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2-Amino-4-chloro-6-methylpyrimidine

2-Amino-4-chloro-6-methylpyrimidine structure

CAS No.: 5600-21-5

Chemical Name:: 2-Amino-4-chloro-6-methylpyrimidine

Synonyms: AM;4-CHLORO-6-METHYLPYRIMIDIN-2-AMINE;ACLP;ProAM-N20;prepn. AM;Rhod-4™AKOS MSC-0728;Cal-630™Fura-10™AM (inhibitor)

CBNumber:: CB2458081

Molecular Formula:: C5H6ClN3

Molecular Weight:: 143.57

MDL Number:: MFCD00006091

MOL File:: 5600-21-5.mol

Last updated:2025-07-24 18:13:53

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2-Amino-4-chloro-6-methylpyrimidine Properties

Melting point	183-186 °C (lit.)
Boiling point	234.32°C (rough estimate)
Density	1.2986 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	acetic acid: soluble50mg/mL, clear, colorless to faintly yellow
pka	4.26±0.10(Predicted)
form	Solid
color	White to Off-White
biological source	rabbit
Water Solubility	Insoluble in water.
BRN	114297
InChI	InChI=1S/C5H6ClN3/c1-3-2-4(6)9-5(7)8-3/h2H,1H3,(H2,7,8,9)
InChIKey	NPTGVVKPLWFPPX-UHFFFAOYSA-N
SMILES	C1(N)=NC(C)=CC(Cl)=N1
CAS DataBase Reference	5600-21-5(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	8ZBB1FM476
NIST Chemistry Reference	2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)
UNSPSC Code	12352203
NACRES	NA.41

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H335-H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-20/21/22

Safety Statements

22-24/25-37/39-26-36

WGK Germany

RTECS

UV6329600

HazardClass

IRRITANT, AVOID SKIN CONTACT

HS Code

29335995

NFPA 704

	1
2		0

2-Amino-4-chloro-6-methylpyrimidine price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	122882	2-Amino-4-chloro-6-methylpyrimidine 97%	5600-21-5	5g	$23.38	2025-07-31	Buy
Sigma-Aldrich	SAB1303888	ANTI-ADM (CENTER) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution		400 μL	$496	2025-07-31	Buy
Sigma-Aldrich	122882	2-Amino-4-chloro-6-methylpyrimidine 97%	5600-21-5	25g	$88.9	2025-07-31	Buy
TCI Chemical	A1088	2-Amino-4-chloro-6-methylpyrimidine >98.0%(T)	5600-21-5	5g	$26	2025-07-31	Buy
TCI Chemical	A1088	2-Amino-4-chloro-6-methylpyrimidine >98.0%(T)	5600-21-5	25g	$76	2025-07-31	Buy

Product number	Packaging	Price	Buy
122882	5g	$23.38	Buy
SAB1303888	400 μL	$496	Buy
122882	25g	$88.9	Buy
A1088	5g	$26	Buy
A1088	25g	$76	Buy

2-Amino-4-chloro-6-methylpyrimidine Chemical Properties,Uses,Production

Chemical Properties

WHITE TO LIGHT YELLOW NEEDLE-LIKE CRYST. POWDER

Uses

2-Amino-4-chloro-6-methylpyrimidine was used to study the influence of chlorine substitution in pyrimidine ring on proton donor ability of amino group in 2-aminopyrimidine.

Definition

ChEBI: An aminopyrimidine compound having its amino group at position 2 and chloro and methyl substituents at positions 4 and 6 respectively.

General Description

2-Amino-4-chloro-6-methylpyrimidine is a nitification inhibitor.

Synthesis

3977-29-5

5600-21-5

General procedure for the synthesis of 2-amino-4-chloro-6-methylpyrimidine from 2-amino-4-hydroxy-6-methylpyrimidine: 6 g of 2-amino-4-hydroxy-6-methylpyrimidine (IV) was mixed with 35 mL of freshly distilled phosphorous trichloride and the reaction was carried out by refluxing the mixture until it was homogeneous. Upon completion of the reaction, the excess phosphorous trichloride was removed under vacuum. The reaction mixture was cooled and the residue was mixed with ice water and the pH was adjusted with 25% ammonia to 8. The resulting suspension was filtered and the precipitate was washed with water. The crude product was recrystallized from 50% ethanol and dried to constant weight at constant temperature. A final 3.7 g of the target product (54% yield) was obtained with a melting point of 188°C (literature value 182-183°C [7]) and a thin-layer chromatographic Rf value of 0.79 (Expander D). Elemental analysis results: 41.74% C, 4.05% H, 29.35% N. Theoretically calculated values for the molecular formula C5H6ClN3: C 41.83%, H 4.21%, N 29.27%.

Purification Methods

Recrystallise it from EtOH. [Beilstein 24 H 84.]

