Palonosetron Hydrochloride

Palonosetron Hydrochloride Properties

Melting point	>290°C
alpha	D25 -94.1° (c = 0.4 in water)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Methanol (Slightly, Heated), Water (Slightly)
form	Solid
color	White to Off-White
optical activity	[α]/D -90 to -110°, c =0.4 in H2O
Water Solubility	H2O: 20mg/mL, clear
Merck	14,6997
InChI	InChI=1/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/s3
InChIKey	OLDRWYVIKMSFFB-HYCRUXCXNA-N
SMILES	N1(C[C@@]2([H])CCCC3=CC=CC(=C32)C1=O)[C@H]1[C@]2([H])CCN(CC2)C1.Cl \|&1:2,15,16,r\|
CAS DataBase Reference	135729-62-3(CAS DataBase Reference)
NCI Dictionary of Cancer Terms	Aloxi; palonosetron hydrochloride
FDA UNII	23310D4I19
NCI Drug Dictionary	Aloxi
UNSPSC Code	41116107
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H332-H302-H312
Precautionary statements	P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312
WGK Germany	WGK 3
HS Code	29339900
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

Palonosetron Hydrochloride price More Price(83)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1195	Palonosetron hydrochloride ≥98% (HPLC)	135729-62-3	10 mg	$143	2026-04-30	Buy
Sigma-Aldrich	SML1195	Palonosetron hydrochloride ≥98% (HPLC)	135729-62-3	50 mg	$557	2026-04-30	Buy
Sigma-Aldrich	PHR2552	Palonosetron Hydrochloride	135729-62-3	200 mg	$236	2026-04-30	Buy
TCI Chemical	P2051	Palonosetron Hydrochloride >98.0%(HPLC)(T)	135729-62-3	200mg	$136	2026-04-30	Buy
TCI Chemical	P2051	Palonosetron Hydrochloride >98.0%(HPLC)(T)	135729-62-3	1g	$435	2026-04-30	Buy

Product number	Packaging	Price	Buy
SML1195	10 mg	$143	Buy
SML1195	50 mg	$557	Buy
PHR2552	200 mg	$236	Buy
P2051	200mg	$136	Buy
P2051	1g	$435	Buy

Palonosetron Hydrochloride Chemical Properties, Uses, Production

Nausea and vomiting drug

Palonosetron hydrochloride is a drug to inhibit nausea and vomiting, which is a new type highly selective, high-affinity 5-HT3 receptor antagonist that can block the vomiting reflex center peripheral neurons presynaptic 5-HT. Receptor excitement directly affects the central nervous system in 5-HT. Impulse receptor excitement generated by the role of vagal afferent nerve after area, blocking the vagus nerve endings in the gut, preventing signals to 5-HT. Receptor trigger zone can reduce the incidence of nausea and vomiting. Central clinically for the treatment of acute severe emetogenic chemotherapy induced delayed nausea and vomiting. Because of its high curative effect, little side effect, long half-life (about 40 h), small dosage, and so on, it has attracted much attention.
With 1,2,3,4-tetrahydro-1-naphthoic acid as the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron.
Clinical studies showed that palonosetron can be used safely with corticosteroids, analgesics, antiemetics, antispasmodics and anticholinergic drugsas the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron.
Murine tumor model studies indicate that palonosetron does not inhibit the five kinds of chemotherapy drugs studied (cisplatin, cyclophosphamide, cytarabine, doxorubicin and mitomycin C) anti-cancer activity.

Adverse effects

The most common adverse effects are headache, which occurs in 4–11% of patients, and constipation in up to 6% of patients. In less than 1% of patients, other gastrointestinal disorders occur, as well as sleeplessness, first-and second-degree atrioventricular block, muscle pain and shortness of breath. Palonosetron is similarly well tolerated as other setrons, and slightly less than placebo.

References

https://en.wikipedia.org/wiki/Palonosetron

Description

Palonosetron is a novel 5-HT3 receptor antagonist launched as an injectable agent for the prevention of acute and delayed nausea and vomiting associated with cancer chemotherapy. It has a much longer half-life (～ 40 h) than the other currently available 5-HT3 antagonists, which provides efficacy advantages in the prevention of delayed nausea and vomiting that typically occurs after 24 h and up to six days post chemotherapy administration. Palonosetron was developed as a conformationally restricted analog of the previously known 5HT3 antagonists tropisetron and granisetron. It is synthesized in four steps starting with the condensation of 1,8- naphthalic anhydride and (S)-3-aminoquinuclidine to produce the corresponding imide. The subsequent steps include catalytic hydrogenation of one of the aromatic rings of the imide intermediate, selective reduction of one of the carbonyls to a hydroxyl group, dehydration to an olefin and catalytic hydrogenation. The recommended dosage of palonosteron is 0.25 mg, administered as a single intravenous dose approximately 30 min before the start of chemotherapy. Palonosetron exhibits dose-proportional pharmacokinetics and it is moderately bound to plasma proteins (62%). Fifty percent of the dose is metabolized in the liver, and 40% is excreted unchanged in the urine. In comparative clinical studies with two other 5- HT3 receptor antagonists, palonosetron is shown to be as effective as dolasetron and more effective than ondansetron in controlling acute nausea and vomiting and superior to both in the control of delayed nausea and vomiting. Efficacy of palonosetron has been demonstrated in patients receiving initial and repeat courses of both moderately and highly emetogenic chemotherapy, including cisplatin, cyclophosphamide and dacarbazine. At 0.25 and 0.75 mg doses, palonosetron is well tolerated and the most occurring adverse events are headache, diarrhea, fatigue, abdominal pain and insomnia.

