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MCA-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2

MCA-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 structure

CAS No.: 140430-53-1

Chemical Name:: MCA-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2

Synonyms: MCA-PLGL-DPA-AR-NH2;MMP-2/MMP-7 SUBSTRATE;MCA-PLGL-DAP(DNP)-AR-NH2;390 MMP FRET SUBSTRATE I;MCA-PLGL-DAP(DNP)-ALA-ARG-NH2;FLUORESCENT PEPTIDE SUBSTRATE I;390 MMP FRET Substrate 1 - 1 mg;MMP-2/MMP-7 SUBSTRATE, FLUOROGENIC;MCA-PRO-LEU-GLY-LEU-DPA-ALA-ARG-NH2;MCA-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2

CBNumber:: CB2397597

Molecular Formula:: C49H68N14O15

Molecular Weight:: 1093.15

MDL Number:: MFCD00210687

MOL File:: 140430-53-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:51:18

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MCA-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 Properties

Density	1.48±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	20% acetic acid: 1mg/mL
pka	12.99±0.46(Predicted)
form	Solid
color	Light yellow to yellow
Appearance	Yellow Powder
InChIKey	RQASLOJQHHELIQ-QJSKOQLASA-N
UNSPSC Code	12352209
NACRES	NA.83

SAFETY

Risk and Safety Statements

WGK Germany	3
Storage Class	11 - Combustible Solids

MCA-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	03-32-5032	MMP-2/MMP-7 Substrate, Fluorogenic Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs).		1MG	$254	2026-04-30	Buy
Cayman Chemical	24149	7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide ≥95%	140430-53-1	500μg	$89	2021-12-16	Buy
Biosynth	MOC-3163-V	MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH₂	140430-53-1	1mg	$270.14	2026-06-04	Buy
Biosynth	FM110896	Mca-Pro-Leu-Gly-Leu-Dap (Dnp)-Ala-Arg-NH2 trifluoroacetate salt	140430-53-1	1mg	$362.09	2026-06-04	Buy
Biosynth	FM110896	Mca-Pro-Leu-Gly-Leu-Dap (Dnp)-Ala-Arg-NH2 trifluoroacetate salt	140430-53-1	2mg	$609.86	2026-06-04	Buy

Product number	Packaging	Price	Buy
03-32-5032	1MG	$254	Buy
24149	500μg	$89	Buy
MOC-3163-V	1mg	$270.14	Buy
FM110896	1mg	$362.09	Buy
FM110896	2mg	$609.86	Buy

MCA-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 Chemical Properties,Uses,Production

Description

7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide is a fluorogenic substrate for matrix metalloproteinases (MMPs). It is ceaved by an MMP to release the fluorescent moiety 7-methoxycoumarin-4-acetyl (Mca), which can be used to quantify MMP activity.

Uses

MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2), MMP-7 and MMP-9. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues[1][2].

Biological Activity

Cell permeable: no', 'Primary Target
Fluorogenic substrate for matrix metalloproteinases (MMPs)', 'Product does not compete with ATP.', 'Reversible: no', 'kcat/Km = 1.7 x 105 M-1sec-1 for MMP-7 and 6.3 x 105 M-¹ sec-¹ for MMP-2

References

[1] Oneda H, et al. Substrate-dependent activation of thermolysin by salt. Biosci Biotechnol Biochem. 2004 Aug;68(8):1811-3. DOI:10.1271/bbb.68.1811
[2] Oneda H, et al. Inhibitory effects of green tea catechins on the activity of human matrix metalloproteinase 7 (matrilysin). J Biochem. 2003 May;133(5):571-6. DOI:10.1093/jb/mvg073

Sequene

Mca-PLGL-Dap(Dnp)-AR-NH2

MCA-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

MCA-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 Suppliers

Global( 82)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing TGpeptide Biotechnology Co.,Ltd.	18115476705	sales@tgpeptide.com	China	3058	58
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
ApexBio Technology LLC	+1-832-696-8203	info@apexbt.com	United States	477	60
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Nanjing Leon Biological Technology Co., Ltd.	025-84523390 -127; 17705183659	sales@njleonbiotech.com	China	5501	55
Nanjing Peptide Biotech Ltd.	025-58361106-805 15951641583	zhao.xu@njpeptide.com	China	9976	55
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919 15967184799	Eric@peptidego.com	China	7872	58

