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1,2,3,4-Tetrahydro-9-methylcarbazol-4-one

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Structure
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one structure
CAS No.
27387-31-1
Chemical Name:
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
Synonyms
N-Methylcarbazolone;ONDANSETRON EP IMP C;Ondansetron Impurity C;Ondansetron EP Impurity C;1,2,3,9-Tetrahydro-9-Methyl-4H;Ondansetron Related CoMpound C;Ondansetron impurity C (PhEur);1,2,3,4-tetrahydro-4-oxocarbazolt;1,2,3,9-TETRAHYDRO-4-OXO-CARBAZOLE;Ondansetron USP Related Compound C
CBNumber:
CB2441827
Molecular Formula:
C13H13NO
Molecular Weight:
199.25
MDL Number:
MFCD00173748
MOL File:
27387-31-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:28:56
Request For Quotation

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Properties

Melting point 199.0 to 203.0 °C
Boiling point 383.5±11.0 °C(Predicted)
Density 1.21±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
form solid
color White to Light yellow
BRN 153862
Major Application pharmaceutical (small molecule)
InChI InChI=1S/C13H13NO/c1-14-10-6-3-2-5-9(10)13-11(14)7-4-8-12(13)15/h2-3,5-6H,4,7-8H2,1H3
InChIKey HHJUJCWZKJMCLC-UHFFFAOYSA-N
SMILES N1(C)C2=C(C=CC=C2)C2=C1CCCC2=O
CAS DataBase Reference 27387-31-1(CAS DataBase Reference)
FDA UNII 267IW42T7Z
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301-H412
Precautionary statements  P264-P270-P273-P301+P310-P405-P501
Hazard Codes  Xi,T
Risk Statements  36/37/38-52/53-25
Safety Statements  22-24/25-61-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  WGK 3
HS Code  2933998090
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Aquatic Chronic 3

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2224 Ondansetron Related Compound C Pharmaceutical Secondary Standard; Certified Reference Material 27387-31-1 100mg $443 2026-04-30 Buy
Sigma-Aldrich 1478618 Ondansetron Related Compound C United States Pharmacopeia (USP) Reference Standard 27387-31-1 30mg $1460 2026-04-30 Buy
TCI Chemical T2942 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one >98.0%(GC) 27387-31-1 5g $22 2026-04-30 Buy
TCI Chemical T2942 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one >98.0%(GC) 27387-31-1 25g $73 2026-04-30 Buy
Usbiological 290875 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one NA Asreported 27387-31-1 250g $814 2026-06-03 Buy
Product number Packaging Price Buy
PHR2224 100mg $443 Buy
1478618 30mg $1460 Buy
T2942 5g $22 Buy
T2942 25g $73 Buy
290875 250g $814 Buy

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Chemical Properties,Uses,Production

Chemical Properties

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one is Off-White Solid

Uses

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one is used in the preparation of 5-HT3 modulators useful in the treatment and prevention of 5-HT3 receptor-mediated diseases. 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one is an impurity of Ondansetron (O655000).

Synthesis

1,2,3,9-Tetrahydro-4(H)-carbazol-4-one

15128-52-6

N,N-Dimethylformamide dimethyl acetal

4637-24-5

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one

27387-31-1

The reaction was carried out in N,N-dimethylformamide (5.0 mL) at reflux for 1.0 h with 2,3-dihydro-1H-carbazol-4(9H)-one (1.0 mmol) and N,N-dimethylformamide dimethyl acetal (10 mmol). After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (2 x 25 mL). The organic layer was separated and washed with saturated brine solution and subsequently dried over anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure and the resulting solid was recrystallized from ethanol to give white acicular crystals in 71% yield, melting point 188-190 °C. IR (cm-1 ): 1695 (C=O). 1H NMR (400 MHz, CDCl3) δ: 2.24-2.27 (t, 2H, CH2, J = 6.28 Hz), 2.56-2.59 (t, 2H, CH2, J = 6.0 Hz), 2.56-2.59 (t, 2H, CH2, J = 6.0 Hz). CH2, J = 6.0 Hz), 2.91-2.94 (t, 2H, CH2, J = 6.21 Hz), 3.70 (s, 3H, NCH3), 7.27-7.30 (m, 3H, Ph), 8.24-8.26 (m, 1H, Ph). Calculated elemental analysis (C13H13NO): C, 78.36; H, 6.58; N, 7.03%. Measured values: C, 78.29; H, 6.49; N, 6.92%.

