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GNE-8505

GNE-8505 structure

CAS No.: 1620573-48-9

Chemical Name:: GNE-8505

Synonyms: GNE-8505;GNE8505,GNE 8505;5-(1-(cyclopropylmethyl)-5-(3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl)-1H-pyrazol-3-yl)-3-(trifluoromethyl)pyridin-2-amine;2-Pyridinamine, 5-[1-(cyclopropylmethyl)-5-[(1α,5α,6α)-3-(3-oxetanyl)-3-azabicyclo[3.1.0]hex-6-yl]-1H-pyrazol-3-yl]-3-(trifluoromethyl)-

CBNumber:: CB24676586

Molecular Formula:: C21H24F3N5O

Molecular Weight:: 419.44

MDL Number:: MFCD32062764

MOL File:: 1620573-48-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-28 20:33:29

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GNE-8505 Properties

Melting point	198.6-200 °C
Boiling point	552.3±50.0 °C(Predicted)
Density	1.69±0.1 g/cm3(Predicted)
pka	8.30±0.40(Predicted)
form	Solid
color	White to off-white

GNE-8505 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	44006	GNE-8505 ≥98%	1620573-48-9	1mg	$82	2026-04-30	Buy
Cayman Chemical	44006	GNE-8505 ≥98%	1620573-48-9	5mg	$326	2026-04-30	Buy
Cayman Chemical	44006	GNE-8505 ≥98%	1620573-48-9	10mg	$489	2026-04-30	Buy
ChemScene	CS-0083057	GNE-8505 99.53%	1620573-48-9	1mg	$108	2026-06-04	Buy
ChemScene	CS-0083057	GNE-8505 99.53%	1620573-48-9	5mg	$325	2026-06-04	Buy

Product number	Packaging	Price	Buy
44006	1mg	$82	Buy
44006	5mg	$326	Buy
44006	10mg	$489	Buy
CS-0083057	1mg	$108	Buy
CS-0083057	5mg	$325	Buy

GNE-8505 Chemical Properties,Uses,Production

Description

GNE-8505 is a DLK inhibitor (IC50 = 10nM).

Uses

GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK)[1].

References

[1] Le Pichon CE, et al. Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Sci Transl Med. 2017 Aug 16;9(403). pii: eaag0394. DOI:10.1126/scitranslmed.aag0394

GNE-8505 Preparation Products And Raw materials

Raw materials

Preparation Products

GNE-8505 Suppliers

Global( 15)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3493	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Jingmo (Xiamen) Biotechnology Co., Ltd	13621943973; 13621943973	sales@jamxmpharmatech.com	China	1190	58
cjbscvictory	13348960310 13348960310	3003867561@qq.com	China	10233	58
Wuhan Augda Biotechnology Co., Ltd	15071299552	262933239@qq.com	China	7200	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58
Xianning Shen Lan Biomedical Research and Development Co., Ltd.	18171815831	1341138380@qq.com	China	4572	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	5987	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11963	58

Supplier	Advantage
BOC Sciences	65
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
TargetMol Chemicals Inc.	58
Jingmo (Xiamen) Biotechnology Co., Ltd	58
cjbscvictory	58
Wuhan Augda Biotechnology Co., Ltd	58
TargetMol Chemicals Inc.	58
Xianning Shen Lan Biomedical Research and Development Co., Ltd.	58
Nantong QuanYi Biotechnology Co., Ltd	58
Shanghai Yifei Biotechnology Co. , Ltd.	58

View Lastest Price from GNE-8505 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	GNE-8505 1620573-48-9	$920.00-1790.00			10g	TargetMol Chemicals Inc.
	2025-07-23	GNE-8505 1620573-48-9	$920.00-1790.00			10g	TargetMol Chemicals Inc.

GNE-8505
1620573-48-9
$920.00-1790.00
TargetMol Chemicals Inc.

GNE-8505
1620573-48-9
$920.00-1790.00
TargetMol Chemicals Inc.

1620573-48-9(GNE-8505)Related Search:

GNE-8505 2-Pyridinamine, 5-[1-(cyclopropylmethyl)-5-[3-(3-oxetanyl)-3-azabicyclo[3.1.0]hex-6-yl]-1H-pyrazol-3-yl]-3-(trifluoromethyl)- GNE 7915 GNE-9605 GNE-495

GNE-490

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GNE-8505 5-(1-(cyclopropylmethyl)-5-(3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl)-1H-pyrazol-3-yl)-3-(trifluoromethyl)pyridin-2-amine GNE8505,GNE 8505 2-Pyridinamine, 5-[1-(cyclopropylmethyl)-5-[(1α,5α,6α)-3-(3-oxetanyl)-3-azabicyclo[3.1.0]hex-6-yl]-1H-pyrazol-3-yl]-3-(trifluoromethyl)- 1620573-48-9