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1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Structure
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine structure
CAS No.
4004-05-1
Chemical Name:
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
Synonyms
DOPE;1,2-Dioleoyl-sn-glycero-3-PE;(Z)-(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dioleate;18:1 PE;DOPE, 10 mM in DMSO;PE(18:1(9Z)/18:1(9Z));COATSOME ME-8181 (DOPE);18:1 (Δ9-Cis) PE (DOPE);L-β,γ-Dioleoyl-α-cephalin;18:1 (Delta9-Cis) PE (DOPE)
CBNumber:
CB2477530
Molecular Formula:
C41H78NO8P
Molecular Weight:
744.05
MDL Number:
MFCD16621009
MOL File:
4004-05-1.mol
MSDS File:
SDS
Last updated:2026-02-02 18:10:39
Product description Number Pack Size Price
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine ≥99.0% (10 mg phospholipid per ml CHCl3, TLC) 42490 2.5ml $90.1
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine ≥99.0% (10 mg phospholipid per ml CHCl3, TLC) 42490 10ml $336
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine >98.0%(T) D4251 250mg $241
1,2-Dioleoyl-sn-glycero-3-PE ≥98% 15091 100mg $81
1,2-Dioleoyl-sn-glycero-3-PE ≥98% 15091 250mg $120
More product size
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1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Properties

Melting point 200°C(lit.)
Boiling point 759.2±70.0 °C(Predicted)
Density 1.008±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: 31.25 mg/mL (42.00 mM)
pka 1.17±0.50(Predicted)
form lyophilized powder
color White to Light yellow
biological source synthetic
BRN 1718431
InChIKey MWRBNPKJOOWZPW-XFBMKQTANA-N
SMILES [C@H](COP(O)(=O)OCCN)(COC(=O)CCCCCCC/C=C\CCCCCCCC)OC(=O)CCCCCCC/C=C\CCCCCCCC |&1:0,r|
FDA UNII JNP6V6AI0U
UNSPSC Code 51191904
NACRES NA.85

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
Signal word  Danger
Hazard statements  H302-H315-H319-H331-H336-H351-H361d-H372-H412
Precautionary statements  P201-P273-P301+P312+P330-P302+P352-P304+P340+P311-P308+P313
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xn
Risk Statements  22-38-40-48/20/22-67-36/38-20-63
Safety Statements  36/37-26
RIDADR  UN 1888 6.1/PG 3
WGK Germany  3
F  8-10-23
HS Code  29232000
Storage Class 11 - Combustible Solids

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 42490 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine ≥99.0% (10 mg phospholipid per ml CHCl3, TLC) 4004-05-1 2.5ml $90.1 2025-07-31 Buy
Sigma-Aldrich 42490 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine ≥99.0% (10 mg phospholipid per ml CHCl3, TLC) 4004-05-1 10ml $336 2025-07-31 Buy
TCI Chemical D4251 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine >98.0%(T) 4004-05-1 250mg $241 2025-07-31 Buy
Cayman Chemical 15091 1,2-Dioleoyl-sn-glycero-3-PE ≥98% 4004-05-1 100mg $81 2024-03-01 Buy
Cayman Chemical 15091 1,2-Dioleoyl-sn-glycero-3-PE ≥98% 4004-05-1 250mg $120 2024-03-01 Buy
Product number Packaging Price Buy
42490 2.5ml $90.1 Buy
42490 10ml $336 Buy
D4251 250mg $241 Buy
15091 100mg $81 Buy
15091 250mg $120 Buy

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Chemical Properties,Uses,Production

Description

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a neutral phospholipid and displays sensitivity towards pH change and has been used in the preparation of liposome and giant unilamellar vesicles (GUVs).
Phosphatidylethanolamine (PE) is formed primarily in the reaction of CDP-ethanolamine and diacylglycerol. PE is one of the major components of cell membranes in bacteria and in nervous system.

Chemical Properties

Yellowish wax

Uses

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents.

Uses

1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.

Uses

18:1 (Δ9-Cis) PE (DOPE) has been used in the preparation of liposome for human uncoupling protein 1 (UCP1) reconstitution and for Caenorhabditis elegans autophagy related cysteine protease protein conjugation studies. It has also been used for the generation of giant unilamellar vesicles (GUVs) for septin induced deformation studies.

Definition

ChEBI: Dioleoyl phosphatidylethanolamine is a phosphatidylethanolamine in which the phosphatidyl acyl groups are both oleoyl.

General Description

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) is a neutral phospholipid and displays sensitivity towards pH change. At acidic it is an inverted hexagonal micelle and transforms to spherical micelle at alkaline pH.

Biological Activity

DOPE in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order. DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma and kidney cell lines (gene therapy).