References

[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014, vol. 53B, # 12, p. 1606 - 1610
[2] Journal of Molecular Structure, 2014, vol. 1080, p. 137 - 144
[3] Russian Chemical Bulletin, 2005, vol. 54, # 8, p. 1887 - 1891

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one synthesis

15128-52-6
4637-24-5
27387-31-1
Synthesis of 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one from 1,2,3,9-Tetrahydro-4(H)-carbazol-4-one and N,N-Dimethylformamide dimethyl acetal

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Preparation Products And Raw materials

Raw materials

Acrylic acid Phenylhydrazine 1,2,3,9-Tetrahydro-4(H)-carbazol-4-one N,N-Dimethylformamide dimethyl acetal

Preparation Products

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Suppliers

Global( 316)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Jiecheng Pharmaceutical Co., Ltd 0531-83130525 18560095177 lily.chen@jiechengpharm.com China 25 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
Shandong Jiecheng Pharmaceutical Co., Ltd 58
J & K SCIENTIFIC LTD. 76
INTATRADE GmbH 66
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66
Accela ChemBio Co.,Ltd. 64
Shanghai Longsheng chemical Co.,Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64

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1,2,3,4-Tetrahydro-9-methylcarbazol-4-one pictures 2026-09-11 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
27387-31-1
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one pictures 2026-06-30 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
27387-31-1
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
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27387-31-1
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1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Spectrum

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one(27387-31-1)1HNMR

27387-31-1(1,2,3,4-Tetrahydro-9-methylcarbazol-4-one)Related Search:

Methyl acrylate Basic Violet 1 N-Methyl-2-pyrrolidone Methylparaben Tetramethylammonium hydroxide pentahydrate
Paraquat dichloride Mesotrione Carbazole 1,1,3,3-Tetramethyldisiloxane Methyl tetrahydrophthalic anhydride
6-Methyl-5-hepten-2-one Kresoxim-methyl Methanol Acetonitrile 4-Methyl-2-pentanone
Methyl Ondansetron EP Impurity G 3-[(Dimethylamino)methyl]-9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one

1of4

1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONE 9-METHYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-4-ONE 9-METHYL-1,2,3,9-TETRAHYDRO-CARBAZOL-4-ONE 9-METHYL-1,2,3,9-TETRAHYDRO-4H-CARBAZOL-4-ONE 9-METHYL-1,2,3,4-TETRAHYDRO-4-OXOCARBAZOLE 9-METHYL-1,2.3,4-TETRAHYDRO-4-OXOCARBAZOLE-4-ONE Ondansetron EP Impurity C (USP RC C) 1,2,3,4a,9,9a‐Hexahydro‐9‐ methyl‐4H‐carbazol‐4‐one 9-Methyl-1,2,3,4-tetrahydrocarbazol-4-one Ondansetron Impurity C Ondansetron Hydrochloride Dihydrate EP Impurity C (USP RC C) 1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOLE-4-ONE 1,2,3,9-TETRAHYDRO-9-METHYL CARBAZOLE-4-ONE 1,2,3,9-TETRAHYDRO-4-OXO-CARBAZOLE 1,2,3,4-TETRAHYDRO-9METHYL-4H-CARBAZOLE-4-ONE 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One99% N-Methylcarbazolone 1,2,3,4-tetrahydro-4-oxocarbazolt 1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONEONDANSETRON 1,2,3,9-Tetrahydro-9-Methyl-4H 1,2,3,4-TETRAHYDRO-9-METHCARBAZOL-4-ONE 1,2,3,9-Tetrahydro-4H-9-methyl-carbazole-4-one N-METHYL-4-OXO-1,2,3,4-TETRAHYDROCARBAZOLE 9-Methyl-2,3-dihydro-1H-carbazol-4-one Ondansetron HCl EP IMpurity-C (USP RC C) Ondansetron Related CoMpound C Ondansetron impurity C (PhEur) Ondansetron Related Compound C (USP) 9-methyl-2,3-dihydro-1H-carbazol-4(9H)-one Ondansetron EP Impurity C Ondansetron Impurity 3（Ondansetron EP Impurity C） Ondansetron EP Impurity C (Ondansetron USP Related Compound C) 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl- 1,2,3,4-Tetrahydro-9-methyl-4-oxocarbazole 1,2,3,9-Tetrahydro-9-methylcarbazol-4-one 4-Tetrahydro-9-methylcarbazol-4-one Ondansetron EP Impurity C/ Ondansetron Related Compound C 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C)Q: What is 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Q: What is the CAS Number of 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Q: What is the storage condition of 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Q: What are the applications of 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Ondansetron Related Compound C (1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one) (1478618) Ondansetron Hydrochloride Dihydrate EP Impurity C Ondansetron USP Related Compound C 1,2,3,9-TETRA HYDRO-9-METHYL-4(H)-CARBAZOL-4-ONE/MCZ Ondansetron Related Compound C (30 mg) (9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one) ONDANSETRON EP IMP C 2,3, - dihydro -9-methyl -1H-carbazol – 4(9H) - one Ondansetron EP Impurity C 9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one 27397-31-1，27397-31-1，Ondansetron Related Compound C 1,2,3,9-Tetrahydro-9-methyl-4H-carbazole-4-one (Ondansetron Impurity) 1,2,3,4-tetrahydro-9-methyl-4H-carbazole ketone 27387-31-1 27397-31-1 C13H15NO Aromatics Heterocycles Impurities Intermediates