Supplier	Advantage
Nanjing TGpeptide Biotechnology Co.,Ltd.	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
GL Biochem (Shanghai) Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
ApexBio Technology LLC	60
Shanghai YuanYe Biotechnology Co., Ltd.	60
Nanjing Leon Biological Technology Co., Ltd.	55
Nanjing Peptide Biotech Ltd.	55
Hangzhou Peptidego Biotech Co.,Ltd.	58

MCA-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 Spectrum

MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2(140430-53-1)MS

140430-53-1(MCA-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2)Related Search:

Bis(2-aminopropyl)amine 7-Methoxycoumarin N1-(2,4-Dinitro-phenyl)-ethane-1,2-diamine 7-Methoxycoumarin N,N'-Bis(2-aminoethyl)-1,3-propanediamine

2-ethyl-5-nitroaniline 1-NITRO-2-PROPYLBENZENE 4-(1-AMINO-ETHYL)-PHENYLAMINE CHEMBRDG-BB 7932577 MCA-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2

2-(2-NITROPHENYL)ETHANAMINE MOCAC-PRO-LEU-GLY N-(4-NITRO-BENZYL)-FORMAMIDE 3-(2-Hydroxyphenyl)propionamide 3-(4-Nitrophenyl)propan-1-amine

N-(4-Amino-benzyl)-acetamide 3-(2-Nitro-phenyl)-propionaldehyde 3-[(4-Aminophenyl)amino]-propanamide

1of4

MOCAC-PRO-LEU-GLY-LEU-N3-[2,4-DINITROPHENYL]-L-2,3-DIAMINOPROPIONYL-ALA-ARG-NH2 MMP-2/MMP-7 SUBSTRATE MMP-2/MMP-7 SUBSTRATE, FLUOROGENIC MCA-PRO-LEU-GLY-LEU-DPA-ALA-ARG-NH2 MCA-PLGL-DAP(DNP)-ALA-ARG-NH2 MCA-PLGL-DAP(DNP)-AR-NH2 FLUORESCENT PEPTIDE SUBSTRATE I 7-methoxycoumarin-4-acetyl-pro-leu-*gly-leu-B-(2, 7-METHOXYCOUMARIN-4-ACETYL-PRO-LEU-*GLY- LEU-B-(2,4- 7-methoxycoumarin-4-acetyl-pro-leu-gly-leu-β-(2,4-dinitrophenylamino)ala-ala-arg amide 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide 390 MMP FRET SUBSTRATE I (7-METHOXYCOUMARIN-4-YL)ACETYL-L-PROLYL-L-LEUCYLGLYCYL-L-LEUCYL-[N-BETA-(2,4-DINITROPHENYL)-L-2,3-DIAMINOPROPIONYL]-L-ALANYL-L-ARGININE AMIDE 7-METHOXYCOUMARIN-4-ACETYL-PRO-LEU-GLY-LEU-BETA-(2,4-DINITROPHENYLAMINO)ALA-ALA-ARG AMIDE 7-METHOXYCOUMARIN-4-ACETYL-PRO-LEU-GLY-LEU-DNP-(2,3-DIAMINOPROPIONYL)-ALA-ARG, AMIDE MOCAC-PRO-LEU-GLY-LEU-[3-DNP-2,3-DAP]-ALA-ARG, AMIDE MOCAC-PRO-LEU-GLY-LEU-A2PR(DNP)-ALA-ARG-NH2 7-Methoxycoumarin-4-acetyl-Pro-Leu-Gly-Leu-β-(2,4-dinitrophenylamino)Ala-Arg amide MCA-PRO-LEU-GLY-LEU-DAP-ALA-ARG-NH2: MCA-PLGL-DAP-AR-NH2 Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (Mca7-MethoxycouMarin-4-acetyl) 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide 31:PN:WO2005051299 SEQID:215 unclaimed sequence L-Argininamide, 1-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-L-leucylglycyl-L-leucyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-alanyl- 390 MMP FRET Substrate 1 - 1 mg Mca-Pro-Leu-Gly-Leu-Dap (Dnp)-Ala-Arg-NH2 trifluoroacetate salt MCA-PLGL-DPA-AR-NH2 1-[(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-L-leucylglycyl-L-leucyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-alanyl-L-argininamide MCA-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 140430-53-1 C49H68N14O15 BioChemical Biochemicals and Reagents Substrates by Enzyme Matrix metalloproteinase Enzyme Substrates Enzymes, Inhibitors, and Substrates peptides peptide