4-Phenoxyphenylhydrazine hydrochloride
- CAS No.
- 60481-02-9
- Chemical Name:
- 4-Phenoxyphenylhydrazine hydrochloride
- Synonyms
- N-(4-Phenoxy-phenyl)-hydrazinium;4-Phenoxyphenylhydrazine hydrochloride;1-(4-PHENOXYPHENYL)HYDRAZINE HYDROCHLORIDE;4-Phenoxyphenylhydrazine hydrochloride 95+%;N'-(4-PHENOXY-PHENYL)-HYDRAZINIUM, CHLORIDE
- CBNumber:
- CB2456294
- Molecular Formula:
- C12H13ClN2O
- Molecular Weight:
- 236.7
- MDL Number:
- MFCD03426044
- MOL File:
- 60481-02-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 187-189(dec.) |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | solid |
| color | Brown |
| InChI | 1S/C12H12N2O.ClH/c13-14-10-6-8-12(9-7-10)15-11-4-2-1-3-5-11;/h1-9,14H,13H2;1H |
| InChIKey | BFNBYPAMZTYWBT-UHFFFAOYSA-N |
| SMILES | NNC1=CC=C(C=C1)OC2=CC=CC=C2.Cl |
| CAS DataBase Reference | 60481-02-9(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H318 |
| Precautionary statements | P280-P301+P312+P330-P305+P351+P338+P310 |
| Hazard Codes | Xi |
| WGK Germany | WGK 3 |
| Hazard Note | Irritant |
| HazardClass | IRRITANT, IRRITANT-HARMFUL |
| HS Code | 2928009090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 |
4-Phenoxyphenylhydrazine hydrochloride price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | JRD0815 | 1-(4-Phenoxyphenyl)hydrazine hydrochloride | 60481-02-9 | 1G | $197 | 2026-04-30 | Buy |
| Apolloscientific | OR7923 | 4-Phenoxyphenylhydrazine hydrochloride 95% | 60481-02-9 | 1g | $195 | 2026-06-04 | Buy |
| Apolloscientific | OR7923 | 4-Phenoxyphenylhydrazine hydrochloride 95% | 60481-02-9 | 5g | $583 | 2026-06-04 | Buy |
| Apolloscientific | OR7923 | 4-Phenoxyphenylhydrazine hydrochloride 95% | 60481-02-9 | 25g | $2338 | 2026-06-04 | Buy |
| Activate Scientific | AS47555 | (4-Phenoxyphenyl)hydrazine hydrochloride 97% | 60481-02-9 | 1g | $115 | 2026-06-04 | Buy |
4-Phenoxyphenylhydrazine hydrochloride Chemical Properties, Uses, Production
Synthesis
139-59-3
60481-02-9
The general procedure for the synthesis of 4-phenoxyphenylhydrazine hydrochloride from 4-aminodiphenyl ether is as follows: to a concentrated solution of 4-phenoxyaniline (2 g, 10.8 mmol, 1 equiv). A solution of ice-cold sodium nitrite (1.49 g, 21.6 mmol, 2.0 eq.) in water (7.6 mL) was added dropwise to hydrochloric acid (22 mL) over a period of 15 min while maintaining the reaction temperature below 10 °C. The reaction mixture was cooled to 0 °C and stirred continuously for 1 hour. Subsequently, sulfamic acid (1.05 g, 10.8 mmol, 1 eq.) was added to the reaction mixture in batches over 20 minutes. Next, a concentrated hydrochloric acid solution of tin(II) chloride dihydrate (9.78 g, 43.2 mmol, 4 eq.) was added. Hydrochloric acid (8.2 mL) was added dropwise over a period of 20 minutes while the reaction temperature was controlled to be below 15 °C. The reaction mixture was continued to be stirred at 0 °C for 2 h and then alkalized to pH 14 with 5 M aqueous sodium hydroxide solution, during which the reaction temperature was kept below 30 °C. After completion of the reaction, the reaction mixture was rapidly extracted with dichloromethane (2 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, and the solvent was removed by filtration and vacuum. The unstable (4-phenoxyphenyl) hydrazine was converted to its hydrochloride salt by using an ether (20 mL) solution of 2M hydrochloric acid. The precipitate formed was collected and dried under reduced pressure to give the final 4-phenoxyphenylhydrazine hydrochloride as a light brown solid (1.2 g, 44% yield).
References
[1] European Journal of Medicinal Chemistry, 2012, vol. 58, p. 452 - 463
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 7, p. 3152 - 3162
[3] Patent: CN105061315, 2017, B. Location in patent: Paragraph 0065; 0067
4-Phenoxyphenylhydrazine hydrochloride Preparation Products And Raw materials
4-Phenoxyphenylhydrazine hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai potentpharm CO.,Ltd | 13524892556 | sales-cn@potentpharm.com | China | 1011 | 55 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5855 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
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| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Yantai ShengKailun Chemical Technology Co., Ltd. | 13356901049 | 3119594100@qq.com | China | 7964 | 55 |
View Latest Price from 4-Phenoxyphenylhydrazine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-22 | 4-PHENOXYPHENYLHYDRAZINE HYDROCHLORIDE
60481-02-9
|
$1.00 | 1KG | MIn98%HPLC/LC | 100KGS | Career Henan Chemica Co |
-
- 4-PHENOXYPHENYLHYDRAZINE HYDROCHLORIDE
60481-02-9
- $1.00
- MIn98%HPLC/LC
- Career Henan Chemica Co
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