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1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride

1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride structure

CAS No.: 70918-74-0

Chemical Name:: 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride

Synonyms: N-(1,4-BENZODIOXAN-2-CARBONYL)PIPERAZINE HYDROCHLORIDE;TIMTEC-BB SBB003004;Doxazosin iMpurity B;Doxazosin EP IMpurity B;Doxazosin Related CoMpound A;Doxazosin EP Impurity B(HCl);Doxazosin mesylate impurity B;1-[(2RS)-2,3-Dihydro-1,4-benzodioxi;Doxazosin EP Impurity B Hydrochloride;Doxazosin EP Impurity B monohydrochloride

CBNumber:: CB2419783

Molecular Formula:: C13H17ClN2O3

Molecular Weight:: 284.74

MDL Number:: MFCD00729051

MOL File:: 70918-74-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:34:02

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1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride Properties

Melting point	105-108°C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	powder to crystal
color	White to Almost white
Stability	Hygroscopic
Major Application	pharmaceutical
InChI	InChI=1S/C13H16N2O3.ClH/c16-13(15-7-5-14-6-8-15)12-9-17-10-3-1-2-4-11(10)18-12;/h1-4,12,14H,5-9H2;1H
InChIKey	TUKBWYXLYINULI-UHFFFAOYSA-N
SMILES	C12=CC=CC=C1OCC(C(=O)N1CCNCC1)O2.Cl
CAS DataBase Reference	70918-74-0(CAS DataBase Reference)
EWG's Food Scores	1
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08,GHS09

Signal word

Danger

Hazard statements

H301+H311+H331-H373-H411

Precautionary statements

P273-P280-P301+P310-P302+P352+P312-P304+P340+P311-P314

target organs

Liver

Hazard Codes

T;N,Xi,N,T

Risk Statements

23/24/25-48/22-51/53

Safety Statements

45-53-61

RIDADR

UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all

WGK Germany

WGK 3

Hazard Note

Irritant

HazardClass

6.1

PackingGroup

III

HS Code

2934990002

Storage Class

6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects

Hazard Classifications

Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Aquatic Chronic 2
STOT RE 2 Oral

REACH Registrations

Inactive

NFPA 704

	0
2		0

1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride price More Price(67)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR3313	Doxazosin Related Compound A certified reference material, pharmaceutical secondary standard	70918-74-0	50MG	$640	2026-04-30	Buy
Sigma-Aldrich	1225420	Doxazosin Related Compound A	70918-74-0	20mg	$1390	2026-04-30	Buy
TCI Chemical	P1890	2-(1-Piperazinylcarbonyl)-1,4-benzodioxane Hydrochloride >98.0%(HPLC)	70918-74-0	5g	$22	2026-04-30	Buy
TCI Chemical	P1890	2-(1-Piperazinylcarbonyl)-1,4-benzodioxane Hydrochloride >98.0%(HPLC)	70918-74-0	25g	$68	2026-04-30	Buy
Usbiological	264212	N-(1,4-Benzodioxan-2-carbonyl)-piperazine hydrochloride Asreported	70918-74-0	2g	$355	2026-06-03	Buy

Product number	Packaging	Price	Buy
PHR3313	50MG	$640	Buy
1225420	20mg	$1390	Buy
P1890	5g	$22	Buy
P1890	25g	$68	Buy
264212	2g	$355	Buy

1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride Chemical Properties, Uses, Production

Uses

1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine Monohydrochloride (Doxazosin EP Impurity B) is an impurity of Doxazosin (D537500), a selective a1-adrenoceptor antagonist. Doxazosin relaxes smooth muscles of the prostate.

1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride synthesis

Synthesis of 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride from Piperazine and Ethyl 1,4-Benzodioxan-2-carboxylate

1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride Preparation Products And Raw materials

Raw materials

Ethyl 1,4-Benzodioxan-2-carboxylate 2,3-Dihydro-1,4-benzodioxine-2-carbonyl chloride 2-Hydroxymethyl-1,4-benzodioxane Piperazine

Preparation Products

1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride Suppliers

Global Suppliers ( 232)

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Highfine Biotech Co., Ltd	0512-69209928 18796809688	zhouyingxiang@highfine.com	China	1846	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59

Supplier	Advantage
Suzhou Highfine Biotech Co., Ltd	58
J & K SCIENTIFIC LTD.	76
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59

View Latest Price from 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-27	1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride 70918-74-0	$1.00	1KG	99%	200kg	Career Henan Chemical Co

1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride
70918-74-0
$1.00
99%
Career Henan Chemical Co

70918-74-0 (1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride) Related Search:

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1-(1,4-Benzodioxane-2-carbonyl)piperazine 1,4-Benzodioxan Doxazosin 1-(Chloroacetyl)-4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride

