Pentadecafluorooctanoic acid
- CAS No.
- 335-67-1
- Chemical Name:
- Pentadecafluorooctanoic acid
- Synonyms
- Pfoa;PERFLUOROOCTANOIC ACID;PERFLUOROOCTANOATE;PERFLUORO-N-OCTANOIC ACID;N-PERFLUOROOCTANOIC ACID;Perfluoroctanoic acid;PERFLUOROCAPRYLIC ACID;Perfluorooctanoic acid(PFOA);2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-PENTADECAFLUOROOCTANOIC ACID;A 5717
- CBNumber:
- CB4256038
- Molecular Formula:
- C8HF15O2
- Molecular Weight:
- 414.07
- MDL Number:
- MFCD00004174
- MOL File:
- 335-67-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 55-56 °C (lit.) |
|---|---|
| Boiling point | 189 °C/736 mmHg (lit.) |
| Density | 1,7 g/cm3 |
| Flash point | 189-192°C |
| storage temp. | 2-8°C |
| solubility | 3.4g/l |
| form | Crystalline Powder |
| pka | 0.50±0.10(Predicted) |
| Specific Gravity | 1.7 |
| color | White |
| PH | 2.6 (1g/l, H2O, 20℃) |
| Water Solubility | 3.4 g/L |
| BRN | 1809678 |
| Henry's Law Constant | 4.9×10-2 mol/(m3Pa) at 25℃, Kutsuna and Hori (2008) |
| Stability | Stable. Incompatible with bases, oxidizing agents, reducing agents. |
| Major Application |
PFAS testing cleaning products cosmetics environmental food and beverages personal care |
| InChI | 1S/C8HF15O2/c9-2(10,1(24)25)3(11,12)4(13,14)5(15,16)6(17,18)7(19,20)8(21,22)23/h(H,24,25) |
| InChIKey | SNGREZUHAYWORS-UHFFFAOYSA-N |
| SMILES | OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F |
| Toxicology and Carcinogenesis | Toxicology and Carcinogenesis Studies of Perfluorooctanoic Acid (CASRN 335-67-1) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Revised) |
| Substances of Very High Concern (SVHC) Candidate List | Pentadecafluorooctanoic acid (PFOA) (335-67-1) |
| CAS DataBase Reference | 335-67-1(CAS DataBase Reference) |
| EWG's Food Scores | 8 |
| FDA UNII | 947VD76D3L |
| Proposition 65 List | Perfluorooctanoic Acid (PFOA) |
| IARC | 2B (Vol. 110) 2017 |
| NIST Chemistry Reference | Octanoic acid, pentadecafluoro-(335-67-1) |
| EPA Substance Registry System | Perfluorooctanoic acid (335-67-1) |
| Toxicological Profile|ATSDR | Pentadecafluorooctanoic acid|Toxicological Profile|ATSDR |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H332-H318-H351-H360D-H362-H372 | |||||||||
| Precautionary statements | P260-P263-P280-P304+P340+P312-P305+P351+P338-P308+P313 | |||||||||
| target organs | Eyes,Central nervous system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C,Xi,T,F | |||||||||
| Risk Statements | 22-34-52/53-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 26-36/37/39-45-36/37-16-7 | |||||||||
| RIDADR | UN 3261 8/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | RH0781000 | |||||||||
| Hazard Note | Corrosive | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29159080 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1 |
|||||||||
| Hazardous Substances Data | 335-67-1(Hazardous Substances Data) | |||||||||
| Toxicity | dnd-esc 50 mmol MUREAV 89,95,81 | |||||||||
| NFPA 704 |
|
Pentadecafluorooctanoic acid price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 171468 | Perfluorooctanoic acid 96% | 335-67-1 | 5g | $47.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 171468 | Perfluorooctanoic acid 96% | 335-67-1 | 25g | $158 | 2026-04-30 | Buy |
| TCI Chemical | A5717 | Pentadecafluorooctanoic Acid (ca. 5mmol)[Ion-Pair Reagent for LC-MS] >98.0%(T) | 335-67-1 | 1sample | $77 | 2023-06-20 | Buy |
| TCI Chemical | A5720 | Pentadecafluorooctanoic Acid High Grade [Ion-Pair Reagent for LC-MS] >98.0%(T) | 335-67-1 | 1g | $76 | 2021-12-16 | Buy |
| Cayman Chemical | 37232 | Pentadecafluorooctanoic Acid | 335-67-1 | 5g | $44 | 2026-04-30 | Buy |
Pentadecafluorooctanoic acid Chemical Properties, Uses, Production
Description
