Nonafluorobutanesulfonyl fluoride
- CAS No.
- 375-72-4
- Chemical Name:
- Nonafluorobutanesulfonyl fluoride
- Synonyms
- PBSF;1,1,2,2,3,3,4,4,4-Nonafluorobutane-1-sulfonyl fluoride;PERFLUOROBUTANESULFONYL FLUORIDE;PERFLUORO-1-BUTANESULFONYL FLUORIDE;FC-4;Perfluoro n-butylsulfonyl fluoride;Nonafluorobutane-1-sulfonyl fluoride;Nonaflylfluoride;FX-4;50KGS/DRUM
- CBNumber:
- CB3208090
- Molecular Formula:
- C4F10O2S
- Molecular Weight:
- 302.09
- MDL Number:
- MFCD00007422
- MOL File:
- 375-72-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -110°C |
|---|---|
| Boiling point | 64 °C (lit.) |
| Density | 1.682 g/mL at 25 °C (lit.) |
| vapor pressure | 16.665kPa at 20℃ |
| refractive index |
n |
| Flash point | 65-66°C |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Sparingly), Methanol (Sparingly) |
| form | Liquid |
| color | Colorless to yellow |
| Specific Gravity | 1.682 |
| Water Solubility | Hydrolyses in water. |
| Sensitive | Moisture Sensitive |
| BRN | 1813589 |
| Stability | Hygroscopic |
| InChI | 1S/C4F10O2S/c5-1(6,3(9,10)11)2(7,8)4(12,13)17(14,15)16 |
| InChIKey | LUYQYZLEHLTPBH-UHFFFAOYSA-N |
| SMILES | FC(F)(F)C(F)(F)C(F)(F)C(F)(F)S(F)(=O)=O |
| CAS DataBase Reference | 375-72-4(CAS DataBase Reference) |
| FDA UNII | WC4FPA9BCM |
| NIST Chemistry Reference | Nonafluorobutanesulfonyl fluoride(375-72-4) |
| EPA Substance Registry System | 1-Butanesulfonyl fluoride, 1,1,2,2,3,3,4,4,4-nonafluoro- (375-72-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | |||||||||
| PPE | Faceshields, Gloves, Goggles | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45-25 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| Hazard Note | Corrosive | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29049090 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Nonafluorobutanesulfonyl fluoride price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 319732 | Perfluoro-1-butanesulfonyl fluoride 96% | 375-72-4 | 25g | $109 | 2026-04-30 | Buy |
| Sigma-Aldrich | 319732 | Perfluoro-1-butanesulfonyl fluoride 96% | 375-72-4 | 100g | $213 | 2026-04-30 | Buy |
| TCI Chemical | P1098 | Perfluoro-1-butanesulfonyl Fluoride >93.0%(GC) | 375-72-4 | 25g | $75 | 2026-04-30 | Buy |
| TCI Chemical | P1098 | Perfluoro-1-butanesulfonyl Fluoride >93.0%(GC) | 375-72-4 | 250g | $437 | 2026-04-30 | Buy |
| Usbiological | 285456 | Nonafluoro butanesulfonyl fluoride | 375-72-4 | 5g | $280 | 2026-06-03 | Buy |
Nonafluorobutanesulfonyl fluoride Chemical Properties,Uses,Production
Description
1,1,2,2,3,3,4,4,4-Nonafluorobutane-1-sulfonyl fluoride (NfF) also called Nonafluorobutanesulfonyl fluoride is a versatile compound in organic synthesis. It can be used as a fluoride source for the nucleophilic introduction of fluorine, but it is also frequently applied as sulfonylation reagent generating intermediates with strong electron withdrawing perfluorinated alkyl substituents.
Chemical Properties
Nonafluorobutanesulfonyl fluoride is a colorless, volatile liquid that is immiscible with water but soluble in common organic solvents. It is prepared by the electrochemical fluorination of sulfolane.
Uses
Benzynes were generated from o-(trimethylsilyl) phenols using nonafluorobutanesulfonyl fluoride (NfF) by a domino process.Nonafluorobutanesulfonyl fluoride (nonaflyl fluoride, C 4 F 9 SO 2 F, NfF) is the most widely used commercially available reagent for the synthesis of nonaflates.
