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ChemicalBook >> CAS DataBase List >>3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Structure
3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene structure
CAS No.
13669-70-0
Chemical Name:
3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene
Synonyms
NEFOPAM;HCL Nefopam;Nefopan;Nefopami;fenazoxine;(?)-Nefopam;NEFOPAMI HCL;Induced insect;Nefopam HCL CP2000;Nefopanhydrochloride
CBNumber:
CB2379272
Molecular Formula:
C17H19NO
Molecular Weight:
253.34
MDL Number:
MFCD00056181
MOL File:
13669-70-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-20 15:44:49
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3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Properties

Boiling point 396.54°C (rough estimate)
Density 1.0078 (rough estimate)
refractive index 1.5400 (estimate)
storage temp. 2-8°C
pka 9.16±0.70(Predicted)
CAS DataBase Reference 13669-70-0(CAS DataBase Reference)
FDA UNII 4UP8060B7J
ATC code N02BG06

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA001268 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine 98% 13669-70-0 1g $300 2026-05-27 Buy
Crysdot CD31003726 Nefopam 95+% 13669-70-0 1g $299 2026-05-27 Buy
AHH MT-56819 Nefopam 97% 10g $520 2026-05-26 Buy
Biorbyt Ltd orb134818 Nefopanhydrochloride >99% 13669-70-0 100mg $510 2021-12-16 Buy
American Custom Chemicals Corporation API0003526 NEFOPAM 95.00% 13669-70-0 1G $675.15 2021-12-16 Buy
Product number Packaging Price Buy
AA001268 1g $300 Buy
CD31003726 1g $299 Buy
MT-56819 10g $520 Buy
orb134818 100mg $510 Buy
API0003526 1G $675.15 Buy

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Chemical Properties,Uses,Production

Originator

Ajan,Kettelhack Riker,W. Germany,1976

Uses

Nefopam is a non-opioid non-steroidal centrally acting analgesic.

Definition

ChEBI: 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine is a member of the class of benzoxazocines that is 3,4,5,6-tetrahydro-1H-2,5-benzoxazocine substituted by phenyl and methyl groups at positions 1 and 5 respectively. It is a benzoxazocine and a tertiary amino compound.

Manufacturing Process

The starting material is prepared by reacting 2-benzoylbenzoic acid with thionyl chloride and then with 2-methylaminoethanol. 20.0 grams (0.07 mol) of N-(2-hydroxyethyl)-N-methyl-o-benzoylbenzamide is suspended in 100 ml tetrahydrofuran and then slowly added in small portions to a solution of 5.5 grams (0.14 mol) of lithium aluminum hydride in 150 ml tetrahydrofuran with cooling and stirring. The mixture is then refluxed for 18 hours, cooled and then to it is successively added 5.5 ml water, 5.5 ml of 3.75 N sodium hydroxide and 16 ml water. After removal of precipitated salts by filtration, the solution remaining is concentrated under reduced pressure and the residue dried to yield 19.5 grams of crude product. Yield after conversion to the hydrochloride salt and recrystallization is 17.0 grams (89%), MP 128° to 133°C.
5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f] -2,5-oxazocine is prepared as follows. 3.0 grams (0.011 mol) of 2-([N-(2-hydroxyethyl)-Nmethyl]amino)methylbenzhydrol, prepared as described above, 3.0 grams ptoluenesulfonic acid and 15 ml benzene are heated together with stirring until all the benzene is distilled off. The residual oil is heated to 105°C and held at this temperature for 1 hour, then cooled and dissolved in 30 ml water. This aqueous solution is then basified to pH 10.0 with 12 N sodium hydroxide, extracted with ether, and the extracts washed with water, dried over anhydrous sodium sulfate and the solvent removed under reduced pressure. The 2.26 grams (81%) oil remaining is converted to the hydrochloride salt, MP 238° to 242°C.

brand name

Acupan (3M Pharmaceuticals).

Therapeutic Function

Muscle relaxant, Antidepressant

Clinical Use

Nefopam is a centrally acting analgesic without opioid properties. It induces inhibition of NA and 5-HT reuptake and has antimuscarinic and sympatomimetic actions which all might be relevant for its analgesic action. Nefopam is used orally and parenterally for the treatment of moderately severe pain. Side effects are nausea, vomiting, sweating, nervousness, tachycardia, and occasionally convulsions. Nefopam should not be used in combination with MAO inhibitors.