References

[1] Russian Journal of General Chemistry, 2015, vol. 85, # 1, p. 79 - 87
[2] Zhurnal Obshchei Khimii, 2015, vol. 85, # 1, p. 79 - 87,9

2-Amino-4-chloro-6-methylpyrimidine synthesis

Synthesis of 2-Amino-4-chloro-6-methylpyrimidine from 2-Amino-6-methyl-4-pyrimidinol

2-Amino-4-chloro-6-methylpyrimidine Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Sodium Phosphorus oxitrichloride Guanidine hydrochloride Diethyl ether

4-Chloro-2-ethylsulfanyl-6-methyl-pyrimidine 2-Amino-6-methyl-4-pyrimidinol 2-Chloro-6-methylpyrimidin-4-ylamine 2,4-Dichloro-6-methylpyrimidine

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Preparation Products

SGI-1027 2-Amino-4,6-dimethylpyrimidine 2-amino-4-methyl-6-ethylaminopyrimidine 2-AMINO-4-PIPERIDINO-6-METHYLPYRIMIDINE N-(4-chloro-6-methyl-pyrimidin-2-yl)-acetamide

2-Amino-4-chloro-6-methylpyrimidine Suppliers

Global( 395)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20195	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29733	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49730	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58

View Lastest Price from 2-Amino-4-chloro-6-methylpyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-01-02	4-Chloro-6-methyl-2-pyrimidinamine 5600-21-5	US $200.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2022-04-22	2-amino-4-chloro-6-methylpyrimidine 5600-21-5	US $0.00-0.00 / kg	0.0001kg	98%min	100kgs/month	Shanghai Rlavie Technology Co ltd
2022-02-25	4-Chloro-6-methyl-2-pyrimidinamine 5600-21-5	US $9.90 / Kg/Bag	1KG	99%	10kg	Hong Kong Tiansheng New Material Trading Co., Ltd

4-Chloro-6-methyl-2-pyrimidinamine
5600-21-5
US $200.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

2-amino-4-chloro-6-methylpyrimidine
5600-21-5
US $0.00-0.00 / kg
98%min
Shanghai Rlavie Technology Co ltd

4-Chloro-6-methyl-2-pyrimidinamine
5600-21-5
US $9.90 / Kg/Bag
99%
Hong Kong Tiansheng New Material Trading Co., Ltd

2-Amino-4-chloro-6-methylpyrimidine Spectrum

2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)MS 2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)¹HNMR 2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)¹³CNMR 2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)IR1 2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)IR2 2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)Raman

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TIMTEC-BB SBB004134 2-amino-4-chloro-6-methyl-pyrimidin 2-Pyrimidinamine, 4-chloro-6-methyl- 2-AMINO-4-CHLORO-6-METHYLPYRIMIDINE (ACLP) 2-Amino-4-chloro-6-methylpyrimidine ,97% 4-Chloro-6-methyl-pyrimidine-2-amine 2-Amino-4-chloro-6-methylpyrimidine,98% AMR human cell line ANTI-ADM (CENTER) antibody produced in rabbit Proadrenomedullin N-20 terminal peptide ProAM N-terminal 20 peptide ProAM-N20 2-AMINO-4-CHLORO-6-METHYLPYRIMIDINE 2-AMINO-4-CHLORO-6-METHYL-PYRIMIDINE*CRY STALLINE Amino-4-chloro-6-methylpyrimidine 2-Pyrimidinamine, 4-chloro-6-methyl- (9CI) 2-amino-4-chloro-methoxypyrimidine 4-chloro-6-methyl-2-pyrimidinamin 4-Chloro-6-methyl-2-pyrimidinamine 4-CHLORO-6-METHYLPYRIMIDIN-2-AMINE 4-CHLORO-6-METHYL-PYRIMIDIN-2-YLAMINE 4-CHLORO-6-METHYL-2-PYRIMIDINYLAMINE AKOS MSC-0728 ACLP AM AM (inhibitor) AM (Nitrification inhibitor) AM (pesticide) am(nitrificationinhibitor) prepn. AM Pyrimidine, 2-amino-4-chloro-6-methyl- ASISCHEM C58325 4-Chloro-6-methyl-pyrimidinamine 2-Amino-4-chloro-6-methylpyrimidine > 2-Amino-4-chloro-6-methylpyrimidine ISO 9001：2015 REACH Cal-630&trade Fura-8FF&trade Rhod-4&trade Fura-10&trade 5600-21-5 C5H6N3Cl HETERO CHLORIDE Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyrimidines PYRIMIDINE Heterocycle-Pyrimidine series Pyrazines, Pyrimidines & Pyridazines Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrimidinesHeterocyclic Building Blocks Amines Pyrazines, Pyrimidines & Pyridazines Pyrimidines FINE Chemical & INTERMEDIATES Fluorobenzene