1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid
- CAS No.
- 10250-64-3
- Chemical Name:
- 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid
- Synonyms
- 5-Carboxy-1-methyl-3-phenyl-1H-pyrazole;2-methyl-5-phenyl-pyrazole-3-carboxylic acid;2-Methyl-5-phenyl-2H-pyrazole-3-carboxylic acid;1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid;1H-Pyrazole-5-carboxylic acid, 1-methyl-3-phenyl-;1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid 97%;1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid 95+%;1-methyl-3-phenyl-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE)
- CBNumber:
- CB2329217
- Molecular Formula:
- C11H10N2O2
- Molecular Weight:
- 202.21
- MDL Number:
- MFCD08271939
- MOL File:
- 10250-64-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 186 °C |
|---|---|
| Boiling point | 419.6±33.0 °C(Predicted) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| pka | 2.97±0.25(Predicted) |
| color | White |
| InChI | 1S/C11H10N2O2/c1-13-10(11(14)15)7-9(12-13)8-5-3-2-4-6-8/h2-7H,1H3,(H,14,15) |
| InChIKey | RTBQZMPYPFQBHA-UHFFFAOYSA-N |
| SMILES | Cn1nc(cc1C(O)=O)-c2ccccc2 |
| CAS DataBase Reference | 10250-64-3 |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933199090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
|||||||||
| NFPA 704 |
|
1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | JRD0070 | 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid Aldrich | 10250-64-3 | 1g | $197 | 2026-04-30 | Buy |
| Apolloscientific | OR3884 | 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid >98% | 10250-64-3 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR3884 | 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid >98% | 10250-64-3 | 250mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR3884 | 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid >98% | 10250-64-3 | 1g | $37 | 2026-06-04 | Buy |
| Apolloscientific | OR3884 | 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid >98% | 10250-64-3 | 5g | $112 | 2026-06-04 | Buy |
1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid Chemical Properties,Uses,Production
Synthesis
10250-62-1
10250-64-3
The general procedure for the synthesis of 1-methyl-3-phenyl-1H-pyrazole-5-carboxylic acid from methyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate was as follows: 1-methyl-3-phenyl-1H-pyrazole-5-carboxylic acid methyl ester (1.00 g, 6.23 mmol) was dissolved in a mixed solvent of ethanol (10 mL) and water (10 mL), and then lithium hydroxide mono hydrate (0.582 g, 13.87 mmol). The reaction mixture was stirred at 50 °C until the reaction was complete as monitored by high performance liquid chromatography (HPLC). After completion of the reaction, the mixture was concentrated to dryness and the residue was dissolved in water and extracted with dichloromethane (DCM). The aqueous phase was acidified with 1N hydrochloric acid to pH < 3. The precipitated solid was collected by filtration and dried under high vacuum to afford 1-methyl-3-phenyl-1H-pyrazole-5-carboxylic acid (0.887 g, 95% yield) as a white solid. The mass spectrum (APCI positive ion mode) showed m/z 203 (100%) ([M+H]+).
References
[1] Patent: WO2008/11131, 2008, A2. Location in patent: Page/Page column 260
[2] Chemische Berichte, 1933, vol. 66, p. 1690,1692
[3] Patent: EP1176140, 2002, A1. Location in patent: Page 49 - 50
1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid Preparation Products And Raw materials
1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
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| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
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| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3993 | 55 |
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| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
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