4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
- CAS No.
- 33763-20-1
- Chemical Name:
- 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
- Synonyms
- AKOS BBS-00004452;IFLAB-BB F1912-0027;5-Carboxy-2-phenylthiazole;4-methyl-2-phenyl-5-thiazolecarboxylate;4-Methyl-2-phenyl-5-thiazolecarboxylicacid;2-Phenyl-4-methyl-5-thiazolecarboxylic acid;4-METHYL-2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID;5-Thiazolecarboxylic acid, 4-methyl-2-phenyl-;4-Methyl-2-phenylthiazole-5-carboxylicacid,97%;4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
- CBNumber:
- CB2409407
- Molecular Formula:
- C11H9NO2S
- Molecular Weight:
- 219.26
- MDL Number:
- MFCD00141955
- MOL File:
- 33763-20-1.mol
| Product description | Number | Pack Size | Price |
| 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylicAcid | B399915 | 250mg | $90 |
| 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid >95% | 043211 | 5g | $70 |
| 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid >95% | 043211 | 500mg | $13 |
| 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid >95% | 043211 | 1g | $19 |
| 4-Methyl-2-(phenyl)-1,3-thiazol-5-carboxylicacid | Z2892 | 1g | $41 |
| More product size | |||
| Melting point | 210-212°C |
|---|---|
| Boiling point | 424.0±37.0 °C(Predicted) |
| Density | 1.319±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 1.20±0.37(Predicted) |
| Appearance | White to off-white Solid |
| CAS DataBase Reference | 33763-20-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-26-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B399915 | 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylicAcid | 33763-20-1 | 250mg | $90 | 2021-12-16 | Buy |
| Matrix Scientific | 043211 | 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid >95% | 33763-20-1 | 5g | $70 | 2021-12-16 | Buy |
| Matrix Scientific | 043211 | 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid >95% | 33763-20-1 | 500mg | $13 | 2021-12-16 | Buy |
| Matrix Scientific | 043211 | 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid >95% | 33763-20-1 | 1g | $19 | 2021-12-16 | Buy |
| AK Scientific | Z2892 | 4-Methyl-2-(phenyl)-1,3-thiazol-5-carboxylicacid | 33763-20-1 | 1g | $41 | 2021-12-16 | Buy |
4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic Acid is a useful reagent in Pd-catalyzed decarboxylative C-H cross-coupling of oxazoles and thiazoles.
Synthesis
53715-64-3
33763-20-1
General method: 2N aqueous sodium hydroxide solution was slowly added to a methanol solution containing ethyl 4-methyl-2-phenyl-1,3-thiazole-5-carboxylate (1 eq.) at room temperature. The reaction mixture was stirred continuously for 4 hours at room temperature. After completion of the reaction, the methanol solvent was removed by rotary evaporator. Subsequently, the pH of the reaction mixture was adjusted to 5-6 with 1N hydrochloric acid solution.The precipitated white solid was collected by filtration and processed by drying to finally give 4-methyl-2-phenylthiazole-5-carboxylic acid (1a-i).
References
[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 4, p. 685 - 695
[2] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 96 - 107
[3] Justus Liebigs Annalen der Chemie, 1974, p. 1195 - 1205
[4] Heterocycles, 2014, vol. 89, # 2, p. 453 - 464
[5] Molecules, 2014, vol. 19, # 7, p. 9240 - 9256
4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8830 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9651 | 58 |
| Hunan Jibang Biological Technology Co., LTD | +8613776644403 | sales02@kingboomtech.com | China | 1804 | 58 |
View Lastest Price from 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
33763-20-1
|
US $1.00 / kg | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
33763-20-1
- US $1.00 / kg
- 98%
- Career Henan Chemical Co
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