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5-Cyanothiazole

5-Cyanothiazole Structure
5-Cyanothiazole structure
CAS No.
25742-12-5
Chemical Name:
5-Cyanothiazole
Synonyms
THIAZOLE-5-CARBONITRILE;5-Cyanothiazole;Thiazol-5-carbonitrile;5-Thiazolecarbonitrile;1,3-thiazole-5-carbonitrile;5-Thiazolecarbonitrile (8CI, 9CI, ACI);Thiazole-5-carbonitrile , 5-Cyanothiazole
CBNumber:
CB42448547
Molecular Formula:
C4H2N2S
Molecular Weight:
110.14
MDL Number:
MFCD06797206
MOL File:
25742-12-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:40
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5-Cyanothiazole Properties

Melting point 53 °C
Boiling point 90-93 °C(Press: 15 Torr)
Density 1.33
storage temp. Sealed in dry,Room Temperature
pka -0.40±0.10(Predicted)
Appearance Yellow to brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS07,GHS08
Signal word  Warning
Hazard statements  H315-H332-H319-H371-H312-H335-H302
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P261-P271-P304+P340-P312-P260-P264-P270-P309+P311-P405-P501-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501
Hazard Codes  Xn
Risk Statements  22
HS Code  2934100090

5-Cyanothiazole price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR905805 5-Cyanothiazole >98% 25742-12-5 250mg $26 2026-06-04 Buy
Apolloscientific OR905805 5-Cyanothiazole >98% 25742-12-5 1g $88 2026-06-04 Buy
Apolloscientific OR905805 5-Cyanothiazole >98% 25742-12-5 5g $379 2026-06-04 Buy
Apolloscientific OR905805 5-Cyanothiazole >98% 25742-12-5 25g $1721 2026-06-04 Buy
Activate Scientific AS33397 5-Cyanothiazole 98% 25742-12-5 1g $136 2026-06-04 Buy
Product number Packaging Price Buy
OR905805 250mg $26 Buy
OR905805 1g $88 Buy
OR905805 5g $379 Buy
OR905805 25g $1721 Buy
AS33397 1g $136 Buy

5-Cyanothiazole Chemical Properties, Uses, Production

Synthesis

5-Thiazolecarboxaldehyde, oxime

116045-57-9

5-CYANOTHIAZOLE

25742-12-5

1,3-Thiazole-5-carboxaldehyde oxime (2.5 g, 19.5 mmol, 1 eq.) was used as a starting material, which was dissolved in 12 mL of dioxane, followed by the addition of triethylamine (TEA, 6.8 mL, 2.5 eq.). The reaction mixture was cooled to 0 °C and trifluoroacetic anhydride (3.0 mL, 1.1 eq.) was added slowly and dropwise. The reaction solution was stirred overnight at room temperature and then trifluoroacetic anhydride (1.1 eq.) was added again to ensure complete reaction. Stirring was continued overnight at room temperature followed by solvent evaporation. The residue was dissolved in dichloromethane (DCM) and washed five times with water. The organic layer was dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to give 1.25 g of 1,3-thiazole-5-carbonitrile in 58% yield.

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 1, p. 68 - 83
[2] Patent: WO2013/60744, 2013, A2. Location in patent: Page/Page column 11; 12

5-Cyanothiazole Preparation Products And Raw materials

Raw materials

5-Thiazolecarboxaldehyde, oxime Thiazole-5-carboxaldehyde Dichloromethane Triethylamine Trifluoroacetic anhydride

Preparation Products

5-Cyanothiazole Suppliers

Global Suppliers ( 59)
Supplier Tel Email Country ProdList Advantage
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. 21-54820552 17702105771 188738128@qq.com China 300 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3996 55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. +86-28-85122536 85324413 market@astatech.cn China 8016 55
ShangHai Wisacheam Pharmaceutical Co., Ltd. 13817485796 tim@wisacheampharm.com China 3698 58
Yancheng Schiemann Biological Technology Co.,Ltd 0515-88280676; 18921872653 sales@ximanbio.com China 1524 56
Supplier Advantage
PharmaBlock Sciences (Nanjing),Inc. 55
Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Pure Chemistry Scientific Inc. 62
Nanjing Chemlin Chemical Co., Ltd 64
China DongFan Chemical Co.,LTD 66
Chiba Pharmaceutical Science and technology Co, Ltd. 55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. 55
ShangHai Wisacheam Pharmaceutical Co., Ltd. 58
Yancheng Schiemann Biological Technology Co.,Ltd 56

View Latest Price from 5-Cyanothiazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-Cyanothiazole pictures 2021-07-02 5-Cyanothiazole
25742-12-5
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
  • 5-Cyanothiazole pictures
  • 5-Cyanothiazole
    25742-12-5
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

5-Cyanothiazole Spectrum

5-CYANOTHIAZOLE(25742-12-5)1HNMR

25742-12-5 (5-Cyanothiazole) Related Search:

2-Aminothiazole-5-carbonitrile 5-Cyanothiazole 2-Chlorothiazole-5-carbonitrile 2-Amino-4-(tert-butyl)-1,3-thiazole-5-carbonitrile 4-Amino-2-methylthiothiazole-5-carbonitrile
2-[2-(Dimethylamino)vinyl]-4-(trifluoromethyl)-1,3-thiazole-5-carbonitrile 4-Methyl-2-phenyl-1,3-thiazole-5-carbonitrile 2-(Aminomethyl)thiazole-5-carbonitrile hydrochloride 2-[2-(4-Methoxyanilino)vinyl]-4-(trifluoromethyl)-1,3-thiazole-5-carbonitrile 2-(2-([(4-Chlorobenzyl)oxy]imino)ethyl)-4-(trifluoromethyl)-1,3-thiazole-5-carbonitrile
4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbonitrile 2-Methyl-4-(trifluoromethyl)-1,3-thiazole-5-carbonitrile 4-chloro-2-[(2-pyridinylmethyl)amino]-1,3-thiazole-5-carbonitrile 2-(benzylamino)-4-chloro-1,3-thiazole-5-carbonitrile 4-chloro-2-[(2-thienylmethyl)amino]-1,3-thiazole-5-carbonitrile
4-chloro-2-[(2-hydroxypropyl)amino]-1,3-thiazole-5-carbonitrile N-(4-chloro-5-cyano-1,3-thiazol-2-yl)-4-methylbenzenecarboxamide 2-[2-(4-Chloroanilino)vinyl]-4-(trifluoromethyl)-1,3-thiazole-5-carbonitrile

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1,3-thiazole-5-carbonitrile 5-Thiazolecarbonitrile 5-Thiazolecarbonitrile (8CI, 9CI, ACI) Thiazole-5-carbonitrile , 5-Cyanothiazole Thiazol-5-carbonitrile THIAZOLE-5-CARBONITRILE 5-Cyanothiazole 25742-12-5