1-(3-Chlorophenyl)-4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine 1-(5-Chloro-2-methylphenyl)-4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine Doxazosin mesilate imp. B (EP) as hydrochloride: 1-[(2RS)-2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl]piperazine hydrochloride

1of4

1-(1,4-benzodioxan-2-ylcarbonyl)piperazine hydrochloride N-[(1,4-Benzodioxin-2-yl)carbonyl]piperazine hydrochloride 2-(1-Piperazinylcarbonyl)-1,4-benzodioxane Hydrochloride 4-Benzodioxan-2-carbonyl)-piperazine hydrochloride Doxazosin Related Compound A (20 mg) (N-(1,4-benzodioxane-2-carbonyl)piperazine hydrochloride) Methanone,(2,3-dihydro-1,4-benzodioxin-2-yl)-1-piperazinyl-, hydrochloride (1:1) (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)Methanone hydrochloride N-(1,4-Benzodioxane-2-carbonyl)piperazine Hydrochloride Doxazosin EP IMpurity B N-[(1,4-Benzodioxane-2-yl)carboxyl] piperazine hydrochloride, >=98% N-(1,4-Benzodioxan-2-carbonyl)piperazinehydrochloride98% 1-(1,4-Benzodioxan-2-carbonyl)piperazine*HCl Doxazosin Related CoMpound A (2,3-Dihydrobenzo[1.4]dioxin-2-yl)piperazine-1-yl-methanone N-(2,3-Dihydro-1,4-Benzodioxane-2-Carbonyl)Piperazine HCl N-(1,4-Benzodioxan-2-carbonyl)piperazine hydrochloride 98% (2,3-Dihydro-benzo[1,4]dioxin-2-yl)piperazine- N-(1,4-BENZODIOXANE-2-CARBONYL) PIPERAZINE DIHYDRO 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLCARBONYL)PIPERAZINE HCL 2,3,4a,8a-tetrahydro-1,4-benzodioxin-3-yl(1-piperazinyl)methanone hydrochloride Doxazosin Impurity 2（Doxazosin EP Impurity B） Doxazosin EP Impurity B monohydrochloride RE-CREDIT RE-EXPORT OF QUALITY ISSUE-N (1 4 BENZODIOXAN-2-CARBONYL)-PIPERAZINE (2,3-DIHYDRO-BENZO[1,4]DIOXIN-2-YL)-PIPERAZIN-1-YL-METHANONE HYDROCHLORIDE (2,3-DIHYDRO-BENZO[1,4]DIOXIN-2-YL)PIPERAZINE-1-YL-METHANONE HYDROCHLORIDE 1,4-BENZODIOXAN-2-CARBONYL PIPERAZINE HCL 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride 1-(1,4-BENZODIOXANE-2-CARBONYL)PIPERAZINE HYDROCHLORIDE TIMTEC-BB SBB003004 N-(1,4-BENZODIOXAN-2-CARBONYL)-PIPERAZINE HCL N-[(1,4-BENZODIOXANE-2-YL)CARBONYL]PIPERAZINE HCL N-[(1,4-BENZODIOXANE-2-YL)CARBOXYL] PIPERAZINE HYDROCHLORIDE (2,3-DIHYDRO-BENZO[1,4]DIOXIN-2-YL)-PIPERAZIN-1-YL-METHANONE HCL N-(2,3-DIHYDRO-1,4-BENZODIOXANE-2-CARBONYL)PIPERAZINE HYDROCHLORIDE N-[(1,4-benzodioxane-2-yl)carbonyl]piperazine hydrochloride 1-[(1,4-Benzodioxane-2-Yl)Carboxyl]Piperazine Hydrochloride 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochlorid 2-(1-Piperazinylcarbonyl)-1,4-benzodioxaneHydrochloride> 1-[(2RS)-2,3-Dihydro-1,4-benzodioxi Doxazosin EP Impurity B Hydrochloride Doxazosin EP Impurity B/ Doxazosin Related Compund A 1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydro... Doxazosin Related Compound A (N-(1,4-benzodioxane-2-carbonyl)piperazine hydrochloride) (1225420) Doxazosin EP Impurity B(HCl) Doxazosin Mesilate Impurity B as Hydrochloride Doxazosin Related Compound A as Hydrochloride Doxazosin Mesilate EP Impurity B as Hydrochloride Doxazosin USP Related Compound A as Hydrochloride Doxazosin EP Impurity B HCl (Doxazosin USP Related Compound A) 2-(1-Piperazinylcarbonyl)-1,4-benzodioxane Hydrochloride, ≥ 98.0% Doxazosin iMpurity B l-[(2,3-Dihydro-l,4-Benzodioxan-2-yl) Carbonyl] Piperazine Doxazosin mesylate impurity B N-(1,4-BENZODIOXAN-2-CARBONYL)PIPERAZINE HYDROCHLORIDE 70918-74-0 C13H16N2O3HClC13H17ClN2O3 C13H16N2O3HClC13H17ClN2 C13H17N2O3Cl