Chemical Properties

White Solid

Originator

Syntex (Roche Bioscience) (US)

Uses

(S,S)-Palonosetron Hydrochloride is a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.

Uses

Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting

Uses

specifically inhibits cells of the adrenal cortex and their production of hormones for adrenocortical tumor therapy, causes CNS damage, but no bone marrow depression.

Uses

Palonosetron is a potent, selective antagonist of the serotonin (5-HT) receptor 5-HT3 (pKi = 10.4 in rat cortex) that minimally effects a wide range of other neuronal receptors. It is orally bioavailable and potently inhibits emesis induced by chemotherapeutic drugs, like cisplatin , but not by apomorphine , which acts by dopamine receptor antagonism. Palonosetron is remarkable for its long duration of action, related to its high receptor-binding affinity and long half-life. It is effective in managing chemotherapy-induced nausea and vomiting.[Cayman Chemical]

Definition

ChEBI: A hydrochloride obtained by combining palonosetron with one molar equivalent of hydrogen chloride; an antiemetic used in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.

brand name

Aloxi (Helsinn).

storage

Store at -20°C

Palonosetron Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Palonosetron Hydrochloride Suppliers

Global Suppliers ( 564)

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Lenny Technology Co. , Ltd.	571-88086013	sunnie@rdpharm.com	China	105	60
Jinan Hongkangda Chemical Co., Ltd	0531-88901705 18753193522	810353473@qq.com	China	156	58
Chengdu Miracle Pharmaceutical Co., Ltd.	028-86136736 19130631884	sales@mic-pharma.com	China	346	56
Jiangsu Aosaikang Pharmaceutical Co., Ltd	13585114296 13585114296	liuhongwei@ask-pharm.com	China	1122	58
Nova(Shanghai) Pharmaceutical Co.,Ltd	21-58226973 18917146209	Joseph@novapharmas.com	China	478	55
Shanghai Zhen Li Biological Technology Co., Ltd	021-16621358918; 18516310516;16621358918;13045646768	zhenlipharma888@163.com	China	19060	58
Jiangsu Simcere Pharmaceutical CO.,Ltd	025-85566666-7321 15195996671	API@simcere.com	China	22	58
HANGZHOU DUHE CHEMICAL&TECHNOLOGY CO.,LTD	0571-89905385 13858109112	sales@hetapharm.com	China	140	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
Hangzhou Lenny Technology Co. , Ltd.	60
Jinan Hongkangda Chemical Co., Ltd	58
Chengdu Miracle Pharmaceutical Co., Ltd.	56
Jiangsu Aosaikang Pharmaceutical Co., Ltd	58
Nova(Shanghai) Pharmaceutical Co.,Ltd	55
Shanghai Zhen Li Biological Technology Co., Ltd	58
Jiangsu Simcere Pharmaceutical CO.,Ltd	58
HANGZHOU DUHE CHEMICAL&TECHNOLOGY CO.,LTD	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76

View Latest Price from Palonosetron Hydrochloride manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-14	Palonosetron Hydrochloride 135729-62-3	1g	More Than 99%	50kg/Month	BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
2026-09-14	Palonosetron Hydrochloride 135729-62-3	1kg	99.0%	50	Jinan Hong Kongda Chemical Co.,LTD
2026-09-11	Palonosetron Hydrochloride 135729-62-3	10g	99%min	10kg	WUHAN FORTUNA CHEMICAL CO., LTD

Palonosetron Hydrochloride
135729-62-3
$0.00
More Than 99%
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Palonosetron Hydrochloride
135729-62-3
$0.00
99.0%
Jinan Hong Kongda Chemical Co.,LTD

Palonosetron Hydrochloride
135729-62-3
$0.00
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

Palonosetron Hydrochloride Spectrum

Palonosetron Hydrochloride(135729-62-3)¹HNMR

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Palonosetron PALONOSETRON HCL,(3as)-2-(3s)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1h-benz[de]isoquinolin-1-one monohydrochloride 2-(piperidin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline

1of4

(S)-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5 Palonosetron hydrochloride, 99.5%, a 5-HT3 antagonist PALONOSETRON HYDROCHLORIDE CS-292 Palonosetronhydrochloride hydrochloride Palonosetron-d3 HCl (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride Onicit RS-25259-197 (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one monohydrochloride (S,S)-Palonosetron Hydrochloride (S,S)-Palonosetron HCl (3aS)-2-[(S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1-oxo-1H-benz[de]isoquinoline hydrochloride Palonosetron Hydrochloride API 1H-Benz[de]isoquinolin-1-one, 2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-, hydrochloride (1:1), (3aS)- RS 25259 (S)-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride Palonosetron hydrochloride, >=99% Palonosetron HCI PalonosetronHydrochloride> (S)-8-((((S)-quinuclidin-3-yl)amino)methyl)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid Palonosetron Hydrochloride USP/EP/BP a 5-HT3 antagonist PalnosetronHcl Palonosetron HCl (RS25233-197 (5S)-3-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3-azatricyclo[7.3.1.?,13]trideca-1(13),9,11-trien-2-one hydrochloride Palonosetron Hydrochloride (1492200) Methylisothiazolinone free base RS 25259 197|||Palonosetron HCl|||RS 25259 Palonosetron Hydrochlorate Palonosetron hydrochloride, 10 mM in DMSO PALONOSETRON HYDROCHLORIDE (NON-STERILE DRUG SUBSTANCE) Palonosetron HCl - Bio-X ? (s)-2-((1r,3s,4r)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1h-benzo[de]isoquinolin-1-one hydrochloride PALONOSETRON HCL Aloxi 135729-62-3 C19H24N2OHCl C19H25ClN2O C19H24N2OHC Selective 5-HT3 Receptor Antagonist Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals API 135729-62-3