Ethyl 1,4-Benzodioxan-2-carboxylate
- CAS No.
- 4739-94-0
- Chemical Name:
- Ethyl 1,4-Benzodioxan-2-carboxylate
- Synonyms
- TIMTEC-BB SBB008613;Doxazosin Impurity 2;Doxazosin Impurity 16;2,3-Dihydro-2-Carboethoxy-1,4-;ETHYL 1,4-BENZODIOXAN-2-CARBOXYLATE;ETHYL 1,4-BENZODIOXANE-2-CARBOXYLATE;Ethyl1,4-Benzodioxane-2-carboxylate>Ethyl 1,4-benzodioxan-2-carboxylate(EBDC);2,3-Dihydro-2-carboethoxy-1, 4-benzodioxane;1,4-BENZODIOXAN-2-CARBOXYLIC ACID ETHYL ESTER
- CBNumber:
- CB4740922
- Molecular Formula:
- C11H12O4
- Molecular Weight:
- 208.21
- MDL Number:
- MFCD01099774
- MOL File:
- 4739-94-0.mol
- TDS File:
- TDS
| Boiling point | 88-95 °C/0.3 mmHg (lit.) |
|---|---|
| Density | 1.208 g/mL at 25 °C |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| form | clear liquid |
| color | Colorless to Yellow to Orange |
| InChI | InChI=1S/C11H12O4/c1-2-13-11(12)10-7-14-8-5-3-4-6-9(8)15-10/h3-6,10H,2,7H2,1H3 |
| InChIKey | DDIGEMWIKJMEIU-UHFFFAOYSA-N |
| SMILES | O1C2=CC=CC=C2OCC1C(OCC)=O |
| CAS DataBase Reference | 4739-94-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 2 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2916399090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Ethyl 1,4-Benzodioxan-2-carboxylate price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E0902 | Ethyl 1,4-Benzodioxane-2-carboxylate >98.0%(GC) | 4739-94-0 | 5g | $109 | 2026-04-30 | Buy |
| TCI Chemical | E0902 | Ethyl 1,4-Benzodioxane-2-carboxylate >98.0%(GC) | 4739-94-0 | 25g | $350 | 2026-04-30 | Buy |
| Usbiological | 419728 | 2,3-Dihydro-1,4-benzodioxin-2-carboxylic Acid Ethyl Ester | 4739-94-0 | 5g | $319 | 2026-06-03 | Buy |
| Usbiological | 419728 | 2,3-Dihydro-1,4-benzodioxin-2-carboxylic Acid Ethyl Ester | 4739-94-0 | 10g | $425 | 2026-06-03 | Buy |
| Biosynth | FE142584 | Ethyl 2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate | 4739-94-0 | 50g | $150 | 2026-06-04 | Buy |
Ethyl 1,4-Benzodioxan-2-carboxylate Chemical Properties, Uses, Production
Uses
2,3-Dihydro-1,4-benzodioxin-2-carboxylic Acid Ethyl Ester is an intermediate used to prepare presynaptic α2-adrenoreceptor antagonists and potential antidepressants. It is also used to prepare aminoalkylbenzodioxins as calcium antagonists.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 5373, 1955 DOI: 10.1021/ja01625a050
Synthesis
120-80-9
3674-13-3
4739-94-0
GENERAL METHOD: A mixture of 12 g (0.11 mol) of catechol, 17.9 g (0.1 mol) of ethyl 2,3-dibromopropionate, and 41.4 g (0.3 mol) of anhydrous K2CO3 was refluxed for 18 hours in 200 mL of anhydrous acetone. Upon completion of the reaction, acetone was removed by distillation under reduced pressure and the residue was dissolved in dichloromethane. The organic phase was washed sequentially with water, 5% NaOH solution, 5% HCl solution and saturated NaCl solution and finally dried with anhydrous Na2SO4. After evaporating the solvent under reduced pressure, the residue was distilled to give 15.4 g (74% yield) of ethyl 1,4-benzodioxane-2-carboxylate.
References
[1] Sangita M. Kasture. “Novel enzymatic route for kinetic resolution of (±)1,4-benzodioxan-2-carboxylic acid.” Biochemical Engineering Journal 27 1 (2005): Pages 66-71.
Ethyl 1,4-Benzodioxan-2-carboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6742 | 52 |
| Shanghai AmasPharm Co., Ltd. | 021-54540637 18621091017 | sales@amaspharm.com | China | 787 | 62 |
View Latest Price from Ethyl 1,4-Benzodioxan-2-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | Ethyl 1,4-Benzodioxane-2-carboxylate
4739-94-0
|
$1.00-1.50 | 1KG | 99% | 100000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2024-07-08 | Ethyl 1,4-benzodioxan-2-carboxylate(EBDC)
4739-94-0
|
$500.00-600.00 | 1kg | 99% | 100kgs/20days | Sach biotech Co.,Ltd | |
 |
2019-07-06 | ETHYL 1,4-BENZODIOXAN-2-CARBOXYLATE
4739-94-0
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- Ethyl 1,4-Benzodioxane-2-carboxylate
4739-94-0
- $1.00-1.50
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Ethyl 1,4-benzodioxan-2-carboxylate(EBDC)
4739-94-0
- $500.00-600.00
- 99%
- Sach biotech Co.,Ltd
-
- ETHYL 1,4-BENZODIOXAN-2-CARBOXYLATE
4739-94-0
- $1.00
- 98%
- Career Henan Chemical Co
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