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ChemicalBook >> CAS DataBase List >>3-Tropanyl-3,5-dichlorobenzoate

3-Tropanyl-3,5-dichlorobenzoate

3-Tropanyl-3,5-dichlorobenzoate Structure
3-Tropanyl-3,5-dichlorobenzoate structure
CAS No.
40796-97-2
Chemical Name:
3-Tropanyl-3,5-dichlorobenzoate
Synonyms
bemesetron;MDL-72222;MLD-72222;Benesetron;Bemesetron (MDL 72222);tropyl3,5-dichlorobenzoate;MNJNPLVXBISNSX-WDNDVIMCSA-N;tropine 3,5-dichlorobenzoate;TROPANYL 3,5-DICHLOROBENZOATE;3-Tropanyl-3,5-dichlorobenzoate
CBNumber:
CB2317210
Molecular Formula:
C15H17Cl2NO2
Molecular Weight:
314.21
MDL Number:
MFCD00865533
MOL File:
40796-97-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:50:37
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3-Tropanyl-3,5-dichlorobenzoate Properties

Melting point 165 °C
Boiling point 406.5±45.0 °C(Predicted)
Density 1.34±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility 0.1 M HCl: slightly soluble
pka 9.89±0.40(Predicted)
form solid
color white
Water Solubility Soluble to 100 mM in DMSO. Insoluble in water. Sparingly soluble in chloroform, and ethanol.
FDA UNII O98T3677PA

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501
Hazard Codes  T
Risk Statements  25
Safety Statements  36
WGK Germany  3
RTECS  DG7580000

3-Tropanyl-3,5-dichlorobenzoate price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 43507 MDL 72222 ≥98% 40796-97-2 10mg $61 2026-04-30 Buy
Cayman Chemical 43507 MDL 72222 ≥98% 40796-97-2 25mg $137 2026-04-30 Buy
Cayman Chemical 43507 MDL 72222 ≥98% 40796-97-2 50mg $197 2026-04-30 Buy
Cayman Chemical 43507 MDL 72222 ≥98% 40796-97-2 100mg $363 2026-04-30 Buy
Usbiological 454251 MDL-72222 40796-97-2 50mg $446 2026-06-03 Buy
Product number Packaging Price Buy
43507 10mg $61 Buy
43507 25mg $137 Buy
43507 50mg $197 Buy
43507 100mg $363 Buy
454251 50mg $446 Buy

3-Tropanyl-3,5-dichlorobenzoate Chemical Properties, Uses, Production

Originator

Bemesetron,Merrel Dow

Uses

Anti-emetic.

Uses

It is most often used to study the role of SR-3. Studies suggest the blockade of SR-3 with may ameliorate beta-amyloid protein-induced neurotoxicity by interfering with the increase of Ca2+, and then by inhibiting glutamate release, generation of reactive oxygen species and caspase-3 activity. It is also used in the study of dopamine elevation in rats due to cocaine and amphetamine consumption.

Manufacturing Process

Tropine (34.24 g) is treated with anhydrous diethyl ether and ethereal hydrogen chloride and the precipitated hydrochloride is isolated by evaporation of the solvent. 3,5-Dichlorobenzoylchloride (51.7 g) is added and the mixture stirred at 140°C for 15 minutes during which time the mixture liquifies, evolves hydrogen chloride gas and resolidifies. After heating for a further 15 minutes the cooled solid is dissolved in water, an excess of an aqueous solution of potassium carbonate is added, and the base is extracted with ethyl acetate. Evaporation of the dried ethyl acetate solution yields a solid, which is recrystallized from aqueous methanol to yield 3,5- dichlorobenzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-1-yl ester (endo). MP: 95°C (51.8 g).

Therapeutic Function

Serotonin antagonist

Biological Activity

5-HT 3 antagonist.

storage

Store at RT

3-Tropanyl-3,5-dichlorobenzoate Preparation Products And Raw materials

Raw materials

Tropine 3,5-Dichlorobenzoyl chloride

Preparation Products

3-Tropanyl-3,5-dichlorobenzoate Suppliers

Global Suppliers ( 85)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9331 58
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9790 55
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
Jiangsu aikang biomedical research and development co., LTD 025-58859352 17714375163 qzhang@aikonchem.com China 15525 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
BOC Sciences 65
Bide Pharmatech Ltd. 60
Finetech Industry Limited 58
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Fan De(Beijing) Biotechnology Co., Ltd. 58
Jiangsu aikang biomedical research and development co., LTD 58

View Latest Price from 3-Tropanyl-3,5-dichlorobenzoate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bemesetron pictures 2026-07-14 Bemesetron
40796-97-2
 $30.00-38.00 99.77% 10g TargetMol Chemicals Inc.
Bemesetron pictures 2026-07-14 Bemesetron
40796-97-2
 $30.00-38.00 99.77% 10g TargetMol Chemicals Inc.
  • Bemesetron pictures
  • Bemesetron
    40796-97-2
  • $30.00-38.00
  • 99.77%
  • TargetMol Chemicals Inc.
  • Bemesetron pictures
  • Bemesetron
    40796-97-2
  • $30.00-38.00
  • 99.77%
  • TargetMol Chemicals Inc.

3-Tropanyl-3,5-dichlorobenzoate Spectrum

3-TROPANYL-3,5-DICHLOROBENZOATE(40796-97-2)1HNMR

40796-97-2 (3-Tropanyl-3,5-dichlorobenzoate) Related Search:

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endo-Tropacocaine (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) benzoate HCl 4-Benzyloxy-piperidine hydrochloride

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MDL-72222 TROPANYL 3,5-DICHLOROBENZOATE 3,5-dichloro-,8-methyl-8-azabicyclo(3.2.1)oct-3-ylester,endo-benzoicaci Bemesetron (Synonyms: MDL 72222) Bemesetron (MDL 72222) 3,5-dichloro-benzoicaci(3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yles endo-8-methyl-8-azabicyclo(3.2.1)oct-3-yl3,5-dichlorobenzoate tropyl3,5-dichlorobenzoate tropine 3,5-dichlorobenzoate (1β,5β)-Tropane-3α-ol 3,5-dichlorobenzoate 3,5-Dichlorobenzoic acid (1β,5β)-8-methyl-8-azabicyclo[3.2.1]octan-3α-yl ester Benesetron MLD-72222 MNJNPLVXBISNSX-WDNDVIMCSA-N (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate Benzoic acid, 3,5-dichloro-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester Endo-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate rel-(1R,5R)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate MDL 72222, 5-HT3 receptor antagonist bemesetron 3-Tropanyl-3,5-dichlorobenzoate 40796-97-2 C15H17Cl2NO2 Analytical Standards Analytical Chromatography Product Catalog Forensic and Veterinary Standards Drug Standards Chromatography Serotonin receptor