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2-Amino-4-chloro-6-methylpyrimidine

2-Amino-4-chloro-6-methylpyrimidine Structure
2-Amino-4-chloro-6-methylpyrimidine structure
CAS No.
5600-21-5
Chemical Name:
2-Amino-4-chloro-6-methylpyrimidine
Synonyms
AM;4-CHLORO-6-METHYLPYRIMIDIN-2-AMINE;ACLP;ProAM-N20;prepn. AM;Rhod-4™AKOS MSC-0728;Cal-630™Fura-10™AM (inhibitor)
CBNumber:
CB2458081
Molecular Formula:
C5H6ClN3
Molecular Weight:
143.57
MDL Number:
MFCD00006091
MOL File:
5600-21-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:29:22
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2-Amino-4-chloro-6-methylpyrimidine Properties

Melting point 183-186 °C (lit.)
Boiling point 234.32°C (rough estimate)
Density 1.2986 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility acetic acid: soluble50mg/mL, clear, colorless to faintly yellow
pka 4.26±0.10(Predicted)
form Solid
color White to Off-White
biological source rabbit
Water Solubility Insoluble in water.
BRN 114297
InChI InChI=1S/C5H6ClN3/c1-3-2-4(6)9-5(7)8-3/h2H,1H3,(H2,7,8,9)
InChIKey NPTGVVKPLWFPPX-UHFFFAOYSA-N
SMILES C1(N)=NC(C)=CC(Cl)=N1
CAS DataBase Reference 5600-21-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 8ZBB1FM476
NIST Chemistry Reference 2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)
UNSPSC Code 12352203
NACRES NA.41

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  22-24/25-37/39-26-36
WGK Germany  3
RTECS  UV6329600
HazardClass  IRRITANT, AVOID SKIN CONTACT
HS Code  29335995
Storage Class 11 - Combustible Solids
NFPA 704
1
2 0

2-Amino-4-chloro-6-methylpyrimidine price More Price(68)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 122882 2-Amino-4-chloro-6-methylpyrimidine 97% 5600-21-5 5g $35.6 2026-04-30 Buy
Sigma-Aldrich 122882 2-Amino-4-chloro-6-methylpyrimidine 97% 5600-21-5 25g $135 2026-04-30 Buy
Sigma-Aldrich SAB1303888 ANTI-ADM (CENTER) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution 400 μL $496 2025-07-31 Buy
TCI Chemical A1088 2-Amino-4-chloro-6-methylpyrimidine >98.0%(T) 5600-21-5 5g $24 2026-04-30 Buy
TCI Chemical A1088 2-Amino-4-chloro-6-methylpyrimidine >98.0%(T) 5600-21-5 25g $71 2026-04-30 Buy
Product number Packaging Price Buy
122882 5g $35.6 Buy
122882 25g $135 Buy
SAB1303888 400 μL $496 Buy
A1088 5g $24 Buy
A1088 25g $71 Buy

2-Amino-4-chloro-6-methylpyrimidine Chemical Properties, Uses, Production

Chemical Properties

WHITE TO LIGHT YELLOW NEEDLE-LIKE CRYST. POWDER

Uses

2-Amino-4-chloro-6-methylpyrimidine was used to study the influence of chlorine substitution in pyrimidine ring on proton donor ability of amino group in 2-aminopyrimidine.

Definition

ChEBI: An aminopyrimidine compound having its amino group at position 2 and chloro and methyl substituents at positions 4 and 6 respectively.

General Description

2-Amino-4-chloro-6-methylpyrimidine is a nitification inhibitor.

Synthesis

2-Amino-6-methyl-4-pyrimidinol

3977-29-5

2-Amino-4-chloro-6-methylpyrimidine

5600-21-5

General procedure for the synthesis of 2-amino-4-chloro-6-methylpyrimidine from 2-amino-4-hydroxy-6-methylpyrimidine: 6 g of 2-amino-4-hydroxy-6-methylpyrimidine (IV) was mixed with 35 mL of freshly distilled phosphorous trichloride and the reaction was carried out by refluxing the mixture until it was homogeneous. Upon completion of the reaction, the excess phosphorous trichloride was removed under vacuum. The reaction mixture was cooled and the residue was mixed with ice water and the pH was adjusted with 25% ammonia to 8. The resulting suspension was filtered and the precipitate was washed with water. The crude product was recrystallized from 50% ethanol and dried to constant weight at constant temperature. A final 3.7 g of the target product (54% yield) was obtained with a melting point of 188°C (literature value 182-183°C [7]) and a thin-layer chromatographic Rf value of 0.79 (Expander D). Elemental analysis results: 41.74% C, 4.05% H, 29.35% N. Theoretically calculated values for the molecular formula C5H6ClN3: C 41.83%, H 4.21%, N 29.27%.