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid Benzophenone Hydrogen bromide Para toluene Potassium borohydride
Benzhydrol Benzoic acid Thionyl chloride Activated carbon Hydrochloric acid
2-Benzoylbenzoic acid 2-Methylaminoethanol Lithium Aluminum Hydride

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Preparation Products

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Suppliers

Global( 87)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Shenzhen Shijingu Technology Co., Ltd (0086)755-61930359 (0086)18038192047 jo@pharmade.com China 279 58
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
AN PharmaTech Co Ltd 86(21)68097365 sales@anpharma.net China 4875 55
Raw material medicin reagent co.,Ltd sales@njromanme.com China 4511 58
Shenzhen Simeiquan Biotechnology Co. Ltd 18126413629 0755-23311925 2355327053 abel@ycgmp.com China 5101 58
Hubei Prosperity Galaxy Chemical CO,.Ltd. 027-83856981 1498703467@qq.com China 241 58
Shenzhen Sendi Biological Technology Co., Ltd. 18124570582 TEL：0755-23574479 2355327139 siliao02@yccreate.com China 6102 58
Wuhai Shuou Technology Co., Ltd. 17792809151;18872220797 2355916837@ycphar.com China 6120 55
Shenzhen SUNGENING Bio-Medical Co., Ltd. 0755-28967200 13631290199 wxf@sungening.com China 9609 60
Supplier Advantage
Shanghai T&W Pharmaceutical Co., Ltd. 58
Shenzhen Shijingu Technology Co., Ltd 58
Quality Control Solutions Ltd. 56
AN PharmaTech Co Ltd 55
Raw material medicin reagent co.,Ltd 58
Shenzhen Simeiquan Biotechnology Co. Ltd 58
Hubei Prosperity Galaxy Chemical CO,.Ltd. 58
Shenzhen Sendi Biological Technology Co., Ltd. 58
Wuhai Shuou Technology Co., Ltd. 55
Shenzhen SUNGENING Bio-Medical Co., Ltd. 60

View Lastest Price from 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene USP/EP/BP pictures 2026-08-20 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene USP/EP/BP
13669-70-0
 $1.10 1g 99.9% 100 Tons Min Dideu Industries Group Limited
Nefopam pictures 2024-01-18 Nefopam
13669-70-0
 $120.00 1kg 99% 8000 Xiamen Wonderful Bio Technology Co., Ltd.
Nefopam pictures 2021-10-29 Nefopam
13669-70-0
 100ASSAYS 99.99% 10000 Jiangsu Monade Biological Technology Co., Ltd.
  • Nefopam pictures
  • Nefopam
    13669-70-0
  • $120.00
  • 99%
  • Xiamen Wonderful Bio Technology Co., Ltd.
  • Nefopam pictures
  • Nefopam
    13669-70-0
  • $0.00
  • 99.99%
  • Jiangsu Monade Biological Technology Co., Ltd.

13669-70-0(3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene)Related Search:

2-(Benzyloxy)-1-ethanamine hydrochloride 2-(Benzyloxy)-ethylamine Nefopam hydrochloride tofenacin 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene
Diphenhydramine N-Benzyl-N-methylethanolamine Diphenhydramine Hydrochloride 2-Methylbenzhydrol N,N-dimethylbenzylamine hydrochloride
[2-(aminomethyl)phenyl]methanol tofenacin hydrochloride 2-(Diphenylmethoxy)-N-methylethylamine 1-Phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine-5-carbonitrile 2-methyl-benzenemethanaminhydrochloride
CHEMBRDG-BB 9071568

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3-methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene 3,4,5,6-tetrahydro-5-methyl-1-phenyl-1h-2,5-benzoxazocine 3,4,5,6-tetrahydro-5-methyl-1-phenyl-1h-5-benzoxazocine fenazoxine NEFOPAMI HCL Nefopam HCL CP2000 Nefopanhydrochloride Nefopami hydrochloride Nefopami Nefopam (base and/or unspecified salts) 1H-2,5-Benzoxazocine,3,4,5,6-tetrahydro-5-Methyl-1-phenyl- 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine Nefopan Induced insect (?)-Nefopam 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene USP/EP/BP HCL Nefopam NEFOPAM 13669-70-0 156-2-24 C17H19NO ACTIVE PHARMACEUTICAL INGREDIENTS