Used as a mood elevator and tranquilizer. When heated to decomposition it emits toxic fumes of NOx.

Drug interactions

Pregabalin (Lyrica) interacts with Phenibut: Phenibut acts on the brain in a similar way to pregabalin. Taking these two chemicals together might increase the risk for side effects.
Sedative medications (CNS depressants) interacts with Phenibut: Phenibut might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking phenibut with sedative medications might cause breathing problems and/or too much sleepiness.

Regulatory Status

USA - Phenibut is still an uncontrolled substance in the United States, and it is legal to sell and possess phenibut. It has not been approved for clinical use in the United States.
Europe - Unscheduled. It is not regulated by the European Medicines Agency. However, some nootropic substances such as piracetam are available only on prescription in some European Union countries and are freely available in others.
Russia - Phenibut is a licensed prescription medication used for a variety of conditions including anxiety, insomnia, post-traumatic stress disorders, depression, stuttering, tics, attention deficit disorders, and vestibular disorders. Russian cosmonauts were reported to have been supplied with the substance to help relieve tension, anxiety and fear (Buckley 2006).

Phenibut synthesis

Synthesis of Phenibut from 4-Phenyl-2-pyrrolidinone

Phenibut Preparation Products And Raw materials

Raw materials

Preparation Products

Phenibut Suppliers

Global Suppliers ( 382)

Supplier	Tel	Email	Country	ProdList	Advantage
Xi'an Lyna Bio-Tech Co., Ltd.	13193362370	mia@lynabio.com	China	741	55
Shanghai Norky Pharmaceutical Co., Ltd.	021-021-61075308 15216782696	sales@norkysh.com	China	65	58
Wuhan Senwayer Century Chemical Co.,Ltd	027-86652399	sales@senwayer.com	China	266	55
HANGZHOU LOOP BIOTECH CO., LTD.	057185260761 13396556070	sales@looppharm.com	China	56	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62

Supplier	Advantage
Xi'an Lyna Bio-Tech Co., Ltd.	55
Shanghai Norky Pharmaceutical Co., Ltd.	58
Wuhan Senwayer Century Chemical Co.,Ltd	55
HANGZHOU LOOP BIOTECH CO., LTD.	58
J & K SCIENTIFIC LTD.	76
INTATRADE GmbH	66
TAIYUAN RHF CO.,LTD.	56
ShangHai DEMO Chemical Co.,Ltd	57
Wuhan Chemwish Technology Co., Ltd	56
Pure Chemistry Scientific Inc.	62

View Latest Price from Phenibut manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	Phenibut 1078-21-3	$1.00		99%	200KG	Jinan Million Pharmaceutical Co., Ltd
2026-09-18	Phenibut 1078-21-3	$2.50	1kg	99.32	60 tons	Jinan Million Pharmaceutical Co., Ltd
2026-09-18	4-Amino-3-phenylbutanoic acid 1078-21-3	$10.00	1ASSAYS	99%	100kg	RongNa Biotechnology Co.,Ltd

Phenibut
1078-21-3
$1.00
99%
Jinan Million Pharmaceutical Co., Ltd

Phenibut
1078-21-3
$2.50
99.32
Jinan Million Pharmaceutical Co., Ltd

4-Amino-3-phenylbutanoic acid
1078-21-3
$10.00
99%
RongNa Biotechnology Co.,Ltd

Phenibut Spectrum

Phenibut(1078-21-3)¹HNMR

1078-21-3 (Phenibut) Related Search:

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(R)-3-Amino-4-phenylbutyric acid hydrochloride L-beta-Homophenylalanine hydrochloride L-Homophenylalanine hydrochloride Baclofen (R)-Baclofen

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-Amino-3-phenylbutyric acid hydrochloride NA###4-Amino-3-phenylbutyric acid hydrochloride PHENIBUTCAS NO.: 1078-21-3 Phenibut CAS NO.1078-21-3 Nootropics Powder Nutrition Supplement Phenibut for Fatigue Reduce CAS 1078-21-3 TIMTEC-BB SBB001567 fenigama pgaba phenigam phenigama phenylgam phenylgamma FENIBUT Phenibut 4-Amino-3-Phenylbutyric Acid 4-Amino-3-phenylbutanoic acid Hydrochloride, Phenibut AMINOBUTYRIC ACID, beta-PHENYL-gaMMa-(P) Phenybut Phenygam 4-azanyl-3-phenyl-butanoic acid (4-hydroxy-4-keto-2-phenyl-butyl)ammonium chloride (4-hydroxy-4-oxo-2-phenylbutyl)ammonium chloride (4-hydroxy-4-oxo-2-phenyl-butyl)ammonium chloride (4-hydroxy-4-oxo-2-phenylbutyl)azanium chloride (4-hydroxy-4-oxo-2-phenyl-butyl)azanium chloride HYDROCINNAMIC ACID, beta-(AMINOMETHYL)-, HYDROCHLORIDE 4-amino-3-phenylbutanoicacid 4-amino-3-phenyl-butyricaci beta-(aminomethyl)-benzenepropanoicaci beta-(aminomethyl)benzenepropanoicacid beta-(aminomethyl)hydrocinnamicacid beta-phenyl-gamma-aminobutyrate beta-phenyl-gamma-aminobutyricacid fenigam 4-AMINO-3-PHENYL-BUTYRIC ACID 4-AMINO-3-PHENYL BUTYRIC ACID HYDROCHLORIDE 4-Amino-3-pheny-butyric acid 4-Amino-3-phenyl 4-AMINO-3-PHENY-BUTYRICACIDHYDROCHLORIDE PHENYLBUT (4-AMINO-3-PHENYLBUTYRIC ACID HCL) 3-PHENYL-4-AMINOBUTYRICACIDHCL 4-Amino-3-phenylbutyric acid hydrchloride B-(Aminomethyl)-benzenepropionic acid hydrochloride Phenibut (4-AMino-3-phenylbutyric acid HCl) Benzenepropanoic acid, b-(aMinoMethyl)- Benzenepropanoic acid, .beta.-(aminomethyl)- PhGABA butyric Acid HydrochL Benzenepropanoic acid, β-(aminomethyl)- Phenibut Company Standards Phenibut HCl Powder 4-Amino-3-phenylbutanoic acid USP/EP/BP Phenibut, 4-Amino-3-phenylbutanoic acid Fenibut Phenibut Hot Sale Phenibut Powder 99% Phenibut/Phenibut HCl CAS?1078-21-3 PHENIBUT 4-Amino-3-Phenylbutanoic Acid/Phenibut Phenibut beta-(aminomethyl) hydrocinnamicacid beta-phenyl-gamma- aminobutyrate Phenibut(Fenibut) Phenibut hcl(4-Amino-3-(4-fluorophenyl)butyric acid hydrochloride)