DOPE NEW

DOPE

Modify Date: 2025-08-23 11:02:20

DOPE structure	Common Name	DOPE
	CAS Number	4004-05-1	Molecular Weight	744.034
	Density	1.008g/cm3	Boiling Point	759.2±70.0 °C at 760 mmHg
	Molecular Formula	C41H78NO8P	Melting Point	200 °C
	MSDS	ChineseUSA	Flash Point	413.0±35.7 °C
	Symbol	GHS06, GHS08	Signal Word	Danger

Purity		Quantity		Budget		Inquiry

Use of DOPE 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA[1].

• Properties

• Articles171

• Spectrum

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 Names

Name	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
Synonym	More Synonyms

 DOPE Biological Activity

Description	1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: helper lipid for liposome[1]
In Vitro	In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent)[1]. With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity[1]. LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells[1]. LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs[1].
References	[1]. Uemura Y, et al. The efficiency of lipid nanoparticles with an original cationic lipid as a siRNA delivery system for macrophages and dendritic cells.Pharm Dev Technol. 2019 Mar;24(3):263-268.

 Chemical & Physical Properties

Density	1.008g/cm3
Boiling Point	759.2±70.0 °C at 760 mmHg
Melting Point	200 °C
Molecular Formula	C41H78NO8P
Molecular Weight	744.034
Flash Point	413.0±35.7 °C
Exact Mass	743.546509
PSA	144.19000
LogP	14.79
Vapour Pressure	0.0±5.5 mmHg at 25°C
Index of Refraction	1.484

 MSDS

DOPE MSDS(Chinese)

 Safety Information

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H302-H315-H319-H331-H336-H351-H361d-H372
Precautionary Statements	P261-P281-P305 + P351 + P338-P311
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R22;R38;R40;R48/20/22
Safety Phrases	36/37
RIDADR	UN 1888
Hazard Class	6.1
HS Code	2931900090

Company Profile

     Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. 

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     Our research and development team possesses profound professional knowledge and extensive industry experience, dedicated to developing cutting-edge chemical materials to drive technological progress and industrial development. Our production facilities are equipped with state-of-the-art technology and a stringent quality control system to ensure product consistency and reliability.

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