Perfluorotributylamine
- CAS No.
- 311-89-7
- Chemical Name:
- Perfluorotributylamine
- Synonyms
- FC-43;PFTB;PFTBA;FLUORINERT;FLUORINERT FC-43;HEPTACOSAFLUOROTRIBUTYLAMINE;Tris(perfluorobutyl)amine;(n-C4F9)3N;Perfluoro-compound;FLUORINERT(R) FC-43
- CBNumber:
- CB2449979
- Molecular Formula:
- C12F27N
- Molecular Weight:
- 671.09
- MDL Number:
- MFCD00000436
- MOL File:
- 311-89-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -52 °C |
|---|---|
| Boiling point | 178 °C(lit.) |
| Density | 1.883 g/mL at 25 °C(lit.) |
| vapor density | 23.3 (vs air) |
| vapor pressure | 1.3 mm Hg ( 25 °C) |
| refractive index |
n |
| Flash point | None |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| pka | -26.84±0.50(Predicted) |
| form | liquid |
| color | Clear colorless |
| Specific Gravity | 1.880 |
| Water Solubility | insoluble |
| FreezingPoint | -60℃ |
| Specific Heat Capacity | Cp(liquid): 0.62 J/(g·K), at 25℃ |
| BRN | 1813883 |
| Henry's Law Constant | 1.8×10-10 mol/(m3Pa) at 25℃, HSDB (2015) |
| Dielectric constant | 1.8999999999999999 |
| Major Application | environmental |
| InChI | 1S/C12F27N/c13-1(14,7(25,26)27)4(19,20)10(34,35)40(11(36,37)5(21,22)2(15,16)8(28,29)30)12(38,39)6(23,24)3(17,18)9(31,32)33 |
| InChIKey | VUMYZTYYVRXVJA-UHFFFAOYSA-N |
| SMILES | FC(F)(F)C(F)(F)C(F)(F)C(F)(F)N(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F |
| CAS DataBase Reference | 311-89-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 3702Y1HQ6O |
| NIST Chemistry Reference | Perfluorotributylamine(311-89-7) |
| EPA Substance Registry System | 1-Butanamine, 1,1,2,2,3,3,4,4,4-nonafluoro-N,N-bis(1,1,2,2,3,3,4,4,4-nonafluorobutyl)- (311-89-7) |
| UNSPSC Code | 77101502 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P304+P340-P405-P501a-P261-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | YA1000000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29211990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazardous Substances Data | 311-89-7(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
Perfluorotributylamine price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H5262 | Heptacosafluorotributylamine liquid | 311-89-7 | 5ml | $115 | 2026-04-30 | Buy |
| Sigma-Aldrich | 77299 | Heptacosafluorotributylamine analytical standard, for mass spectrometry | 311-89-7 | 5ml | $78.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 77299 | Heptacosafluorotributylamine analytical standard, for mass spectrometry | 311-89-7 | 25mL | $353 | 2026-04-30 | Buy |
| Sigma-Aldrich | 442747-U | Perfluorotributylamine (PFTBA) analytical standard | 311-89-7 | 1000mg | $70 | 2026-04-30 | Buy |
| TCI Chemical | P0074 | Heptacosafluorotributylamine [for Mass spectrometry] min. 60.0 % | 311-89-7 | 5G | $28 | 2026-04-30 | Buy |
Perfluorotributylamine Chemical Properties,Uses,Production
Description
Perfluorotributylamine (PFTBA, also termed FC-43) is a common mass calibrant used in GC-MS systems. It is a dense, moderately high-boiling liquid. It is the main component of Fluosol-43, an artificial blood substitute that has been approved by the US Food and Drug Administration for use in cardiac angioplasty.
PFTBA is also used as an ingredient in some refrigerants. It is persistent in the atmosphere and a powerful greenhouse gas. In 2013, S. A. Mabury at the University of Toronto used IR spectroscopy data to calculate that PFTBA is the strongest global-warming potential of any compound detected in the atmosphere-7100 times greater than that of CO2.
Chemical Properties
clear colourless liquid
Uses
Perfluorotributylamine is used in electronic applications viz. liquid burn-in, testing and vapor phase soldering processes. It acts as an indicator fluid to check the leakage and heat transfer fluid for thermal shock testing. It is an active component in fluosol, which is a substitute for artificial blood and fluorinert coolant liquids. Further, it is used as a solvent for computer disc drive lubrication. In addition to this, it is used as a calibration chemical in gas chromatography.
Perfluorotributylamine (PFTBA) is commonly used for the calibration of the mass axes of mass spectrometers, basically in those systems, which use electron ionization (EI). PFTBA may be used as a calibration standard for the gas chromatography-mass spectrometric determination of tramadol in human plasma samples and phthalate esters in water samples.