Concerns about the potential environmental and toxicological impacts of long-chain perfluoroalkyl sulfonates and carboxylic acids have led to: (1) the phaseout of production of perfluorooctane sulfonate (PFOS) and related compounds and perfluorooctanoic acid (PFOA) by their major global manufacturer in 2000–02; (2) the conclusion of a stewardship agreement between the United States Environmental Protection Agency (US EPA) and eight leading global companies to reduce emissions and product content of PFOA and related chemicals by 95% by 2010 and to work toward their elimination by 2015; (3) a similar agreement between the Canadian environmental and health authorities and five companies to restrict perfluorinated carboxylic acids in products; (4) a European Union Marketing and Use Directive restricting the use of ‘PFOSs’ in the European Union; and (5) the inclusion of PFOS in the Stockholm Convention on Persistent Organic Pollutants as an Annex B substance, i.e., restricted in its use; and other regulatory and voluntary initiatives intended to reduce environmental emissions of this family of compounds.
Chemical Properties
Perfluorooctanoic acid is a white to off-white powder or colorless flakes. It is very soluble in water.It has a pH of 2.6. Perfluorooctanoic acid has the ability to react with bases, oxidizing agents, and reducing agents. Upon decomposition, PFOA can form carbon oxides and hydrogen fluoride. Additional information related to physical and chemical properties of PFOA are not currently available.
Uses
Perfluorooctanoic acid (PFOA) is fluorinated surfactant used, primarily as its ammonium salt (APFO), as an aid in the chemical synthesis of fluoropolymers and fluoroelastomers. As such, it may be found in nonstick cookware and utensils, stain-repellant fabric treatments, and water-proofing treatments for garments. Although an effort is underway by the U.S. EPA to reduce use of and replace perfluoroalkyls with other substances, PFOA is still used in United States industry.
Perfluorooctanoic acid (PFOA, C8, pentadecafluorooctanoic acid, perfluoro caprylic acid) is an eightcarbon compound in the perfluoroalkyl family of chemicals. Perfluorooctane sulfonate is used in a variety of applications, including nonstick cookware, waterproof clothing, leather products, cleaning products, and pesticides. Its main use was as a stain repellent on carpet, furniture, and other consumer products. In 2006, the U.S. Protection Agency along with eight major companies that utilized PFOA embarked on a program to reduce emissions and use of the chemical by 2015 (USEPA, 2012).
Uses
PFOA is a completely fluorinated organic acid that is produced synthetically as its salts. The typical structure has a nonbranched chain of eight carbon atoms. The industrial production of perfluoroalkyl carboxylates started in the late 1940s. Two principal production processes are used to manufacture PFOA, viz. electrochemical fluorination and telomerization. PFOA can also appear as a result of degradation of some precursors, e.g., fluorotelomer alcohols. The ammonium salt of PFOA is primarily used as an emulsifier or ‘processing aid’ in industrial applications, for example, in the production of fluoropolymers such as polytetrafluoroethylene, but also produced for fluorosurfactant use. Typical uses include fluoropolymers in electronics, textiles, and nonstick cookware, and fluorosurfactants in aqueous filmforming foams used for fire fighting.
Uses
Pentadecafluorooctanoic acid solution may be used as an ion-pairing reagent in the development of a chromatographic method for the separation and determination of underivatized proteinic amino acids using liquid chromatography with evaporative light scattering detection (LC-ELSD) and atmospheric pressure ionization-mass spectrometry (LC-API-MS), respectively.
