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1,2,3,4-Tetrahydro-9-methylcarbazol-4-one

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one structure

CAS No.: 27387-31-1

Chemical Name:: 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one

Synonyms: N-Methylcarbazolone;ONDANSETRON EP IMP C;Ondansetron Impurity C;Ondansetron EP Impurity C;1,2,3,9-Tetrahydro-9-Methyl-4H;Ondansetron Related CoMpound C;Ondansetron impurity C (PhEur);1,2,3,4-tetrahydro-4-oxocarbazolt;1,2,3,9-TETRAHYDRO-4-OXO-CARBAZOLE;Ondansetron USP Related Compound C

CBNumber:: CB2441827

Molecular Formula:: C13H13NO

Molecular Weight:: 199.25

MDL Number:: MFCD00173748

MOL File:: 27387-31-1.mol

Last updated:2025-07-24 18:13:53

Product description	Number	Pack Size	Price
Ondansetron Related Compound C Pharmaceutical Secondary Standard; Certified Reference Material	PHR2224	100mg	$389.5
Ondansetron Related Compound C United States Pharmacopeia (USP) Reference Standard	1478618	30mg	$1360
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one >98.0%(GC)	T2942	5g	$31
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one >98.0%(GC)	T2942	25g	$142
1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one	T293920	1g	$305
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1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Properties

Melting point	199.0 to 203.0 °C
Boiling point	383.5±11.0 °C(Predicted)
Density	1.21±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
form	solid
color	White to Light yellow
BRN	153862
InChI	InChI=1S/C13H13NO/c1-14-10-6-3-2-5-9(10)13-11(14)7-4-8-12(13)15/h2-3,5-6H,4,7-8H2,1H3
InChIKey	HHJUJCWZKJMCLC-UHFFFAOYSA-N
SMILES	N1(C)C2=C(C=CC=C2)C2=C1CCCC2=O
CAS DataBase Reference	27387-31-1(CAS DataBase Reference)
FDA UNII	267IW42T7Z
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301-H412
Precautionary statements	P264-P270-P273-P301+P310-P405-P501
Hazard Codes	Xi,T
Risk Statements	36/37/38-52/53-25
Safety Statements	22-24/25-61-45
RIDADR	UN 2811 6.1 / PGIII
HS Code	2933998090

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2224	Ondansetron Related Compound C Pharmaceutical Secondary Standard; Certified Reference Material	27387-31-1	100mg	$389.5	2025-07-31	Buy
Sigma-Aldrich	1478618	Ondansetron Related Compound C United States Pharmacopeia (USP) Reference Standard	27387-31-1	30mg	$1360	2025-07-31	Buy
TCI Chemical	T2942	1,2,3,4-Tetrahydro-9-methylcarbazol-4-one >98.0%(GC)	27387-31-1	5g	$31	2025-07-31	Buy
TCI Chemical	T2942	1,2,3,4-Tetrahydro-9-methylcarbazol-4-one >98.0%(GC)	27387-31-1	25g	$142	2025-07-31	Buy
TRC	T293920	1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one	27387-31-1	1g	$305	2021-12-16	Buy

Product number	Packaging	Price	Buy
PHR2224	100mg	$389.5	Buy
1478618	30mg	$1360	Buy
T2942	5g	$31	Buy
T2942	25g	$142	Buy
T293920	1g	$305	Buy

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Chemical Properties,Uses,Production

Chemical Properties

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one is Off-White Solid

Uses

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one is used in the preparation of 5-HT3 modulators useful in the treatment and prevention of 5-HT3 receptor-mediated diseases. 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one is an impurity of Ondansetron (O655000).

Synthesis

15128-52-6

4637-24-5

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one

27387-31-1

The reaction was carried out in N,N-dimethylformamide (5.0 mL) at reflux for 1.0 h with 2,3-dihydro-1H-carbazol-4(9H)-one (1.0 mmol) and N,N-dimethylformamide dimethyl acetal (10 mmol). After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (2 x 25 mL). The organic layer was separated and washed with saturated brine solution and subsequently dried over anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure and the resulting solid was recrystallized from ethanol to give white acicular crystals in 71% yield, melting point 188-190 °C. IR (cm-1 ): 1695 (C=O). 1H NMR (400 MHz, CDCl3) δ: 2.24-2.27 (t, 2H, CH2, J = 6.28 Hz), 2.56-2.59 (t, 2H, CH2, J = 6.0 Hz), 2.56-2.59 (t, 2H, CH2, J = 6.0 Hz). CH2, J = 6.0 Hz), 2.91-2.94 (t, 2H, CH2, J = 6.21 Hz), 3.70 (s, 3H, NCH3), 7.27-7.30 (m, 3H, Ph), 8.24-8.26 (m, 1H, Ph). Calculated elemental analysis (C13H13NO): C, 78.36; H, 6.58; N, 7.03%. Measured values: C, 78.29; H, 6.49; N, 6.92%.

