|
|
| | 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Basic information |
| Product Name: | 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID | | Synonyms: | 4-METHYL-2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID;4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID;AKOS BBS-00004452;IFLAB-BB F1912-0027;4-Methyl-2-phenyl-5-thiazolecarboxylicacid;4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid, Tech.;5-Carboxy-2-phenylthiazole;2-Phenyl-4-methyl-5-thiazolecarboxylic acid | | CAS: | 33763-20-1 | | MF: | C11H9NO2S | | MW: | 219.26 | | EINECS: | | | Product Categories: | | | Mol File: | 33763-20-1.mol |  |
| | 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Chemical Properties |
| Melting point | 210-212°C | | Boiling point | 424.0±37.0 °C(Predicted) | | density | 1.319±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 1.20±0.37(Predicted) | | Appearance | White to off-white Solid | | CAS DataBase Reference | 33763-20-1(CAS DataBase Reference) |
| | 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Usage And Synthesis |
| Chemical Properties | White solid | | Uses | 4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic Acid is a useful reagent in Pd-catalyzed decarboxylative C-H cross-coupling of oxazoles and thiazoles. | | Synthesis | General method: 2N aqueous sodium hydroxide solution was slowly added to a methanol solution containing ethyl 4-methyl-2-phenyl-1,3-thiazole-5-carboxylate (1 eq.) at room temperature. The reaction mixture was stirred continuously for 4 hours at room temperature. After completion of the reaction, the methanol solvent was removed by rotary evaporator. Subsequently, the pH of the reaction mixture was adjusted to 5-6 with 1N hydrochloric acid solution.The precipitated white solid was collected by filtration and processed by drying to finally give 4-methyl-2-phenylthiazole-5-carboxylic acid (1a-i). | | References | [1] Journal of Medicinal Chemistry, 2007, vol. 50, # 4, p. 685 - 695
[2] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 96 - 107
[3] Justus Liebigs Annalen der Chemie, 1974, p. 1195 - 1205
[4] Heterocycles, 2014, vol. 89, # 2, p. 453 - 464
[5] Molecules, 2014, vol. 19, # 7, p. 9240 - 9256 |
| | 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials |
|