Purification Methods

Recrystallise it from EtOH. [Beilstein 24 H 84.]

References

[1] Russian Journal of General Chemistry, 2015, vol. 85, # 1, p. 79 - 87
[2] Zhurnal Obshchei Khimii, 2015, vol. 85, # 1, p. 79 - 87,9

2-Amino-4-chloro-6-methylpyrimidine synthesis

3977-29-5
5600-21-5
Synthesis of 2-Amino-4-chloro-6-methylpyrimidine from 2-Amino-6-methyl-4-pyrimidinol

2-Amino-4-chloro-6-methylpyrimidine Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Sodium Phosphorus oxitrichloride Guanidine hydrochloride Diethyl ether
4-Chloro-2-ethylsulfanyl-6-methyl-pyrimidine 2-Amino-6-methyl-4-pyrimidinol 2-Chloro-6-methylpyrimidin-4-ylamine 2,4-Dichloro-6-methylpyrimidine

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Preparation Products

SGI-1027 2-Amino-4,6-dimethylpyrimidine 2-amino-4-methyl-6-ethylaminopyrimidine 2-Amino-4-piperidino-6-methylpyrimidine N-(4-chloro-6-methyl-pyrimidin-2-yl)-acetamide

2-Amino-4-chloro-6-methylpyrimidine Suppliers

Global Suppliers ( 400)
Supplier Tel Email Country ProdList Advantage
Cheng Du Micxy Chemical Co.,Ltd 028-85632863 18108198598 3829395549@qq.com China 10469 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Supplier Advantage
Cheng Du Micxy Chemical Co.,Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60

View Latest Price from 2-Amino-4-chloro-6-methylpyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-6-methyl-2-pyrimidinamine pictures 2026-09-02 4-Chloro-6-methyl-2-pyrimidinamine
5600-21-5
 $1.00-200.00 1KG 99% Henan Fengda Chemical Co., Ltd
2-Amino-4-chloro-6-methylpyrimidine pictures 2026-08-20 2-Amino-4-chloro-6-methylpyrimidine
5600-21-5
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-amino-4-chloro-6-methylpyrimidine pictures 2022-04-22 2-amino-4-chloro-6-methylpyrimidine
5600-21-5
 98%min 100kgs/month Shanghai Rlavie Technology Co ltd

2-Amino-4-chloro-6-methylpyrimidine Spectrum

2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)MS2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)1HNMR2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)13CNMR2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)IR12-Amino-4-chloro-6-methylpyrimidine(5600-21-5)IR22-Amino-4-chloro-6-methylpyrimidine(5600-21-5)Raman

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TIMTEC-BB SBB004134 2-amino-4-chloro-6-methyl-pyrimidin 2-Pyrimidinamine, 4-chloro-6-methyl- 2-AMINO-4-CHLORO-6-METHYLPYRIMIDINE (ACLP) 2-Amino-4-chloro-6-methylpyrimidine ,97% 4-Chloro-6-methyl-pyrimidine-2-amine 2-Amino-4-chloro-6-methylpyrimidine,98% AMR human cell line ANTI-ADM (CENTER) antibody produced in rabbit Proadrenomedullin N-20 terminal peptide ProAM N-terminal 20 peptide ProAM-N20 2-AMINO-4-CHLORO-6-METHYLPYRIMIDINE 2-AMINO-4-CHLORO-6-METHYL-PYRIMIDINE*CRY STALLINE Amino-4-chloro-6-methylpyrimidine 2-Pyrimidinamine, 4-chloro-6-methyl- (9CI) 2-amino-4-chloro-methoxypyrimidine 4-chloro-6-methyl-2-pyrimidinamin 4-Chloro-6-methyl-2-pyrimidinamine 4-CHLORO-6-METHYL-PYRIMIDIN-2-YLAMINE 4-CHLORO-6-METHYL-2-PYRIMIDINYLAMINE AKOS MSC-0728 ACLP AM (inhibitor) AM (Nitrification inhibitor) AM (pesticide) am(nitrificationinhibitor) prepn. AM Pyrimidine, 2-amino-4-chloro-6-methyl- ASISCHEM C58325 4-Chloro-6-methyl-pyrimidinamine 2-Amino-4-chloro-6-methylpyrimidine > 2-Amino-4-chloro-6-methylpyrimidine ISO 9001：2015 REACH Cal-630&trade Fura-8FF&trade Rhod-4&trade Fura-10&trade 4-CHLORO-6-METHYLPYRIMIDIN-2-AMINE AM 5600-21-5 C5H6N3Cl HETERO CHLORIDE Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyrimidines PYRIMIDINE Heterocycle-Pyrimidine series Pyrazines, Pyrimidines & Pyridazines Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrimidinesHeterocyclic Building Blocks Amines Pyrazines, Pyrimidines & Pyridazines Pyrimidines FINE Chemical & INTERMEDIATES Fluorobenzene