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ChemicalBook >> CAS DataBase List >>L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- Structure
L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- structure
CAS No.
1948273-02-6
Chemical Name:
L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-
Synonyms
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide;VHL ligand 2;(S,R,S)-AHPC-Me;E3 ligase Ligand 1A;CPD101077;E3 ligase Ligand 1 (free base);(S,R,S)-AHPC-Me;L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-;VHL ligand-2,VHL ligand2,Inhibitor,inhibit,Ligands for E3 Ligase,(S,R,S) AHPC Me,(S,R,S)AHPCMe,E3 ligase-recruiting Moiety;(2S,4R)-1-[(S)-2-Amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide
CBNumber:
CB23376069
Molecular Formula:
C23H32N4O3S
Molecular Weight:
444.59
MDL Number:
MFCD31630815
MOL File:
1948273-02-6.mol
MSDS File:
SDS
Last updated:2026-05-11 19:39:08
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L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- Properties

Boiling point 687.9±55.0 °C(Predicted)
Density 1.233±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 14.00±0.40(Predicted)
form Solid
color White to yellow
optical activity -64.41° (c=1.1 CHCI3)
InChIKey JOSFQWNOUSNZBP-UUZHKXTQSA-N
SMILES C(N[C@H](C1=CC=C(C2SC=NC=2C)C=C1)C)(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)(C)C)N
UNSPSC Code 12352101
NACRES NA.22

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth YCD27302 E3 Ligase ligand 1a 1948273-02-6 0.5g $389.4 2026-06-05 Buy
Biosynth YCD27302 E3 Ligase ligand 1a 1948273-02-6 1g $649 2026-06-05 Buy
Biosynth YCD27302 E3 Ligase ligand 1a 1948273-02-6 2g $843.7 2026-06-05 Buy
Biosynth YCD27302 E3 Ligase ligand 1a 1948273-02-6 5g $1103.3 2026-06-05 Buy
Biosynth YCD27302 E3 Ligase ligand 1a 1948273-02-6 10g $1362.9 2026-06-05 Buy
Product number Packaging Price Buy
YCD27302 0.5g $389.4 Buy
YCD27302 1g $649 Buy
YCD27302 2g $843.7 Buy
YCD27302 5g $1103.3 Buy
YCD27302 10g $1362.9 Buy

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- Chemical Properties, Uses, Production

Description

E3 Ligase ligand 1a is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 Ligase ligand 1a can be used to synthesize ARV-771, a BET PROTAC degrader.

Uses

(4R)-3-Methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-L-prolinamide, is a ligand of E3 ligase,

IC 50

VHL

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- Preparation Products And Raw materials

Raw materials

Preparation Products

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- Suppliers

Global Suppliers ( 83)
Supplier Tel Email Country ProdList Advantage
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1644 58
Guangzhou Ruitai Chemical Co., Ltd. 18344585702 550795326@qq.com China 90 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 0431-80514535 19917294565 et@chemextension.com China 5061 58
Abosyn 0512-69561983 13914027025 he_qf@medinoah.com China 3000 58
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 7909 65
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Supplier Advantage
Jilin Province Woda Biotechnology Co., Ltd. 58
Guangzhou Ruitai Chemical Co., Ltd. 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 58
Abosyn 58
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Accela ChemBio Co.,Ltd. 64
Daicel Chiral Technologies (China)CO.,LTD 65
Shanghai Topbiochem Technology Co., Ltd 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58

View Latest Price from L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S,R,S)-AHPC-Me pictures 2026-05-11 (S,R,S)-AHPC-Me
1948273-02-6
 $31.00 99.86% 10g TargetMol Chemicals Inc.

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- Spectrum

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-(1948273-02-6)1HNMR

1948273-02-6 (L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-) Related Search:

E3 ligase Ligand 18 E3 ligase Ligand 10 E3 ligase Ligand 14 rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Cereblon Ligand 1
4-Hydroxy ThalidoMide Protein degrader 1 (TFA) (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione

1of2

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- E3 ligase Ligand 1A CPD101077 E3 ligase Ligand 1 (free base) (2S,4S)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-h ydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phen yl]ethyl]pyrrolidine-2-carboxamide VHL ligand-2,VHL ligand2,Inhibitor,inhibit,Ligands for E3 Ligase,(S,R,S) AHPC Me,(S,R,S)AHPCMe,E3 ligase-recruiting Moiety (2S,4R)-1-[(S)-2-Amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide (2S, 4R) -1- ((S) -2-amino-3,3-dimethylbutyryl) -4-hydroxy-N - ((S) -1- (4- (4-methylthiazol-5-yl) phenyl) ethyl) pyrrolidine-2-formamide (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide (S,R,S)-AHPC-Me (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide - [AC80917] (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide (S,R,S)-AHPC-Me VHL ligand 2 1948273-02-6