Definition
ChEBI: A fluoroalkanoic acid that is perfluorinated octanoic acid.
General Description
Perfluorooctanoic acid is a perfluoroalkyl acid commonly used in the preparation of fluoroacrylic esters, fluoropolymers and fluoroelastmers. It is found to be environmentally persistent and bioaccumulative with a long half-life.
Safety Profile
Poison by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits toxic vapors of Fí.
Environmental Fate
Perfluorooctanoic acid found in the environment may result from waste stream releases from manufacture of cosmetics, lubricants, paints, polishes, adhesives, fabric treatments, and fire-fighting compounds. It can partition to the vapor phase in the atmosphere, where it is degraded atmospherically with a half-life of 31 days. It is very resistant to hydrolysis, and immobile in soil. It will not likely evaporate from soil (depending on soil pH) or surface waters. It is not expected to be absorbed to sediments and suspended particles. Perfluorooctanoic acid is not expected to bioaccumulate in aquatic organisms (BCF =3.1–9.4) (NLM, 2013).
Purification Methods
Crystallise the acid from CCl4 and toluene, and distil it. It forms micelles in H2O and the solubility is 1% in H2O. The acid chloride has b 129-130o/744mm. The amide has m 138o. [Bernett & Zisman J Phys Chem 63 1911 1959, Bro & Sperati J Polym Sci 38 289 1959, Beilstein 2 IV 994.]
Toxicity evaluation
Studies with animals fed PFOA for a long period showed effects
on the stomach, liver, and thyroid hormones. Animal studies
also indicate that PFOA may cause cancer at relatively high
levels. PFOA has also been shown to be a developmental
toxicant, and to have effects on the immune system.
PFOA affects primarily the liver and can cause developmental
and reproductive toxic effects at relatively low dose
levels in experimental animals. It increases the tumor incidence
in rats, mainly in the liver. The carcinogenic effects in rats
appear to be due to indirect/nongenotoxic modes of action.
Epidemiological studies in PFOA-exposed workers do not
indicate an increased cancer risk. There is relatively consistent
evidence of modest positive associations between serum levels
of PFOA and cholesterol, uric acid, and liver enzyme levels.
The critical effects observed in rodents and monkeys are on
the liver and include hypertrophy, changes in liver enzyme
activity, and proliferation of peroxisomes.
In rodents the anionic form of PFOA induces hepatocellular
adenomas, Leydig cell adenomas, and pancreatic hyperplasia.
The genotoxic activity of PFOA is a matter of current debate and
controversy, with classifications as ‘devoid of significant genotoxicity’
as well as ‘weakly nonspecific genotoxic.’ PFOA does
not appear directly genotoxic; animal data indicate that it can
cause several types of tumors and neonatal death and may have
toxic effects on the immune, liver, and endocrine systems.
Toxics Screening Level
The initial threshold screening level (ITSL) for perfluorooctanoic acid (PFOA) is 0.0001 μg/m3 with 24-hour averaging time.
Pentadecafluorooctanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yangzhou modier Electronic Materials Co., Ltd | 13761402923 19975033992 | market@modeltemol.com | China | 7841 | 58 |
| Shanghai Titan Scientific Co.,Ltd | 18616708014 | yhx@titansci.com | China | 9999 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
View Latest Price from Pentadecafluorooctanoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | Pentadecafluorooctanoic acid
335-67-1
|
$1.00-50.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-07-20 | Perfluorooctanoic acid
335-67-1
|
$50.00-128.00 | 99.62% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-28 | Perfluorooctanoic Acid
335-67-1
|
$80.00-100.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Pentadecafluorooctanoic acid
335-67-1
- $1.00-50.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Perfluorooctanoic acid
335-67-1
- $50.00-128.00
- 99.62%
- TargetMol Chemicals Inc.
-
- Perfluorooctanoic Acid
335-67-1
- $80.00-100.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