Uses
Nonafluorobutanesulfonyl fluoride (NfF, NBSF, PBSF) can be used as a general-purpose diazotransfer reagent with high efficiency, wide substrate range, good shelf stability, relatively low cost, and easy purification. It is a favourable alternative to other commonly used diazotransfer reagents[1]. In addition, Nonafluorobutanesulfonyl fluoride was used in the formation of a new dehydrated glycosylation scheme. In contrast to the main classical glycosylation reactions, this scheme glycosylation reaction is carried out under mildly alkaline conditions. In the absence of an external acceptor, the glycosyl hemiacetal undergoes self-condensation, providing the corresponding symmetric 1,1'- disaccharide in high yield[2].
Application
Perfluoro-1-butanesulfonyl fluoride (NfF) reacts with alcohols, including phenols, to yield nonafluorobutanesulfonate esters (nonaflates). Nonaflates can be used as electrophiles in several palladium-catalyzed cross coupling reactions and in Buchwald-Hartwig amination. NfF can also be used to prepare aryl nonaflates by reacting with corresponding aryloxysilanes in the presence of fluoride ion.
reaction suitability
reaction type: click chemistry
Synthesis
NfF(Nonafluorobutanesulfonyl fluoride) is produced on industrial scale by anodic fluorination of sulfolene (1, Scheme 1),3 therefore it is a fairly cheap reagent and commercially available from several suppliers. The compound is bench-stable and storable for years, nontoxic and easy to handle.
storage
Store in amber colored bottles protected from light; for prolonged storage, PVC bottles are recommended.
References
[1] JOSE LUIS CHIARA; José R S. Synthesis of α-Diazo Carbonyl Compounds with the Shelf-Stable Diazo Transfer Reagent Nonafluorobutanesulfonyl Azide[J]. Advanced Synthesis & Catalysis, 2011. DOI:10.1002/adsc.201000846.
[2] YU TANG; Biao Y; D Prabhakar Reddy. A dehydrative glycosylation protocol mediated by nonafluorobutanesulfonyl fluoride (NfF)[J]. Tetrahedron, 2021. DOI:10.1016/j.tet.2020.131800.
Nonafluorobutanesulfonyl fluoride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Hemao New Material Co., Ltd. | 13061243681 | hemiao66@163.com | China | 182 | 58 |
| wuhan Bright Chemical Co.,Ltd | +86-027-85583407 +86-13554014698 | purchase_peng@brightchemical.com.cn | China | 63 | 58 |
| JIANGXI TIME PHARMACEUTICAL CO.,LTD | 0794-7183888 13155888520 | sales@groupchem.com | China | 50 | 60 |
| Taicang Chemwells Chemical Technology Co., Ltd. | 0512-0512-53202808 15850293895 | johnny@chemwells.com | China | 128 | 58 |
| shanghai sinofluoro chemicals co., ltd. | 15800445152 | sales@sinofluoro.com | China | 298 | 59 |
| West fluorine technology co., ltd | 0531-85906692 15588812394 | 325912682@qq.com | China | 370 | 58 |
| Shangfluoro | 021-65170832 15601903708 | qinba_2@163.com | China | 317 | 58 |
| Shaanxi Weiyu New Materials Co., Ltd | 13772052144 13772052144 | 308828748@qq.com | China | 3000 | 58 |
| HUNAN CHEMFISH SCIENTIFIC CO.,LTD | 85521272 18932438858 | sales@chemfish.com | China | 7780 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
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View Lastest Price from Nonafluorobutanesulfonyl fluoride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Nonafluorobutanesulfonyl fluoride
375-72-4
|
170kg/Drum | 98% | 100 T/Month | Hebei Qujie Technology Co., Ltd. | ||
 |
2026-09-11 | Nonafluorobutanesulfonyl fluoride
375-72-4
|
$2.00 | 1kg | 99% | 500mt | Jinan Finer Chemical Co., Ltd | |
 |
2026-09-11 | Nonafluorobutane Sulfonyl fluoride
375-72-4
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Nonafluorobutanesulfonyl fluoride
375-72-4
- $0.00
- 98%
- Hebei Qujie Technology Co., Ltd.
-
- Nonafluorobutanesulfonyl fluoride
375-72-4
- $2.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Nonafluorobutane Sulfonyl fluoride
375-72-4
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