References

[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014, vol. 53B, # 12, p. 1606 - 1610
[2] Journal of Molecular Structure, 2014, vol. 1080, p. 137 - 144
[3] Russian Chemical Bulletin, 2005, vol. 54, # 8, p. 1887 - 1891

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one synthesis

Synthesis of 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one from 1,2,3,9-Tetrahydro-4(H)-carbazol-4-one and N,N-Dimethylformamide dimethyl acetal

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Preparation Products And Raw materials

Raw materials

Acrylic acid Phenylhydrazine 1,2,3,9-Tetrahydro-4(H)-carbazol-4-one N,N-Dimethylformamide dimethyl acetal

Preparation Products

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Suppliers

Global( 310)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1087@dideu.com	China	3979	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9297	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21618	55
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58

Supplier	Advantage
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Henan Aochuang Chemical Co.,Ltd.	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hubei Jusheng Technology Co.,Ltd.	58
HubeiwidelychemicaltechnologyCo.,Ltd	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-31	1,2,3,4-Tetrahydro-9-methylcarbazol-4-one 27387-31-1	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2025-07-25	1,2,3,4-Tetrahydro-9-methylcarbazol-4-one 27387-31-1	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-04-27	1,2,3,4-Tetrahydro-9-methylcarbazol-4-one 27387-31-1	US $0.00-0.00 / KG	0.1KG	99%	200tons	Shaanxi Dideu Medichem Co. Ltd

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
27387-31-1
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
27387-31-1
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
27387-31-1
US $0.00-0.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one Spectrum

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one(27387-31-1)¹HNMR

27387-31-1(1,2,3,4-Tetrahydro-9-methylcarbazol-4-one)Related Search:

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Methyl Ondansetron EP Impurity G 3-[(Dimethylamino)methyl]-9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one

1of4

1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONE 9-METHYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-4-ONE 9-METHYL-1,2,3,9-TETRAHYDRO-CARBAZOL-4-ONE 9-METHYL-1,2,3,9-TETRAHYDRO-4H-CARBAZOL-4-ONE 9-METHYL-1,2,3,4-TETRAHYDRO-4-OXOCARBAZOLE 9-METHYL-1,2.3,4-TETRAHYDRO-4-OXOCARBAZOLE-4-ONE Ondansetron EP Impurity C (USP RC C) 1,2,3,4a,9,9a‐Hexahydro‐9‐ methyl‐4H‐carbazol‐4‐one 9-Methyl-1,2,3,4-tetrahydrocarbazol-4-one Ondansetron Impurity C Ondansetron Hydrochloride Dihydrate EP Impurity C (USP RC C) 1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOLE-4-ONE 1,2,3,9-TETRAHYDRO-9-METHYL CARBAZOLE-4-ONE 1,2,3,9-TETRAHYDRO-4-OXO-CARBAZOLE 1,2,3,4-TETRAHYDRO-9METHYL-4H-CARBAZOLE-4-ONE 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One99% N-Methylcarbazolone 1,2,3,4-tetrahydro-4-oxocarbazolt 1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONEONDANSETRON 1,2,3,9-Tetrahydro-9-Methyl-4H 1,2,3,4-TETRAHYDRO-9-METHCARBAZOL-4-ONE 1,2,3,9-Tetrahydro-4H-9-methyl-carbazole-4-one N-METHYL-4-OXO-1,2,3,4-TETRAHYDROCARBAZOLE 9-Methyl-2,3-dihydro-1H-carbazol-4-one Ondansetron HCl EP IMpurity-C (USP RC C) Ondansetron Related CoMpound C Ondansetron impurity C (PhEur) Ondansetron Related Compound C (USP) 9-methyl-2,3-dihydro-1H-carbazol-4(9H)-one Ondansetron EP Impurity C Ondansetron Impurity 3（Ondansetron EP Impurity C） Ondansetron EP Impurity C (Ondansetron USP Related Compound C) 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl- 1,2,3,4-Tetrahydro-9-methyl-4-oxocarbazole 1,2,3,9-Tetrahydro-9-methylcarbazol-4-one 4-Tetrahydro-9-methylcarbazol-4-one Ondansetron EP Impurity C/ Ondansetron Related Compound C 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C)Q: What is 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Q: What is the CAS Number of 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Q: What is the storage condition of 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Q: What are the applications of 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron Related Compound-C) Ondansetron Related Compound C (1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one) (1478618) Ondansetron Hydrochloride Dihydrate EP Impurity C Ondansetron USP Related Compound C 1,2,3,9-TETRA HYDRO-9-METHYL-4(H)-CARBAZOL-4-ONE/MCZ Ondansetron Related Compound C (30 mg) (9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one) ONDANSETRON EP IMP C 2,3, - dihydro -9-methyl -1H-carbazol – 4(9H) - one Ondansetron EP Impurity C 9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one 27387-31-1 27397-31-1 C13H15NO Aromatics Heterocycles Impurities Intermediates