Methyl (2-chloromethyl)oxazole-4-carboxylate
- CAS No.
- 208465-72-9
- Chemical Name:
- Methyl (2-chloromethyl)oxazole-4-carboxylate
- Synonyms
- METHYL 2-(CHLOROMETHYL)-1,3-OXAZOLE-4-CARBOXYLATE;METHYL 2-CHLOROMETHYL-4-OXAZOLECARBOXYLATE;Methyl (2-chloromethyl)oxazole-4-carboxylate;2-(Chloromethyl)-4-(methoxycarbonyl)-1,3-oxazole;METHYL 2-(CHLROMETHYL)-1,3-OXAZOLE-4-CARBOXYLATE;(2-chloromethyl)azole-4-carboxylic acidmethyl ester;Methyl2-(chloromethyl)-1,3-oxazole-4-carboxylate97%;2-CHLOROMETHYL-OXAZOLE-4-CARBOXYLIC ACID METHYL ESTER;Methyl 2-(chloromethyl)-1,3-oxazole-4-carboxylate 97%;Methyl (2-Chloromethyl)Oxazole-4-Carboxylate(WX630102)
- CBNumber:
- CB2425465
- Molecular Formula:
- C6H6ClNO3
- Molecular Weight:
- 175.57
- MDL Number:
- MFCD06660133
- MOL File:
- 208465-72-9.mol
- MSDS File:
- SDS
Methyl (2-chloromethyl)oxazole-4-carboxylate price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 50698 | METHYL 2-(CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE 95% | 208465-72-9 | 0.25G | $49 | 2026-04-30 | Buy |
| AstaTech | 50698 | METHYL 2-(CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE 95% | 208465-72-9 | 1G | $92 | 2026-04-30 | Buy |
| AstaTech | 50698 | METHYL 2-(CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE 95% | 208465-72-9 | 5G | $290 | 2026-04-30 | Buy |
| Biosynth | IIA46572 | Methyl 2-(chloromethyl)-1,3-oxazole-4-carboxylate | 208465-72-9 | 5g | $354 | 2026-06-04 | Buy |
| Apolloscientific | OR1452 | Methyl 2-(chloromethyl)-1,3-oxazole-4-carboxylate 98% | 208465-72-9 | 250mg | $21 | 2026-06-04 | Buy |
Methyl (2-chloromethyl)oxazole-4-carboxylate Chemical Properties, Uses, Production
Synthesis
3018-12-0
5680-80-8
208465-72-9
GENERAL STEPS: Sodium methanolate (25.00 mg, 0.46 mmol) was dissolved in anhydrous methanol (4.50 mL) and dry dichloromethane (30.00 mL) under nitrogen protection and cooled to 0 °C. Dichloroacetonitrile (5.00 g, 45.50 mmol) was slowly added to this stirred solution and stirring was continued for 1 hour at 0°C. Subsequently, L-serine methyl ester hydrochloride (7.00 g, 45.50 mmol) was added and the reaction mixture was warmed to 25 °C and stirred for 12 hours. Upon completion of the reaction, water was added and the aqueous phase was extracted with dichloromethane (3 x 25.00 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was dissolved in dichloromethane (50.00 mL) and N,N-diisopropylethylamine (11.90 mL, 68.30 mmol) was added. The reaction mixture was stirred at 50 °C for 5 hours, followed by continued stirring at 25 °C for 12 hours. At the end of the reaction, water was added and the aqueous phase was extracted with dichloromethane (3 x 25.00 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The product did not require further purification (quantitative yield).ESI-MS m/z: 176 [M + H]+, 198 [M + Na]+; 1H NMR (300 MHz, CDCl3) δ 3.92 (s, 3H), 4.63 (s, 2H), 8.25 (s, 1H).
References
[1] Tetrahedron Letters, 2016, vol. 57, # 8, p. 920 - 923
Methyl (2-chloromethyl)oxazole-4-carboxylate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
| Bellen Chemistry Co., Ltd. | 010-60400365-8001 15910885229 | service@bellenchem.com | China | 4514 | 60 |
| 3A SpeedChemical Inc | 21-65679720 | service@speedchemical.com | China | 604 | 55 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 |
View Latest Price from Methyl (2-chloromethyl)oxazole-4-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | METHYL (2-CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE
208465-72-9
|
$1.00 | 1kg | 98% | 200KG | Career Henan Chemical Co |
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- METHYL (2-CHLOROMETHYL)OXAZOLE-4-CARBOXYLATE
208465-72-9
- $1.00
- 98%
- Career Henan Chemical Co
