2-Aminothiazole-5-carbonitrile
- CAS No.
- 51640-52-9
- Chemical Name:
- 2-Aminothiazole-5-carbonitrile
- Synonyms
- 2-Amino-1,3-thiazole-5-carbonitrile;2-AMINO-5-CYANOTHIAZOLE;2-Amino-5-cyano-1,3-thiazole;2-aMino-5-thiazolecarbonitrile;2-Aminothiazole-5-carbonitrile;5-thiazolecarbonitrile, 2-amino-;2-Aminothiazole-5-carbonitrile 97%;2-Aminothiazole-5-carbonitrile, 98%,;2-AMINOTHIAZOLE-5-CARBONITRILE, 95+%;2-Amino-1,3-thiazole-5-carbonitrile 97%
- CBNumber:
- CB2386830
- Molecular Formula:
- C4H3N3S
- Molecular Weight:
- 125.15
- MDL Number:
- MFCD08275724
- MOL File:
- 51640-52-9.mol
- MSDS File:
- SDS
| Melting point | 185-187 |
|---|---|
| Boiling point | 330.4±15.0 °C(Predicted) |
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| pka | 1.82±0.10(Predicted) |
| form | solid |
| color | Dark brown |
| InChI | 1S/C4H3N3S/c5-1-3-2-7-4(6)8-3/h2H,(H2,6,7) |
| InChIKey | YJTBHWXNEMGNDC-UHFFFAOYSA-N |
| SMILES | Nc1ncc(s1)C#N |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| RIDADR | UN3439 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HazardClass | IRRITANT | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 2934100090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 |
|||||||||
| NFPA 704 |
|
2-Aminothiazole-5-carbonitrile price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 714801 | 2-Aminothiazole-5-carbonitrile 97% | 51640-52-9 | 1g | $100 | 2023-06-20 | Buy |
| Activate Scientific | AS30434 | 2-Aminothiazole-5-carbonitrile 97% | 51640-52-9 | 1g | $56 | 2026-06-04 | Buy |
| Activate Scientific | AS30434 | 2-Aminothiazole-5-carbonitrile 97% | 51640-52-9 | 5g | $186 | 2026-06-04 | Buy |
| Apolloscientific | OR3230 | 2-Amino-1,3-thiazole-5-carbonitrile 97% | 51640-52-9 | 250mg | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS30434 | 2-Aminothiazole-5-carbonitrile 97% | 51640-52-9 | 25g | $614 | 2026-06-04 | Buy |
2-Aminothiazole-5-carbonitrile Chemical Properties, Uses, Production
Synthesis
51640-51-8
51640-52-9
5-Cyano-2-trifluoroacetamido thiazole (3.32 g, 15 mmol) was used as raw material, and it was reacted with potassium carbonate (4.0 mL 10% w/v methanol/water (5:2) solution) for 3 hours at 20°C with stirring. After completion of the reaction, the insoluble material was removed by filtration, and the pH of the filtrate was adjusted to 7 with dilute hydrochloric acid and filtered again to remove the insoluble material. Subsequently, the filtrate was evaporated to remove volatiles. The residue was suspended in water and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous magnesium sulfate and evaporated to remove the solvent. The resulting residue was treated with 20% aqueous fluoboric acid (40 mL) and heated at 70 °C for 1 hour. The reaction mixture was cooled, neutralized with solid sodium bicarbonate at 0 °C and extracted with ethyl acetate. The organic phases were combined, dried over anhydrous magnesium sulfate and evaporated to remove volatiles to give 2-amino-5-cyanothiazole (1.79 g, 95% yield) as a final solid product. The product was confirmed by NMR hydrogen spectrum (400.13 MHz): δ 7.83 (1H, s), 8.12 (2H, s); mass spectrum (m/z): 125 [MH]+.
References
[1] Patent: WO2007/31745, 2007, A1. Location in patent: Page/Page column 102-103
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973, p. 2769 - 2772
2-Aminothiazole-5-carbonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 |
View Latest Price from 2-Aminothiazole-5-carbonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 2-AMINOTHIAZOLE-5-CARBONITRILE
51640-52-9
|
$1.00 | 1ASSAYS | 85.0-99.8% | 20tons | Career Henan Chemical Co |
-
- 2-AMINOTHIAZOLE-5-CARBONITRILE
51640-52-9
- $1.00
- 85.0-99.8%
- Career Henan Chemical Co
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