Biochem/physiol Actions

DOPE in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order. DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma and kidney cell lines (gene therapy).

storage

Store at -20°C

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine synthesis

139115-88-1
4004-05-1
Synthesis of 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine from 9-Octadecenoic acid (9Z)-, (1S)-1-[[(3,4-dimethoxyphenyl)methoxy]ethyl]-1,2-ethanediyl ester (9CI)

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Preparation Products And Raw materials

Raw materials

9-Octadecenoic acid (9Z)-, (1S)-1-[[(3,4-dimethoxyphenyl)methoxy]ethyl]-1,2-ethanediyl ester (9CI)

Preparation Products

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Suppliers

Global( 215)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co.,Ltd. 		+86-0512-68071238 +86-13771819922 june@highfine.com China 489 58
XIAMEN SINOPEG BIOTECH CO., LTD.
+86-0592-7761068 +8617350879715 changaiwei@sinopeg.com China 1125 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16513 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32470 58
Supplier Advantage
Suzhou Highfine Biotech Co.,Ltd. 		58
XIAMEN SINOPEG BIOTECH CO., LTD.
58
BOC Sciences
58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Shandong chuangyingchemical Co., Ltd. 		58
Shochem(Shanghai) Co.,Ltd 		58
TargetMol Chemicals Inc. 		58

Related articles

View Lastest Price from 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DOPE pictures 2026-02-05 DOPE
4004-05-1
 US $0.00-0.00 / g 1g 98% 1g/bottle , 10g/bottle, 100g/bottle XIAMEN SINOPEG BIOTECH CO., LTD.
DOPE pictures 2026-02-02 DOPE
4004-05-1
 US $97.00 / mg 97.23% 10g TargetMol Chemicals Inc.
DOPE pictures 2025-10-13 DOPE
4004-05-1
 US $2.20-8.80 / kg 1kg 99%min 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
  • DOPE pictures
  • DOPE
    4004-05-1
  • US $0.00-0.00 / g
  • 98%
  • XIAMEN SINOPEG BIOTECH CO., LTD.
  • DOPE pictures
  • DOPE
    4004-05-1
  • US $97.00 / mg
  • 97.23%
  • TargetMol Chemicals Inc.
  • DOPE pictures
  • DOPE
    4004-05-1
  • US $2.20-8.80 / kg
  • 99%min
  • ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Spectrum

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine(4004-05-1)1HNMR

4004-05-1(1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine)Related Search:

1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE PHOSPHATIDYLETHANOLAMINE PHOSPHATIDYLETHANOLAMINE 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamino caproylmaleimide L-3-PHOSPHATIDYL[2-14C]ETHANOLAMINE,1,2-DIOLEOYL
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHATIDYLETHANOLAMINE 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamino (+)-biotin 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine DOPS 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-[3-(2-PYRIDYLDITHIO)PROPIONATE]
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, DANSYL-LABELED 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-(CARBOXYFLUORESCEIN) 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-(7-NITRO-2-1,3-BENZOXADIAZOL-4-YL) 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-(LISSAMINE RHODAMINE B SULFONYL) 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, PYRENE-LABELED
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-(DODECANYLAMINE) 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N,N-DIMETHYL 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-(BIOTINYL)

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3-SN-PHOSPHATIDYLETHANOLAMINE, 1,2-DIDEOYL 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE 1,2-DI([CIS]-9-OCTADECENOYL)-SN-GLYCERO-3-PHOSPHOETHANOLAMINE 18:1 PE L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL (C18:1,[CIS]-9) L-BETA,GAMMA-DIOLEOYL-ALPHA-CEPHALIN DIOLEOYL PHOSPHATIDYL ETHANOLAMINE DOPE 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 98+% L-A-phosphatidylethanolamine dioleoyl 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHO-ETHA-N OLAMINE, 10 MG/ML COATSOME ME-8181 (DOPE) 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, >99% 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, DOPE L-α-Phosphatidylethanolamine, dioleoyl 3-sn-Phosphatidylethanolamine, 1,2-dideoyl, L-β,γ-Dioleoyl-α-cephalin, DOPE (+)-1-O,2-O-Dioleoyl-L-glycerol 3-(phosphoric acid 2-aminoethyl) ester 1,2-Dioleoyl-3-sn-phosphatidylethanolamine O-(1-O,2-O-Dioleoyl-L-glycero-3-phospho)-2-aminoethanol Phosphoric acid hydrogen (2-aminoethyl)[(2R)-2,3-bis(oleoyloxy)propyl] ester Dioleoyl phosphoethanolamine (9Z)-9-Octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester 1,2-Di(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine L-β,γ-Dioleoyl-α-cephalin PE(18:1(9Z)/18:1(9Z)) 1,2-Dioleoyl-sn-glycero-3-PE L-A-PHOSPHATIDYLETHANOLAMINE, DIOLEO 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine≥ 98% (HPTLC) 2-Aminoethyl (R)-2,3-bis(oleoyloxy)propyl hydrogen phosphate 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) 9-Octadecenoic acid (9Z)-, 1,1'-[(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] ester 18:1 (Delta9-Cis) PE (DOPE) dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE) 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHATIDYLETHANOLAMINE (Z)-(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dioleate 9-Octadecenoic acid (9Z)-,(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediylester 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamin DOPE 1,2-dioloyl-sn-glycero-3-phosphoyl-ethanolamine DOPE, 10 mM in DMSO [(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate L-α-Phosphatidylethanolamine, dioleoyl 18:1 (Δ9-Cis) PE (DOPE) L-α-Phosphatidylethanolamine, dioleoyl Dioyl phosphatidylethanolamine DOPE NOPE,1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-diacyl-S-N-glycine-3-phosphorusacylethanolamine 4004-05-1 4004/5/1 BioChemical Biochemicals and Reagents Glycerophosphonoethanolamines Glycerides Cloning and Expression Lipids Molecular Biology Phosphoglycerides