Definition
ChEBI: Perfluorotributylamine is an organofluorine compound that is tributylamine in which all the hydrogens have been replaced by fluorine atoms. It has a role as a member of greenhouse gas, a solvent and a blood substitute. It derives from a tributylamine.
Preparation
Perfluorotributylamine (PFTBA) is prepared by electrofluorination of tributylamine using hydrogen fluoride as solvent and source of fluorine: N(C4H9)3 + 27 HF → N(C4F9)3+ 27 H2
Application
Perfluorotributylamine (PFTBA) is commonly used in systems that use electron ionisation (EI) for the calibration of mass spectrometer mass spectrometer mass spectrometer axes, and PFTBA can be used as a calibration standard for the determination of tramadol in human plasma samples by gas chromatography-mass spectrometry (GC-MS), and for the determination of phthalate esters in water samples.
General Description
Perfluorotributylamine (PFTBA) is a perfluoroalkyl amine characterized as a long-lived greenhouse gas with high radiative efficiency, extremely low water solubility, and relatively high volatility[2-3]. PFTBA serves as an absorbent solvent to isolate low-boiling fluorocarbon by-products from electrolysis gases[1]. In biomedical applications, PFTBA is loaded into polydopamine-coated UiO-66 metal-organic framework nanoparticles alongside tirapazamine for hypoxia-activated osteosarcoma therapy[4].
Safety
Perfluorotributylamine is belongs to fluorofluids, fluorofluids are generally of very low toxicity, so much that they have been evaluated as synthetic blood.
Precautions
Store in a cool place. Incompatible with powdered metals and alkali metals.
References
[1] Innovation in the synthesis of perfluorinated organics through electrochemical fluorination in anhydrous liquid hydrogen fluoride: peculiarities of the method and applications of perfluorinated organics. http://notes.fluorine1.ru/contents/history/2003/6_2003/letters/index.html
[2]
Hong, A. C., Young, C. J., Hurley, M. D., Wallington, T. J., Mabury, S. A. (2013). Perfluorotributylamine: A novel long-lived greenhouse gas. Geophysical Research Letters, 40(22), 6010–6015. https://doi.org/10.1002/2013gl058010
[3]
Tsai, W.-T. (2015). Environmental implications of perfluorotributylamine—a potent greenhouse gas. Mitigation and Adaptation Strategies for Global Change, 22(2), 225–231. https://doi.org/10.1007/s11027-015-9684-6
[4]
Chen, H., Fu, Y., Feng, K., Zhou, Y., Wang, X., Huang, H., Chen, Y., Wang, W., Xu, Y., Tian, H., Mao, Y., Wang, J., Zhang, Z. (2021). Polydopamine-coated UiO-66 nanoparticles loaded with perfluorotributylamine/tirapazamine for hypoxia-activated osteosarcoma therapy. Journal of Nanobiotechnology, 19(1). https://doi.org/10.1186/s12951-021-01013-0
Perfluorotributylamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| JIANGXI TIME PHARMACEUTICAL CO.,LTD | 0794-7183888 13155888520 | sales@groupchem.com | China | 50 | 60 |
| Wuhan lanabai Pharmaceutical Chemical Co., Ltd | 027-81819291; 15307151931 | 2355680@qq.com | China | 5634 | 58 |
| Shangfluoro | 021-65170832 15601903708 | qinba_2@163.com | China | 317 | 58 |
| wuhan Bright Chemical Co.,Ltd | +86-027-85583407 +86-13554014698 | purchase_peng@brightchemical.com.cn | China | 63 | 58 |
| Wuhan Silworld Chemical Co.,Ltd | 027-85613400 18707177243 | info@silworldchemical.com | China | 292 | 58 |
| Wuhan kemike Biomedical Technology Co., Ltd | 027-87747081 18186681184 | 1344475572@qq.com | China | 6978 | 58 |
| Shenzhen Xingkaiyue Biotechnology Co. , Ltd. | 0755-18589069862 18589069862 | 1158168052@qq.com | China | 1000 | 58 |
| Wuhan Huaxiang Kejie Biotechnology Co., Ltd | 027-86638848 18627828293 | 3507625507@qq.com | China | 1530 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
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View Lastest Price from Perfluorotributylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-13 | Perfluorotributylamine
311-89-7
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-02 | Perfluorotributylamine
311-89-7
|
$5.00-8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | Perfluorotributylamine
311-89-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- Perfluorotributylamine
311-89-7
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Perfluorotributylamine
311-89-7
- $5.00-8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Perfluorotributylamine
311-89-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
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